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 A CME Symposium during the 2026 Heart Failure Management Conference in Fernandina Beach, Florida.
AGENDA
12:15 pm Introduction
Javed Butler, MD, MPH, MBA (Chair)
12:20 pm Aldosterone Pathophysiology, MRAs, and Outcomes in HFrEF
Javed Butler, MD, MPH, MBA
12:35 pm MRAs in HFmrEF and HFpEF: New Opportunities to Improve Patient Outcomes
Muthiah Vaduganathan, MD, MPH
12:50 pm Case Presentation: HFpEF—From Diagnosis to Optimal Patient Care
Presenter: Stephen Greene, MD
Panelists: Javed Butler, MD, MPH, MBA; Muthiah Vaduganathan, MD, MPH;
Orly Vardeny, PharmD, MS
1:05 pm Question-and-Answer
EDUCATIONAL OBJECTIVES
• Describe the mechanisms of action of mineralocorticoid receptor antagonists
(MRAs)
• Discuss the evidence for steroidal MRAs (sMRAs) in HFrEF and the challenges
associated with their use
• Explain similarities and differences between nonsteroidal MRAs (nsMRAs) and
sMRAs
• Interpret the clinical trial evidence for sMRAs and nsMRAs in patients with
HFmrEF and HFpEF
• Indicate best practices for the diagnosis and treatment of patients with HFpEF
Educational Grant
This activity is supported by an independent educational grant from Bayer.
CHAIR
Stephen Greene, MD
Associate Professor of Medicine
Duke University School of Medicine
Duke Clinical Research Institute
Durham, North Carolina
FACULTY
Muthiah Vaduganathan, MD, MPH
Co-Director, Center for Cardiometabolic Implementation Science
Assistant Professor of Medicine
Mass General Brigham and Harvard Medical School
Boston, Massachusetts
Orly Vardeny, PharmD, MS
Minneapolis VA Center for Care Delivery and Outcomes Research
Professor of Medicine
University of Minnesota
Minneapolis, Minnesota
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