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ClinicalTrials.gov: Other terms: heart disease | First posted in the last 14 days

Studies found on ClinicalTrials.gov by a search of: Other terms: heart disease | First posted in the last 14 days

A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and Obesity

November 05, 2026

Conditions: Hypertension; Obesity
Interventions: Drug: CagriSema; Drug: Semaglutide; Drug: Cagrilintide; Drug: Placebo
Sponsors: Novo Nordisk A/S
Not yet recruiting

Effect of Squatting Position in the Second Stage of Labor on Birth Outcomes

November 05, 2026

Conditions: Nulliparity; Labor Stage, Second; Birth Position; Squatting Position
Interventions: Other: Experimental (Squatting Position); Other: Routin Care (Lithotomy Position)
Sponsors: Ege University; Cigli Regional Training Hospital
Recruiting

Diastolic Shock Index for Predicting Hemodynamic Instability During Continuous Renal Replacement Therapy

November 05, 2026

Conditions: Acute Kidney Injury; Hypotension (MeSH: D007022); Critical Illness
Interventions: Other: Diastolic Shock Index Assessment
Sponsors: Istanbul University - Cerrahpasa
Not yet recruiting

Effects of Environmental Comfort and Oral Motor Stimulation on Comfort and Oral Feeding Readiness in Preterm Infants

November 05, 2026

Conditions: Prematurity; Feeding Behaviors
Interventions: Behavioral: Massage; Behavioral: White Noise; Behavioral: Oral Motor Stimulation; Other: Routine Care
Sponsors: Marmara University
Not yet recruiting

A Clinical Study Testing Enicepatide in Participants Living With Overweight or Obesity and Cardiovascular Disease

November 05, 2026

Conditions: Overweight; Obesity; Cardiovascular Disease
Interventions: Combination Product: Enicepatide; Combination Product: Placebo
Sponsors: Hoffmann-La Roche; Chugai Pharmaceutical
Not yet recruiting

Effects of Inhaled Nitric Oxide on Sublingual Microcirculation in Patients With Right Ventricular Dysfunction After Cardiac Surgery

November 05, 2026

Conditions: Cardiac Surgery Intensive Care Treatment; Pulmonary Hypertension; Right Ventricular (RV) Dysfunction
Interventions: Drug: Inhaled Nitric Oxide (iNO) use
Sponsors: Southeast University, China
Completed

Weighted Blankets for Agitation in Adults in the Intensive Care Unit

November 05, 2026

Conditions: Psychomotor Agitation; Critical Illness
Interventions: Other: Weighted-blanket; Other: Attention Control: Standard Blanket and Usual Comfort Measures
Sponsors: Anmed Health; American Association of Critical Care Nurses
Active, not recruiting

Hs-CRP-Guided Colchicine Treatment Targets in Very-High-Risk Patients With Coronary Artery Disease After PCI (TARGET-CHD)

November 05, 2026

Conditions: Coronary Artery Disease; Atherosclerotic Cardiovascular Disease (ASCVD); Residual Inflammatory Risk
Interventions: Drug: Colchicine (Colcrys®); Drug: Colchicine (Colcrys®)
Sponsors: Sir Run Run Shaw Hospital
Not yet recruiting

Sirolimus-Coated Versus Paclitaxel-Coated Balloon for Recurrent Coronary In-Stent Restenosis After Prior Paclitaxel-Coated Balloon Treatment (SPRIT)

November 05, 2026

Conditions: Coronary In-stent Restenosis; Coronary Artery Disease
Interventions: Device: SeQuent SCB sirolimus-coated balloon; Drug: RESTORE DEB paclitaxel-coated balloon
Sponsors: Sir Run Run Shaw Hospital
Not yet recruiting

Multi-center Study of Three-Dimensional Transesophageal Echocardiography in Patients With Secondary Mitral Regurgitation

November 05, 2026

Conditions: Mitral Valve Insufficiency
Interventions: Diagnostic Test: Transthoracic and Three-Dimensional Transesophageal Echocardiography
Sponsors: First Hospital of China Medical University; Sichuan Academy of Medical Sciences; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Not yet recruiting

Assessment of Transnational Performance of the Universal Cardiac Surgical Risk Score Across International Sites

November 05, 2026

Conditions: Heart Valve Diseases; Cardiac Surgical Procedures; Coronary Artery Disease
Interventions: Other: Risk score calculation
Sponsors: Union Health System
Not yet recruiting

Effects of C-Tactile-optimal Touch on Alcohol Craving and Relapse-Related Biomarkers in Alcohol Use Disorder

November 05, 2026

Conditions: Alcohol Use Disorder
Interventions: Device: CT- optimal Robotic skin stimulation; Device: Non-CT-optimal Robotic skin stimulation
Sponsors: Aalto University
Completed

Rowing-Based Exercise Intervention on Health and Quality of Life in Breast Cancer Survivors

November 05, 2026

Conditions: Breast Cancer; Breast Cancer Survivors
Interventions: Other: Behavioral Rowing-based exercise therapy program
Sponsors: Università Cattolica di Milano
Completed

Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E)

November 05, 2026

Conditions: Mild Cognitive Impairment; Memory Disorders; Dementia
Sponsors: Don Mottola Medical Center
Not yet recruiting

TRI-SUCCESS - Tricuspid Regurgitation Study of the Unica™ Cross-Caval System for the Evaluation of Efficacy and Safety in Significant TR Subjects

November 05, 2026

Conditions: Tricuspid Regurgitation; Tricuspid Regurgitation Functional
Interventions: Device: Innoventric Unica™ System
Sponsors: Innoventric LTD; Innoventric Inc.
Not yet recruiting

Effects of Individualized Preferred and Higher Treadmill Walking Speeds Followed by Cognitive Training on Heart Rate Variability, Gait Performance, and Motor-Cognitive Function in Older Adults With Type 2 Diabetes: A Randomized Controlled Trial With 4-Week Retention Follow-up

November 05, 2026

Conditions: Diabetes Mellitus, Type 2
Interventions: Behavioral: Individualized Higher-Speed Treadmill Walking; Behavioral: Individualized Preferred-Speed Treadmill Walking; Behavioral: Cognitive training; Behavioral: Fall-Prevention Health Education
Sponsors: University of Phayao
Active, not recruiting

A Phase-1 Trial to Investigate the Use of Pulsed Low-dose Rate Radiotherapy in Diffuse Midline Gliomas.

November 05, 2026

Conditions: Diffuse Midline Glioma
Interventions: Radiation: Pulsed Low-Dose-Rate Radiotherapy, pLDRT
Sponsors: Centro di Riferimento Oncologico - Aviano
Recruiting

Exercise in Alzheimer's Disease: Functional Biomarkers

November 05, 2026

Conditions: Alzheimer's Dementia (AD); Alzheimer Disease (AD)
Interventions: Other: High load; Other: Moderate load; Other: Healthy adults - High load; Other: Healthy adults - Moderate load
Sponsors: European University Miguel de Cervantes; Hospital Rio Hortega
Not yet recruiting

Busulfan-Based Versus TBI-Based Conditioning for Adult ALL-CR2 Allo-HSCT

November 05, 2026

Conditions: Acute Lymphoblastic Leukemia; Hematopoietic Stem Cell Transplantation
Interventions: Drug: Chemotherapy-based Conditioning Regimen; Radiation: TBI-based conditioning
Sponsors: Peking University People's Hospital
Not yet recruiting

Community Health Worker Nutrition Self-Management Support for Cardio-Kidney-Metabolic Health

November 05, 2026

Conditions: Hypertension (HTN); CKD - Chronic Kidney Disease; Cardio-Renal Syndrome; Food Insecurity; Type 2 Diabetes
Interventions: Behavioral: INTEGRATE-CHW; Behavioral: Usual Care
Sponsors: Florida International University; United States Department of Agriculture (USDA)
Not yet recruiting

Advancing Cardiovascular Health Among Adolescents With Intellectual Disabilities: Co-Development of Technology Interventions to Enhance Physical Activity

November 05, 2026

Conditions: Physical Activity; Intellectual Disabilities; Cardiovascular Health
Interventions: Behavioral: Virtual reality physical activity health promotion intervention
Sponsors: Michigan State University; National Institute of Nursing Research (NINR)
Not yet recruiting

Music Listening for Chronic Pain in Adults With Early-Stage Dementia

November 05, 2026

Conditions: Chronic Pain; Alzheimer Disease; Dementia
Interventions: Behavioral: MUSIC CARE® Standardized Music Listening; Behavioral: Neutral Spoken-Word Audiobook Control
Sponsors: Florida State University; National Institute on Aging (NIA); University of California, San Francisco
Not yet recruiting

Partial Cardiac Denervation for Preventing Atrial Fibrillation After CABG

November 05, 2026

Conditions: Postoperative Atrial Fibrillation; Coronary Artery Disease
Interventions: Procedure: Partial Cardiac Denervation
Sponsors: China National Center for Cardiovascular Diseases; Chinese Academy of Medical Sciences
Not yet recruiting

Remote Rehabilitation in Patients With HFpEF (PATRON-HF)

November 05, 2026

Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: Other: Telerehabilitation
Sponsors: American Heart of Poland; Andrzej Frycz Modrzewski Kraków University, Kraków, Poland; Scientia Research Institute
Recruiting

CAROTID DOPPLER AND CEREBRAL OXIMERY IN POST CARDIAC ARREST ICU PATIENTS

November 05, 2026

Conditions: Cardiac Arrest (CA); Carotid Doppler
Interventions: Diagnostic Test: Carotid Doppler Ultrasonography, Transcranial Doppler, Optic Nerve Sheath Diameter Measurement, and Cerebral Oximetry
Sponsors: Inonu University
Not yet recruiting

A Phase I Clinical Trial of CPU-YL01 Injection in Patients With Chronic Hepatitis B.

November 05, 2026

Conditions: Chronic Hepatitis B
Interventions: Drug: CPU-YL01 Injection Intramuscular administration; Drug: Placebo intramuscular injection
Sponsors: Jiangsu Chuangyuan Life Science and Technology Co., Ltd.
Enrolling by invitation

Exercise and Diet Supplements for Older Patients Undergoing TAVI: the IRON-TAVI Trial

November 05, 2026

Conditions: Aortic Stenosis Disease; Aortic Stenosis Symptomatic; Aortic Stenosis
Interventions: Behavioral: Personalized Multidomain Exercise Program; Dietary Supplement: Oral Protein and Iron Nutritional Supplementation; Other: Usual Care
Sponsors: University Hospital of Ferrara
Recruiting

dPmax for Predicting Right Ventricular Failure After Left Ventricular Assist Device Implantation

November 05, 2026

Conditions: Ventricular Dysfunction, Right
Interventions: Diagnostic Test: Arterial Pulse Contour Analysis
Sponsors: Pınar Kırdemir
Recruiting

Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care

November 05, 2026

Conditions: Sepsis; Circulatory Instability; Hemodynamic Monitoring
Sponsors: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Not yet recruiting

STAR0602 With Nivolumab in Non Small Cell Lung Cancer and in Metastatic Castrate-Resistant Prostate Cancer, and STAR0602 Alone in Thymic Carcinoma

November 05, 2026

Conditions: NSCLC; Non-Small Cell Lung Cancer; Lung Cancer; Prostate Cancer; Thymic Epithelial Tumors; TETs; Thymic Carcinomas; Thymomas; Metastatic Castrate-resistant Prostate Cancer; mCRPC
Interventions: Drug: STAR0602; Drug: Nivolumab
Sponsors: National Cancer Institute (NCI)
Not yet recruiting

Early Nutrition and Heart Structure and Function in Preterm Infants During the First Year of Life

November 05, 2026

Conditions: Cardiac Abnormalities; Nutrient Intake
Interventions: Diagnostic Test: echocardiography
Sponsors: Assiut University
Not yet recruiting

Reducing Exposure With Air Cleaners and Technology

November 05, 2026

Conditions: Asthma; COPD (Chronic Obstructive Pulmonary Disease)
Interventions: Device: Air Cleaner; Device: PM2.5 Monitor with Visual Air Quality Indicator; Behavioral: Educational Materials; Behavioral: Air Cleaner Technical Assistance
Sponsors: University of California, Berkeley; University of California, San Francisco; California Air Resources Board; Brightline Defense Project
Not yet recruiting

Effects of Different Physical Activity Strategies on Disease Activity of IBD Patients

November 04, 2026

Conditions: Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Interventions: Other: Pilates; Other: Combined Resistance and Aerobic Training
Sponsors: Szeged University
Not yet recruiting

Incremental Prognostic Utility of CBC-derived Inflammatory Indices After Incomplete Coronary Revascularization: Association With 12-months Cardiovascular Outcomes

November 04, 2026

Conditions: STEMI; High Risk NSTEMI
Sponsors: Assiut University
Not yet recruiting

A Study to Learn How Well People With Bronchiectasis Tolerate Continued Treatment With Verducatib After Earlier Studies (AIRTIVITY®-ON)

November 04, 2026

Conditions: Bronchiectasis
Interventions: Drug: verducatib
Sponsors: Boehringer Ingelheim
Not yet recruiting

Metabolic Profiling Among Patients Suspected of Infective Endocarditis - PPSIE Comparing Metabolomes of Bloodstream Infections Versus Infective Endocarditis

November 04, 2026

Conditions: Infective Endocarditis (IE)
Interventions: Procedure: Blood sample
Sponsors: University Hospital, Angers
Not yet recruiting

Compression-Only Versus Standard Basic Life Support Training in Nursing Students

November 04, 2026

Conditions: Cardiopulmonary Resuscitation; Out-of-Hospital Cardiac Arrest
Interventions: Behavioral: BLS and AED Training With Rescue Breaths; Behavioral: BLS and AED Training Without Rescue Breaths
Sponsors: Universitat Internacional de Catalunya
Not yet recruiting

A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control

November 04, 2026

Conditions: Hypertension
Interventions: Behavioral: Core intervention (Fitbit tracking and BP health education); Behavioral: Aerobic training (AT); Behavioral: Dynamic resistance training (DRT); Behavioral: Isometric resistance training (IRT)
Sponsors: Northwestern University
Not yet recruiting

Effect of a Web-based Application With Integrated AI Chat for Cardiovascular Risk Support

November 04, 2026

Conditions: AI Chatbot; Cardiovascular (CV) Risk
Interventions: Other: web application with AI chat; Other: usual clinic care follows the national prevention and management guidelines for major cardiovascular risk factors
Sponsors: Cairo University
Not yet recruiting

Internal Mammary Node Irradiation After Neoadjuvant Systemic Therapy for Breast Cancer

November 04, 2026

Conditions: Breast Neoplasms
Interventions: Radiation: Locoregional Radiotherapy With Internal Mammary Node Irradiation; Radiation: Locoregional Radiotherapy Without Internal Mammary Node Irradiation
Sponsors: Mahidol University
Not yet recruiting

The Effect of Levosimendan on Pulmonary Artery Pressure and Right Ventricular Function in the Perioperative Period in Patients With CTEPH After Pulmonary Thromboendarterectomy

November 04, 2026

Conditions: LEVOSIMENDAN; PULMONARY THROMBOENDARTERECTOMY; Chronic Thromboembolic Pulmonary Hypertension (CTEPH); Pulmonary Hypertension
Interventions: Drug: Infusion of levosimendan; Drug: Placebo infusion "Soluvit"
Sponsors: Meshalkin Research Institute of Pathology of Circulation
Recruiting

Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural Analgesia

November 04, 2026

Conditions: Procedural Pain; Procedural Sedation and Analgesia; Intracranial Pressure
Interventions: Drug: ketamine
Sponsors: Ankara Etlik City Hospital
Recruiting

Effect of the 4-7-8 Breathing Technique Before Central Venous Catheter Insertion

November 04, 2026

Conditions: Anxiety; Pain; Vital Sign Evaluation; 4-7-8 Breathing Technique
Interventions: Behavioral: 4-7-8 breathing technique
Sponsors: Mersin University
Completed

Comparing Two Laparoscopic Techniques for Hernia Repair in Children

November 04, 2026

Conditions: Inguinal Hernia
Interventions: Procedure: Laparoscopic Percutaneous Extraperitoneal Closure (LPEC); Procedure: Laparoscopic Intracorporeal Suture (LIS)
Sponsors: Quaid-e-Azam Medical College
Recruiting

3D Versus 2D Strain Echocardiography for Early Detection of Cardiotoxicity During Cancer Therapy

November 04, 2026

Conditions: Cancer Related Cardiovascular Toxicity; Anthracycline Related Cardiotoxicity in Breast Cancer; Breast Cancer; Cardiotoxicity; Echocardiography, Three-Dimensional
Sponsors: Region Skane
Recruiting

Computational μFR-Guided Versus Angiographic Guidance in Drug-Coated Balloon Angioplasty

November 04, 2026

Conditions: Coronary Artery Disease
Interventions: Procedure: μFR-Based Group (Intervention)
Sponsors: Centro Cardiologico Monzino; Azienda Ospedaliera Universitaria Integrata Verona
Recruiting

PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite)

November 04, 2026

Conditions: Carotid Atherosclerosis; Carotid Artery Stenosis Asymptomatic; Asymptomatic Carotid Artery Stenosis
Interventions: Drug: 64Cu-NODAGA-CANF
Sponsors: Washington University School of Medicine; National Heart, Lung, and Blood Institute (NHLBI); Cedars-Sinai Medical Center
Not yet recruiting

Coronary Myocardial Bridge and Coronary Plaques on MDCT

November 04, 2026

Conditions: Myocardial Bridging; Coronary Atherosclerosis
Sponsors: Sohag University
Recruiting

Rehabilitation Program for People With Methamphetamine-Associated Cardiopulmonary Conditions

November 04, 2026

Conditions: Methamphetamine-Associated Heart Failure; Methamphetamine-Associated Pulmonary Arterial Hypertension
Interventions: Behavioral: Increasing control over stimulant use and physical health through incentivized rehabilitation; Other: Usual Care
Sponsors: Michael Incze; National Institute on Drug Abuse (NIDA); University of Utah
Recruiting

Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU

November 04, 2026

Conditions: Traumatic Brain Injury (TBI) Patients; Intracerebral Hemorrhage; Subarachnoid Hemorrhage; Cardiac Arrest (CA)
Sponsors: Columbia University; Neurocritical Care Foundation
Recruiting

EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular Disease

November 04, 2026

Conditions: Atherosclerotic Cardiovascular Disease
Interventions: Other: EHR Nudge
Sponsors: NYU Langone Health; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Single-center Transformational Study on Feasibility and Efficacy of Respiratory Motion Management Using Novel Position Fixation Device for Lung Cancer Patients Undergoing Stereotactic Body Radiation Therapy(2023 No.358 Project)

November 04, 2026

Conditions: Non-Small Cell Carcinoma of Lung
Interventions: Device: Novel Respiratory Immobilization Device for Lung SBRT
Sponsors: Tianjin Medical University Cancer Institute and Hospital
Enrolling by invitation

King's Theory-Based Multicomponent Interventions in Heart Failure Patient Rehabilitation

November 04, 2026

Conditions: Heart Failure; Cardiac Rehabilitation
Interventions: Behavioral: King's Theory of Goal Attainment; Other: Standard Care (in control arm)
Sponsors: Saglik Bilimleri Universitesi
Not yet recruiting

Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly Patients

November 04, 2026

Conditions: Airway Complication of Anesthesia; Hemodynamic Instability; Postoperative Complications; Emergence Delirium, Anesthesia
Interventions: Drug: Dexmedetomidine; Drug: Alkalinized Lidocaine
Sponsors: Beni-Suef University
Not yet recruiting

High-Tech, High-Touch

November 04, 2026

Conditions: Stress (Psychology); Resilience, Psychological; Anxiety; Depressive Symptoms; Well-being; Sleep Quality
Interventions: Device: Wearable ring with continuous biometric monitoring; Behavioral: AI health coaching application; Other: Osteopathic manipulative treatment (OMT)
Sponsors: Touro University, California; American Osteopathic Foundation
Completed

Multimodal MRI Assessment of Brain Fluid Circulation in Idiopathic Intracranial Hypertension

November 04, 2026

Conditions: Idiopathic Intracranial Hypertension
Sponsors: Beijing Tiantan Hospital
Not yet recruiting

Early Feasibility Study of the Capstan Medical TMVR System

November 04, 2026

Conditions: Mitral Regurgitation (MR)
Interventions: Device: Capstan Compass Robotic System for Transcatheter Mitral Valve Replacement
Sponsors: Capstan Medical
Not yet recruiting

Emotional and Affective Responses to Music Inspired by Permafrost Thaw in Nunavik

November 04, 2026

Conditions: Emotional, Affective, and Physiological Responses to Audiovisual Artworks Inspired by Climate-Related Environmental Changes in Nunavik
Interventions: Other: Viewing Four Audiovisual Artworks Inspired by Environmental Changes in Nunavik
Sponsors: Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Not yet recruiting

A Study of GKL-006Allo Injection in Patients With Ankylosing Spondylitis

November 04, 2026

Conditions: Ankylosing Spondylitis
Interventions: Biological: GKL-006Allo
Sponsors: Beijing Gene Key Life Technology Co., Ltd
Not yet recruiting

Sacubitril/Valsartan vs Standard Treatment for Preventing Atrial Fibrillation Recurrence After Catheter Ablation in Persistent Atrial Fibrillation Patients With Without Hypertension

November 04, 2026

Conditions: Atrial Fibrillation (Persistent); Catheter Ablation; Non-hypertension; Angiotensin Receptor/Neprilysin Inhibitor
Interventions: Drug: Sacubitril/Valsartan; Other: Standard Care
Sponsors: Ruijin Hospital
Not yet recruiting

SND002 Cell Injection in Participants With Advanced Malignant Solid Tumors

November 04, 2026

Conditions: Colorectal Neoplasms; Stomach Neoplasms; Solid Tumor Malignancies
Interventions: Biological: SND002 Cell Injection
Sponsors: Guizhou Sinorda Pharmaceutical Co., Ltd.
Not yet recruiting

Migraine Menopause Study

November 04, 2026

Conditions: Migraine; Menopausal; Perimenopause
Interventions: Drug: Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution; Drug: Placebo Normal Saline (NS); Drug: Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution
Sponsors: Alberta Neurologic Centre; H. Lundbeck A/S
Not yet recruiting

Integrating Wearable Monitoring and Clinical Data for Stroke Early Warning

November 04, 2026

Conditions: Stroke; Ischemic Stroke; Recurrent Stroke; Transient Ischemic Attack; Intracerebral Haemorrhage; Subarachnoid Hemorrhage
Interventions: Device: Huawei HAY20; Behavioral: AI agent dialogue
Sponsors: Affiliated Hospital of Nantong University; Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Not yet recruiting

Curcumin Nano Patch and Autonomic Function in Shift-Working Healthcare Professionals

November 04, 2026

Conditions: Occupational Stress; Sleep Quality
Interventions: Other: Curcumin Nano Patch; Other: Cooling Control Patch (Placebo)
Sponsors: Taipei Medical University Shuang Ho Hospital
Completed

Real-World Validation of A Huawei Smartwatch for Hypertension Risk Screening in Malaysia

November 03, 2026

Conditions: Hypertension; Vascular Disease Risk; Cardiovascular (CV) Risk; Masked Hypertension; White Coat Hypertension
Sponsors: Sunway University; Huawei Device Co., Ltd
Enrolling by invitation

Video- and Game-Based Interventions During Pediatric Peripheral Venous Catheterization

November 03, 2026

Conditions: Peripheral Venous Catheterization
Interventions: Other: Researcher-Developed Educational Video; Other: Developed Educational Card Game
Sponsors: Selcuk University
Completed

Out-Patient Proactive Observation With Wearable-Assisted Tracking for Cardiovascular Health Management

November 03, 2026

Conditions: Chronic Coronary Syndrome
Interventions: Device: Wearable Device-Based Monitoring and LE8 Feedback; Other: Routine Outpatient Care With Data-Blinded Wearable Monitoring
Sponsors: China National Center for Cardiovascular Diseases; Guangdong HeyTap Technology Co., Ltd.
Not yet recruiting

Propofol Target-Controlled Infusion Versus Dexmedetomidine for Sedation During Chronic Subdural Hematoma Surgery Under Local Anesthesia

November 03, 2026

Conditions: Chronic Subdural Hematoma
Interventions: Drug: Dexmedetomidine; Drug: Propofol (Astra-Zeneca)
Sponsors: National Institute of Neurology, Tunisia
Not yet recruiting

Effect of Anifrolumab on Arterial Inflammation in Systemic Lupus Erythematosus Study

November 03, 2026

Conditions: Systemic Lupus Erythematosus; Atherosclerosis Generalized
Interventions: Diagnostic Test: 68-Gallium Dotatate; Drug: Anifrolumab
Sponsors: University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; AstraZeneca
Recruiting

Effect of Nurse-Directed Therapeutic Positioning in Children With Pneumonia

November 03, 2026

Conditions: Pediatric Pneumonia
Interventions: Behavioral: Nurse - Directed Side - Lying Positioning; Behavioral: Nurse - Directed Semi-fowler's positioning
Sponsors: University of Baghdad
Not yet recruiting

Outpatient Pramlintide Study

November 03, 2026

Conditions: Type 1 Diabetes
Interventions: Device: MPC closed-loop system in insulin only mode; Device: MPC closed-loop system in Insulin/Pramlintide mode
Sponsors: Oregon Health and Science University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

Inspiratory Muscle Training in Axial Spondyloarthritis

November 03, 2026

Conditions: Axial Spondyloarthritis (AxSpA)
Interventions: Behavioral: Aerobic Exercise; Behavioral: Conventional Spinal Mobility Exercises; Behavioral: Inspiratory Muscle Training
Sponsors: Bursa Yuksek Ihtisas Training and Research Hospital
Completed

Heart and Brain Blood Flow in Obstructive Sleep Apnea

November 03, 2026

Conditions: Obstructive Sleep Apnea (OSA)
Sponsors: Copenhagen University Hospital, Rigshospitalet
Not yet recruiting

Roxadustat and Myocardial Injury After Off-Pump Coronary Artery Bypass Surgery

November 03, 2026

Conditions: Coronary Artery Disease; Coronary Artery Bypass Grafting; Hypoxia-Inducible Factor 1, Alpha Subunit; Prolyl-Hydroxylase Inhibitors; Myocardial Ischemia; Myocardial Infarction Postoperative
Interventions: Drug: Roxadustat; Drug: Placebo
Sponsors: Peking University First Hospital
Not yet recruiting

ADVA ACE Coronary Stent System in Coronary Artery Disease Patients (ADVANCE)

November 03, 2026

Conditions: Coronary Artery Disease; De Novo Stenosis Lesion; Coronary Stent Implantation
Interventions: Device: ADVA ACE Everolimus Eluting Coronary Stent System
Sponsors: Advanced MedTech Solutions Pvt. Ltd.; Clicebo Solutions Private Limited
Not yet recruiting

Multicomponent Exercise Program in Women With Hypertension

November 03, 2026

Conditions: Hypertension; Cardiovascular Risk
Interventions: Behavioral: Multicomponent exercise program
Sponsors: Universidad Pedagogica Nacional, Colombia
Completed

Evaluating a Digital Aid to Improve ICD Decisions

November 03, 2026

Conditions: Shared Decision-making
Interventions: Device: Arm A: Online, patient-facing decision-making aid (app) with personalized risk information.; Device: Arm B - Online, patient-facing decision-making app without personalized risk information.; Other: Arm C - Usual Care/No Device
Sponsors: Stanford University; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Inspiratory Muscle Training and Diaphragmatic Breathing in GAD

November 03, 2026

Conditions: Generalized Anxiety Disorder (GAD)
Interventions: Device: Inspiratory Muscle Training; Behavioral: Diaphragmatic Breathing Exercises; Behavioral: Progressive Muscle Relaxation
Sponsors: Saglik Bilimleri Universitesi
Recruiting

Effect of Double-Tap Optimization on Valve Expansion and Hemodynamics in Balloon-expandable Transcatheter Aortic Valve Implantation: A Randomized Clinical Trial (DO-OPT TAVI Trial)

November 03, 2026

Conditions: Severe Aortic Stenosis
Interventions: Procedure: Double-Tap Balloon Post-dilatation; Procedure: Conventional Single-Inflation TAVI
Sponsors: Yonsei University
Not yet recruiting

31P-MRS Myocardial Energetic Phenotyping and Prognosis Across the Cardiac Disease Spectrum

November 03, 2026

Conditions: Cardiomyopathies; Heart Failure
Sponsors: Chinese Academy of Medical Sciences, Fuwai Hospital
Recruiting

Development, Validation, and Clinical Trial of a Prediction Tool for High-Risk Emergency Department Revisits

November 03, 2026

Conditions: Emergency Department; Revisit
Interventions: Other: ED-HIKRS; Other: Usual Care
Sponsors: National Taiwan University Hospital
Not yet recruiting

Heart@Home Safety and Efficacy of Hospital-at-Home Care Versus Standard Hospitalization in Cardiac Patients

November 03, 2026

Conditions: Myocardial Infarction; Myocarditis Acute; Pericarditis; Pulmonary Embolism Acute; Heart Failure Acute; Transcatheter Valve Replacement; Defibrillators, Implantable
Interventions: Other: Remote cardiovascular monitoring at home
Sponsors: Tel-Aviv Sourasky Medical Center; SABAR HEALTH; SHL Telemedicine Ltd.
Recruiting

Alberta Cancer Exercise Dose in Colorectal Cancer

November 03, 2026

Conditions: Cancer; Colorectal Cancer
Interventions: Behavioral: Group Exercise Classes - Arm 1; Behavioral: Group Exercise Classes - Arm 2
Sponsors: University of Calgary; Arthur J.E. Child Comprehensive Cancer Centre
Not yet recruiting

Retrospective Analysis of Erectile Dysfunction (ED) Patients Based on a Large-scale Clinical Database

November 03, 2026

Conditions: Erectile Dysfunction
Sponsors: Second Affiliated Hospital, Zhejiang University, School of Medicine
Completed

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk

November 03, 2026

Conditions: Obesity; Overweight; Cardiovascular Diseases; Diabetes Mellitus, Type 2
Interventions: Drug: Eloralintide; Drug: Placebo
Sponsors: Eli Lilly and Company
Not yet recruiting

A Study of MC001 in Patients With Advanced or Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) and Other Folate Receptor Alpha (FRα)-Expressing Solid Tumors

November 03, 2026

Conditions: Pancreatic Ductal Adenocarcinoma (PDAC); Advanced Solid Tumor Cancer; Metastatic Pancreatic Cancer; Metastatic Solid Tumors
Interventions: Biological: MC001
Sponsors: Medicovestor, Inc
Not yet recruiting

A Prospective Comparative Clinical Trial of Postoperative Delirium Incidence in Open Versus Laparoscopic Nephrectomy

November 03, 2026

Conditions: Postoperative Delirium (POD) After Nephrectomy
Interventions: Procedure: Open Nephrectomy; Procedure: Laparoscopic Nephrectomy
Sponsors: Alexandria University
Completed

A Study of Opsynvi in Adults Participants With Pulmonary Arterial Hypertension in Korea

November 03, 2026

Conditions: Pulmonary Arterial Hypertension
Sponsors: Janssen Korea, Ltd., Korea
Not yet recruiting

The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced Cardiotoxicity

November 03, 2026

Conditions: Doxorubicin Induced Cardiotoxicity; Doxorubicin Induced Cardiomyopathy; Doxorubicin; Doxorubicin Adverse Reaction
Interventions: Drug: Nicorandil Oral Tablet; Drug: Adriamycin (Doxorubicin)
Sponsors: Universiti Sains Malaysia
Not yet recruiting

Comparison of Lidocaine With and Without Adrenaline for Reducing Ecchymosis

November 03, 2026

Conditions: Ecchymosis; Adverse Anesthesia Outcome; Complications Associated With Device; Bleeding
Interventions: Drug: 1% Lidocaine with adrenaline; Drug: 1% Lidocaine
Sponsors: Chulalongkorn University; King Chulalongkorn Memorial Hospital
Completed

Paroxysmal Atrial Fibrillation Repeat Ablation Strategies With Durably Isolated Pulmonary Veins

November 03, 2026

Conditions: Ablation Techniques; Atrial Fibrillation (Paroxysmal); Quality of Life
Interventions: Procedure: Tailored Strategy; Procedure: Control Strategy
Sponsors: Ottawa Heart Institute Research Corporation
Not yet recruiting

Effects of Concurrent Training on Serum PCSK9 Levels in Adults With Overweight

November 03, 2026

Conditions: Overweight; Lipid Metabolism; Cholesterol Metabolism
Interventions: Behavioral: Concurrent Aerobic and Resistance Training
Sponsors: Kastamonu University
Recruiting

The Effect of a Multimodal Preventive Intervention in Patients With Asymptomatic Peripheral Artery Disease

November 03, 2026

Conditions: Peripheral Arterial Disease; Asymptomatic Diseases; Ankle Brachial Index (0.9 or Less)
Interventions: Other: Multimodal intervention
Sponsors: Värmland County Council, Sweden
Completed

Ticagrelor for Inflammation and Cardiovascular Risk in Patients With Chronic Kidney Disease

November 02, 2026

Conditions: Chronic Kidney Disease (CKD)
Interventions: Drug: Ticagrelor: an oral, direct-acting, reversibly binding P2Y12 receptor antagonist; Drug: Placebo
Sponsors: University of Arkansas; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Multimodality Location Prediction Accuracy of Leadless Pacemaker Positioning

November 02, 2026

Conditions: Sinus Pause; Sinus Sick Syndrome; Heart Block; Arrhythmias, Cardiac
Interventions: Diagnostic Test: Cardiac Imaging by TTE or CTA
Sponsors: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Recruiting

SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome

November 02, 2026

Conditions: Cardiovascular-kidney-metabolic Syndrome; Diabete Type 2; Chronic Kidney Disease; Heart Failure
Interventions: Behavioral: Real-Time EHR Prompts and Audit-and-Feedback Reports
Sponsors: Kaiser Permanente
Not yet recruiting

Accelerated Theta-Burst Stimulation for Refractory Central Post-Stroke Pain

November 02, 2026

Conditions: Central Post-Stroke Pain; Stroke; Ischemic Stroke and Hemorrhagic Stroke
Interventions: Device: High-dose accelerated intermittent theta burst stimulation (aiTBS); Device: Low-dose accelerated intermittent theta burst stimulation (aiTBS)
Sponsors: Duke University; American Heart Association
Not yet recruiting

Virtual Reality for Anxiety and Birth Satisfaction During Elective Cesarean Section

November 02, 2026

Conditions: Anxiety; Cesarean Section; Birth Satisfaction
Interventions: Device: Virtual Reality Distraction
Sponsors: Tarsus University
Not yet recruiting

Risk-Adapted Segmental Esophagus-Sparing Radiotherapy for Definitive Non-Small Cell Lung Cancer

November 02, 2026

Conditions: Non-Small Cell Lung Cancer
Interventions: Radiation: Risk-Adapted Segmental Esophagus-Sparing IMRT/VMAT; Radiation: Standard IMRT/VMAT Without Active Esophageal Avoidance
Sponsors: Ruijin Hospital; Baotou Cancer Hospital; The First Affiliated Hospital of Qiqihar Medical University; Linfen No.4 People's Hospital; Qinghai People's Hospital; Qiandongnan Miao and Dong Autonomous Prefecture People's Hospital; Qianxinan Prefecture People's Hospital, Guizhou
Not yet recruiting

Notification Of High-Risk Veterans for Access to Heart Failure Prevention

November 02, 2026

Conditions: Heart Failure
Interventions: Other: Notification and Cardiology Referral; Other: Notification and Cardiology Referral Plus Care Navigation
Sponsors: Palo Alto Veterans Institute for Research; American Heart Association
Not yet recruiting

Impact Of Aerobic Exercise on Sleep Quality and Postural Control Interplay Among University Students

November 02, 2026

Conditions: Healthy Individuals
Interventions: Behavioral: Aerobic exercise Training; Behavioral: Sleep hygiene education
Sponsors: Cairo University; October University for Modern Sciences and Arts
Not yet recruiting

Structured Treatment and Resource Efficiency Assessment With Lean Six Sigma Integration for Pulmonary Vein Isolation

November 02, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Procedure: Pulsed Field Ablation (PFA); Procedure: Cryoballoon Ablation (Cryo)
Sponsors: St. Josefs-Hospital Wiesbaden GmbH
Recruiting

Target Value Study to Evaluate the Safety and Efficacy of the Taurus NXT® Transcatheter Aortic Valve System for the Treatment of Severe Calcific Aortic Stenosis

November 02, 2026

Conditions: Aortic Stenosis
Interventions: Device: TAVR
Sponsors: Peijia Medical Technology (Suzhou) Co., Ltd.
Active, not recruiting

Threshold-Based Versus Range-Based Exercise Intensity Prescription in Cardiac Rehabilitation

November 02, 2026

Conditions: Cardiovascular Diseases; Cardiac Rehabilitation
Interventions: Other: Threshold-Based Aerobic Exercise Intensity Prescription; Other: Range-Based Aerobic Exercise Intensity Prescription
Sponsors: Hasselt University; University Hospital, Antwerp
Not yet recruiting

Resumption of Anticoagulation After Major Gastrointestinal Bleeding in Patients With Atrial Fibrillation

November 02, 2026

Conditions: Atrial Fibrillation (AF); Major Gastrointestinal Bleeding (MGIB)
Sponsors: Società Italiana di Medicina Interna
Active, not recruiting

Effects of Transcranial Direct Current Stimulation on Cyberaggressive Behaviour in Adults

November 02, 2026

Conditions: Cyberaggression
Interventions: Device: Anodal transcranial direct current stimulation; Device: Cathodal transcranial direct current stimulation; Device: Sham transcranial direct current stimulation
Sponsors: Nanyang Technological University
Not yet recruiting

Cardiovascular Disease Multimorbidity

November 02, 2026

Conditions: Cardiovascular Diseases
Interventions: Behavioral: HEARTS; Behavioral: PF
Sponsors: NYU Langone Health; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 Diabetes

November 02, 2026

Conditions: Diabete Mellitus; Autoimmune Diabetes; Latent Autoimmune Diabetes in Adult (LADA); Type 2 Diabetes; Heart Disease; Cardiometabolic Diseases; Cardiomyopathy, Diabetic
Interventions: Diagnostic Test: Cardiac Magnetic Resonance
Sponsors: University of Roma La Sapienza
Recruiting

Impact of a Tailored Digital Intervention on Sedentary Behaviour and Physical Health in Long-term Cardiac Rehabilitation Patients

November 02, 2026

Conditions: Cardiovascular Diseases (CVD); Coronary Disease; Heart Failure; Cardiac Rehabilitation; Sedentary Behaviour
Interventions: Behavioral: Standard Cardiac Rehabilitation Care; Behavioral: Tailored behavioural counselling; Behavioral: Digital prompts
Sponsors: University of Lisbon
Recruiting

Society of Thoracic Surgeons and American College of Cardiology Transcatheter Valve Therapy Registry (STS/ACC TVT Registry™): Registry Purpose and Research Objective

November 02, 2026

Conditions: Aortic Valve Stenosis
Interventions: Procedure: Transcatheter Aortic Valve Replacement
Sponsors: American College of Cardiology; The Society of Thoracic Surgeons
Recruiting

Sarcopenia and Training Outcomes in Post-cardiac Surgery Patients

November 02, 2026

Conditions: Sarcopenia; Cardiac Surgery
Interventions: Other: No intervention (observational study)
Sponsors: Universitaire Ziekenhuizen KU Leuven
Recruiting

LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI

November 02, 2026

Conditions: TAVI(Transcatheter Aortic Valve Implantation); Left Bundle Branch Block; Reduced Left Ventricular Ejection Fraction
Interventions: Procedure: Left bundle branch area pacing with pacemaker; Procedure: Implantation loop recorder
Sponsors: University Hospital, Clermont-Ferrand
Not yet recruiting

Team-Based Shared Decision-Making Program in Hypertension Control (Healthy Heart - BP Program)

November 02, 2026

Conditions: Hypertension (HTN); Blood Pressure
Interventions: Behavioral: Pharmacist-led Team-Based SDM on health behavior change and medication management for HTN control; Behavioral: Nurse-led Team-Based SDM on health behavior change and medication management for HTN control; Behavioral: Telehealth SDM visits focus on medication management and health behavior change; Behavioral: Self-monitored health behaviors and medications via Healthy Heart; Behavioral: Self-measured blood pressure (SMBP); Behavioral: Care partners (family/caregivers) support
Sponsors: Johns Hopkins University
Not yet recruiting

Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Sphenopalatine Ganglion Block for Functional Endoscopic Sinus Surgery

November 02, 2026

Conditions: Post Operative Pain; Emergence Agitation; Functional Endoscopic Sinus Surgery
Interventions: Drug: Bupivacaine & normal saline; Drug: Dexmedetomidine & Bupivacaine.; Drug: Dexamethasone & Bupivacaine.
Sponsors: Sohag University
Not yet recruiting

Anterior Nerves of the Knee Block Versus Femoral Nerve Block for Knee Arthroscopy

November 02, 2026

Conditions: Postoperative Pain; Knee Arthroscopy; Analgesia
Interventions: Procedure: Anterior Nerves of the Knee (ANK) Block; Procedure: Femoral Nerve Block
Sponsors: Van Training and Research Hospital
Recruiting

Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge

November 02, 2026

Conditions: Fluid Responsiveness; Laparoscopic Surgery; Hemodynamic Monitoring
Sponsors: University Of Perugia
Not yet recruiting

Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac Arrest

November 02, 2026

Conditions: Out-of-hospital Cardiac Arrest (OHCA)
Interventions: Procedure: Transesophageal Echocardiography-Guided Chest Compression; Procedure: Conventional Cardiopulmonary Resuscitation
Sponsors: Far Eastern Memorial Hospital; National Science and Technology Council, Taiwan
Not yet recruiting

Pre-Examination Reflexology for Anxiety and Pain During Pelvic Examination

November 02, 2026

Conditions: Anxiety
Interventions: Behavioral: Pre-Examination Reflexology
Sponsors: Goni Sintov
Not yet recruiting

TRINITY TRIAL; Trial Of PRRT Plus CAPTEM Vs CAPTEM Alone In Well Differentiated GEP NETS

November 02, 2026

Conditions: Gastroenteropancreatic Neuroendocrine Tumors
Interventions: Drug: Capecitabine; Drug: Temozolomide (TMZ); Drug: Lutetium Lu 177 Dotatate
Sponsors: Tata Memorial Hospital; Tata Memorial Centre
Not yet recruiting

Pulse Wave vs. Saline Contrast EIT for Pulmonary Perfusion in ARDS

November 02, 2026

Conditions: ARDS (Acute Respiratory Distress Syndrome); Electrical Impedance Tomography (EIT); Mechanical Ventilation
Sponsors: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Recruiting

Effects of Taurine Supplementation and Morning or Evening High-intensity Exercise on Circadian Clock Genes and Inflammatory Parameters in Adult Women With Obesity

November 02, 2026

Conditions: Obesity (Disorder); Inflammation
Interventions: Dietary Supplement: Taurine supplementation; Drug: Placebo Supplementation; Behavioral: High-intensity interval training (HIIT)
Sponsors: University of Sao Paulo
Not yet recruiting

Early Heart Rate Variability and Sleep and Quality of Recovery After Cesarean Delivery

November 02, 2026

Conditions: Recovery of Function; Postoperative Period; Cesarean Section
Interventions: Device: Wearable-derived heart rate variability and sleep monitoring
Sponsors: Buca Seyfi Demirsoy State Hospital
Not yet recruiting

Oura Ring OA15 Validation

November 02, 2026

Conditions: Healthy Adult; Sleep Apnea
Sponsors: Ouraring Inc.; Clayton Sleep Institute, LLC
Recruiting

Relationship Between Insulin Dose and Complications in Type 1 Diabetes

November 02, 2026

Conditions: Diabetes Mellitus, Type 1 Diabetes; Cardiovascular Diseases (CVD); Severe Albuminuria; Estimated Glomerular Filtration Rate (eGFR); Hypoglycemia (Diabetic); Vascular Calcification; Carotid-femoral Pulse Wave Velocity; Kidney Diseases
Interventions: Drug: Routine/prescribed exogenous insulin dose
Sponsors: Rachel Miller; Juvenile Diabetes Research Foundation
Not yet recruiting

Ultrasound-guided Microwave Ablation of Benign Thyroid Nodules

November 02, 2026

Conditions: Thyroid Nodule (Diagnosis)
Interventions: Procedure: ultrasound-guided percutaneous microwave ablation (MWA)
Sponsors: Chinese University of Hong Kong
Recruiting

Lavender Inhalation for Anxiety in Patients Undergoing Coronary Angiography

October 30, 2026

Conditions: Anxiety; Coronary Angiography (CAG)
Interventions: Other: Lavender Essential Oil Inhalation
Sponsors: Betul Bayrak
Completed

Impact of Multidisciplinary Care, Structured and Targeted on the COPD Patient's Clinical Pathway.

October 30, 2026

Conditions: Chronic Obstructive Pulmonary Disease; Lung Diseases, Obstructive; Lung Disease Chronic
Interventions: Other: COPD targeted pharmaceutical interview and consultation; Other: Respiratory Insufficiency Day Hospitalization; Other: Pulmonary Function Test
Sponsors: Centre Hospitalier Universitaire de Nīmes; AstraZeneca
Not yet recruiting

Arterial Stiffness During Negative Pressure Wound Therapy for Abdominal Wall Wounds

October 30, 2026

Conditions: Postoperative Abdominal Wall Wound Complications; Surgical Wound Infection; Surgical Wound Dehiscence; Mesh-Associated Wound Complications
Interventions: Device: Negative Pressure Wound Therapy (NPWT)
Sponsors: Dávid Ágoston Kovács
Not yet recruiting

Cycling During Dialysis: A Feasibility and Safety Study

October 30, 2026

Conditions: Hemodialysis; Kidney Disease, End-Stage; Fatigue
Interventions: Behavioral: Supervised Intradialytic Cycling
Sponsors: Sunnybrook Health Sciences Centre
Not yet recruiting

Routine Magnesium Testing and Supplementation in Acute Heart Failure (MAG-HF)

October 30, 2026

Conditions: Acute Heart Failure (AHF)
Interventions: Other: No Routine Magnesium Testing or Supplementation; Other: Routine Magnesium Testing and Supplementation
Sponsors: University of Alberta
Not yet recruiting

Real-world Effectiveness and Safety of Savagen (Sacubitril/Valsartan) in Malaysian HFrEF Patients

October 30, 2026

Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF); Heart Failure
Interventions: Drug: Savagen (sacubitril/valsartan)
Sponsors: Sunway University
Not yet recruiting

Clinical Trial of Type II Collagen vs. Sodium Hyaluronate Intra-articular Injection in Knee Osteoarthritis

October 30, 2026

Conditions: Osteoarthritis; Osteoarthritis Knee Pain; Knee Arthritis
Interventions: Device: CartiSave; Drug: Hyalforte Injection
Sponsors: ATEMs
Completed

Associations of Postoperative Hemoglobin With AKI-AKD Trajectories

October 30, 2026

Conditions: Patients Undergoing Valvular Heart Surgery
Sponsors: Yonsei University
Active, not recruiting

Evaluation of Postoperative Organ Injury, Risk Factors, and Short-Term Clinical Outcomes in Patients Admitted to Intensive Care After Noncardiac Surgery

October 30, 2026

Conditions: Acute Kidney Injury; Postoperative Complications
Sponsors: Ankara Training and Research Hospital
Completed

Acupuncture Plus Mecobalamin for Diabetic Cardiac Autonomic Neuropathy

October 30, 2026

Conditions: Diabetic Cardiovascular Autonomic Neuropathy; Type 2 Diabetes Mellitus; Diabetic Neuropathies
Interventions: Procedure: Acupuncture; Drug: Mecobalamin
Sponsors: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recruiting

Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization

October 30, 2026

Conditions: Propofol; Ketamine; General Anesthetic Drug Adverse Reaction
Interventions: Drug: Ketamine-Propofol; Drug: Sevoflurane
Sponsors: Rawalpindi Institute of Cardiology
Recruiting

Development and Clinical Validation of Artificial Intelligence Algorithms for Sleep Staging and Obstructive Sleep Apnea Screening Based on a Large-Scale Model Trained on Multimodal Physiological Signals From Diverse Populations

October 30, 2026

Conditions: Sleep Apnea, Obstructive; Sleep Staging; Screening
Sponsors: Peking University First Hospital; Beijing Jinriyixiu Technology Co., Ltd.
Recruiting

Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis

October 30, 2026

Conditions: Giant Cell Arteritis (GCA); Acute Coronary Syndrome (ACS); Ishemic and Thrombotic Complications
Interventions: Drug: Acetyl Salicylic Acid (ASA); Drug: Placebo
Sponsors: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Not yet recruiting

Colchicine in Pulmonary Artery Hypertension Patients

October 30, 2026

Conditions: Pulmonary Hypertension
Interventions: Drug: Colchicine 0.5 MG Oral Tablet
Sponsors: Ain Shams University
Not yet recruiting

Sacituzumab Tirumotecan Plus Toripalimab for Advanced Penile Cancer After Platinum Chemotherapy

October 30, 2026

Conditions: Penile Squamous Cell Carcinoma (PSCC); Advanced Penile Cancer; Metastatic Penile Cancer; Locally Advanced Penile Cancer
Interventions: Drug: Sacituzumab Tirumotecan (SKB264); Drug: Toripalimab
Sponsors: Anhui Provincial Hospital
Not yet recruiting

Future School of Comprehensive Well-Being

October 30, 2026

Conditions: Learning; Comprehensive Wellbeing; Social Wellbeing; Physical Wellbeing; Mental Wellbeing; Pedagogical Practices; General Mental Health and Well-Being; Mental Disorders; Common Mental Disorders (CMD); Sedentary Behavior; Physical Inactivity; Depressive Symptom; Anxiety; Resilience, Psychological
Interventions: Behavioral: Comprehensive well-being pedagogy intervention for primary and lower secondary school students
Sponsors: University of Helsinki; Tampere University; University of Oulu; University of Jyvaskyla; University of Eastern Finland; JAMK University Of Applied Sciences
Active, not recruiting

The Effect of Remimazolam Tosylate on the Incidence of Postoperative Delirium in Older Patients Undergoing Cardiac Surgery: A Prospective Randomized Controlled Trial

October 30, 2026

Conditions: Delirium - Postoperative
Interventions: Drug: Remimazolam Tosylate; Drug: Propofol
Sponsors: Nanjing First Hospital, Nanjing Medical University
Recruiting

Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery

October 30, 2026

Conditions: Coronary Artery Disease; Left Ventricular Systolic Dysfunction; Gastric Contents
Interventions: Diagnostic Test: Gastric Ultrasonography
Sponsors: Adiyaman University
Not yet recruiting

A Study to Learn How Different Amounts of the Study Medicine Called PF-08161842 Are Tolerated and Act in the Body in Healthy and Older Adults

October 30, 2026

Conditions: Alzheimer Disease
Interventions: Drug: PF-08161842; Drug: Placebo for PF-08161842
Sponsors: Pfizer
Not yet recruiting

Clinical Evaluation of the Safety and Efficacy of "Buyan Huan Wu Tang" Combined With Atorvastatin in the Treatment of Atypical Pneumonia

October 30, 2026

Conditions: Moyamoya Disease
Interventions: Drug: Atorvastatin; Drug: Replenishing Five Herbs Decoction; Drug: Replenishing Five Herbs Decoction Placebo
Sponsors: The First Affiliated Hospital with Nanjing Medical University
Enrolling by invitation

Comparison of Task Trainer and Virtual Reality Approaches in Dysrhythmia Management Education

October 30, 2026

Conditions: Medical Education; Emergency Medicine; High-Fidelity Simulation Training; Virtual Reality Simulation
Interventions: Other: Virtual Reality-Based Dysrhythmia Management Training; Other: Task Trainer-Based Dysrhythmia Management Training
Sponsors: Karadeniz Technical University
Completed

Heat and Mental Health - PART 2

October 29, 2026

Conditions: Depressed Mood; Young Adults; Heat Stress; Sleep
Interventions: Other: Heat/Humidity Exposure Condition; Other: Thermoneutral Condition
Sponsors: Hartford Hospital; Yale University; University of Oxford
Recruiting

Metabolic Changes in Heart Failure Patients Treated With Vericiguat

October 29, 2026

Conditions: Heart Failure; Worsening Heart Failure; Heart Failure With Reduced Ejection Fraction
Interventions: Drug: Vericiguat
Sponsors: University of Salerno
Not yet recruiting

CATCH AF - Atrial Fibrillation Detection in Cryptogenic Stroke

October 29, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Device: CardioWatch 287-2 Group; Device: Control Group
Sponsors: Medical University of Graz
Not yet recruiting

The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest

October 29, 2026

Conditions: Cardiac Arrest, Out-Of-Hospital
Interventions: Device: Fixed PEEP Valve; Device: Sham Valve
Sponsors: Jeroen van Eijk; Dutch Heart Foundation; Ambu A/S
Active, not recruiting

Effects of Smartphone Use and Television Viewing on Standardized BP Measurement: The SCREENS-BP Study

October 29, 2026

Conditions: Hypertension
Interventions: Diagnostic Test: Standardized office blood pressure measurements
Sponsors: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Not yet recruiting

Diagnostic Value of Oropharyngeal Suction and Effect of Respiratory Physiotherapy on the Detection of Microorganisms in the Pediatric Patient

October 29, 2026

Conditions: Cystic Fibrosis (CF); Bronchiectasis, Non-Cystic Fibrosis
Interventions: Other: Respiratory physiothperapy; Other: Oropharyngeal suction; Other: Oropharyngeal swab; Other: Induced Sputum
Sponsors: Corporacion Parc Tauli
Recruiting

Pulsed Field Ablation of Atrial Fibrillation: CENTAURI Versus FARAPULSE

October 29, 2026

Conditions: Atrial Fibrillation; Paroxysmal Atrial Fibrillation; Persistent Atrial Fibrillation
Interventions: Device: CENTAURI PEF system; Device: FARAPULSE system
Sponsors: St. Anne's University Hospital Brno, Czech Republic
Completed

Vascular Health and Function in Cystic Fibrosis

October 29, 2026

Conditions: Cystic Fibrosis; Endothelial Dysfunction; Cardiovascular Risk Factor
Interventions: Other: Non-invasive vascular, cerebrovascular and autonomic assessment
Sponsors: Liverpool Heart and Chest Hospital NHS Foundation Trust
Not yet recruiting

A Comparison of Beta-blockers and Calcium Channel Blockers in Atrial Fibrillation

October 29, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Drug: Experimental intervention; Drug: Control Intervention
Sponsors: University Hospital, Basel, Switzerland; Swiss National Science Foundation; Schweizerische Herzstiftung; Freiwillige Akademische Gesellschaft Basel; Clinical Trial Unit, University Hospital Basel, Switzerland
Not yet recruiting

Effects of Different 432 Hz Auditory Stimuli on Physiological Stress Responses and Patient Satisfaction in Adults With Dental Anxiety During Restorative Treatment

October 29, 2026

Conditions: Dental Anxiety; Musical Therapy; Physiological Stress
Interventions: Behavioral: Music Therapy
Sponsors: Dokuz Eylul University
Completed

Assessment of the Prevalence of Rheumatic Heart Disease in School Settings in Mayotte and the Acquisition of Ultrasound Sequences Guided by Artificial Intelligence

October 29, 2026

Conditions: Rheumatic Heart Diseases; Scabies
Interventions: Device: Ultrasound performed bycardiologis for diagnosis of rheumatic heart disease
Sponsors: Centre Hospitalier Universitaire de la Réunion
Not yet recruiting

The Effect of Different Exercise Training Programs on Muscle Oxygenation in Individuals With Knee Osteoarthritis

October 29, 2026

Conditions: Osteoarthritis of Knee
Interventions: Other: Recumbent-Cycle Aerobic Exercise; Other: Lower-Limb Strengthening Exercise; Other: Home Flexibility Exercise Program
Sponsors: Bahçeşehir University; Istanbul University - Cerrahpasa; Istanbul Aydın University
Recruiting

Bedside Ultrasound in the Emergency Department for Predicting Acute Heart Failure Outcomes

October 29, 2026

Conditions: Acute Heart Failure (AHF); Heart Failure
Interventions: Diagnostic Test: Point-of-Care Ultrasound (POCUS) Protocol
Sponsors: Sakarya University
Completed

Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers

October 29, 2026

Conditions: Mood Disorders; Major Depressive Diorder; Bipolar Disorders; Mental Disorder
Sponsors: Korea University Anam Hospital
Not yet recruiting

Evaluation of the Performance and Safety of the Monobloc® - Silicone SoftOne® Breast Implants at 10 Years

October 29, 2026

Conditions: Breast Augmentation; Breast Reconstruction
Interventions: Device: Breast augmentation; Device: Breast reconstruction
Sponsors: Laboratoires ARION; EVAMED
Active, not recruiting

A Phase 1, First-in-Human Trial of BLN-481in Healthy Adult Participants

October 29, 2026

Conditions: Healthy Volunteers (no Disease Condition Under Study)
Interventions: Drug: Placebo; Drug: BLN-481
Sponsors: Beeline Medicines Corporation; Nucleus Network Ltd
Not yet recruiting

Iron Repletion in Cystic Fibrosis

October 29, 2026

Conditions: Cystic Fibrosis; Iron Deficiencies; Iron Deficiency Diseases
Interventions: Drug: IV Repletion; Drug: PO Repletion
Sponsors: University of Michigan; Cystic Fibrosis Foundation; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Under Pressure: Arugula Extract's Effect on Blood Pressure in Hypertensive Individuals

October 29, 2026

Conditions: Hypertension (HTN); Hypertension
Interventions: Dietary Supplement: Arugula Extract; Dietary Supplement: Psyllium Husk
Sponsors: Baylor University
Completed

SPX-01 Gene Therapy in Pediatric Patients With Spinal Muscular Atrophy Type 1 (RISE)

October 29, 2026

Conditions: Spinal Muscular Atrophy (SMA)
Interventions: Genetic: SPX-01
Sponsors: Exir Gene Pharmed
Not yet recruiting

Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults

October 29, 2026

Conditions: LGCMN; Large and Giant Congenital Melanocytic Nevi; NF1; Solid Tumor; Pediatric Tumors; Neurocutaneous Melanocytosis; Congenital Melanocytic Nevus; Arachnoid Cysts; Astrocytoma; Ependymoma; Melanoma
Interventions: Drug: Mirdametinib
Sponsors: National Cancer Institute (NCI)
Not yet recruiting

A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep Sedation

October 28, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Device: Catheter ablation; Drug: Deep sedation with midazolam and fentanyl or midazolam and remifentanil; Drug: Sedation with midazolam and fentanyl
Sponsors: East Sussex Healthcare NHS Trust
Recruiting

Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome

October 28, 2026

Conditions: Acute Coronary Syndromes (ACS)
Interventions: Other: Functional-Nutritional Burden
Sponsors: Samara State Medical University
Not yet recruiting

Generations for Heart Health

October 28, 2026

Conditions: Cardiovascular Health
Interventions: Device: Activity Tracker; Behavioral: Text Messages
Sponsors: NYU Langone Health; National Center for Advancing Translational Sciences (NCATS)
Not yet recruiting

Effectiveness of Virtual Reality in Improving Upper Limb Function in Critically Ill Patients

October 28, 2026

Conditions: Intensive Care Unit (ICU) Acquired Weakness (ICU - AW); Critical Illness
Interventions: Other: Conventional Physiotherapy and Occupational Therapy; Device: Fully Immersive Virtual Reality Training
Sponsors: National and Kapodistrian University of Athens; University of West Attica
Recruiting

OB VEGA-Phenylephrine vs Norepinephrine Outcomes

October 28, 2026

Conditions: Hypotension During Surgery; Cesarean Birth
Interventions: Drug: Phenylephrine; Drug: Norepinephrine
Sponsors: Wake Forest University Health Sciences
Not yet recruiting

Optimization of Two-Indicator Screening Protocol for Neonatal Congenital Heart Disease at High Altitude

October 28, 2026

Conditions: Neonatal Congenital Heart Disease
Sponsors: Children's Hospital of Fudan University; Qinghai Red Cross Hospital; Yan'an Affiliated Hospital of Kunming Medical University
Not yet recruiting

Effect of Stress Ball Use on Perioperative Anxiety and Postoperative Pain in Parturients Undergoing Cesarean Section

October 28, 2026

Conditions: Postoperative Pain
Interventions: Device: stress ball squeezing
Sponsors: The Second Affiliated Hospital of Chongqing Medical University
Not yet recruiting

Study of CTX001 in Adults With Anemia Due to Non-Dialysis-Dependent Chronic Kidney Disease

October 28, 2026

Conditions: Chronic Kidney Disease; Anemia
Interventions: Drug: Placebo; Drug: CTX001; Drug: Ferrous Sulfate
Sponsors: Cajal Therapeutics Inc.
Not yet recruiting

Xuanbai Yiqi Decoction for Sepsis: A Randomized Controlled Trial

October 28, 2026

Conditions: Sepsis
Interventions: Other: Xuanbai Chengqi Decoction; Other: Xuanbai Chengqi Decoction; Forest-Cultivated Ginseng; Other: Xuanbai Yiqi Decoction; Other: Inactive Chinese Herbal Decoction Placebo
Sponsors: Shanghai Jiao Tong University School of Medicine
Not yet recruiting

Sugammadex Timing and Recovery Profile in Pediatric Adenotonsillectomy

October 28, 2026

Conditions: Neuromuscular Blockade; Delayed Emergence From Anesthesia; Emergence Agitation
Sponsors: Namik Kemal University
Not yet recruiting

Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery

October 28, 2026

Conditions: Spinal Cord Neoplasms; Spinal Neoplasms
Interventions: Drug: Remimazolam; Drug: Propofol
Sponsors: Beijing Tsinghua Chang Gung Hospital
Not yet recruiting

Suture Choice for Ostomy Creation

October 28, 2026

Conditions: Ostomy - Ileostomy or Colostomy; Stoma Complications; Stoma Site Dermatitis; Stoma Site Infection; Peristomal Wound Infection; Peristomal Skin Complication; Stomal Bleeding; Stoma Site Incisional Hernia; Retraction of Colostomy; Retraction of Ileostomy; Stoma Malfunction
Interventions: Device: Chromic Gut Suture; Device: Polyglactin 910 Suture
Sponsors: University of Southern California
Not yet recruiting

A Clinical Study of MK-7962 in Chinese Participants With Pulmonary Arterial Hypertension (MK-7962-022)

October 28, 2026

Conditions: Hypertension, Pulmonary
Interventions: Biological: Sotatercept
Sponsors: Merck Sharp & Dohme LLC
Not yet recruiting

A Randomized, Double-blind, Placebo Controlled, Parallel Virtual Clinical Trial to Investigate the Efficacy of Marine Oil Products on Omega-3 Status in Healthy Adults

October 28, 2026

Conditions: Omega 3 Index; Nutrient Status; Healthy Adult Participants
Interventions: Dietary Supplement: Omega-3 Softgel; Dietary Supplement: Ultimate Omega Softgel; Dietary Supplement: Ultimate Omega 2X Softgel; Dietary Supplement: Ultimate Omega One Daily Softgel; Dietary Supplement: Ultimate Omega Plant-Based Softgel; Dietary Supplement: Ultimate Omega Liquid; Dietary Supplement: Omega-3 Liquid; Dietary Supplement: RO SE; Dietary Supplement: placebo softgel; Dietary Supplement: Placebo Liquid; Dietary Supplement: Ultimate Omega Mini; Dietary Supplement: Ultimate Omega Gummy Chew
Sponsors: Nordic Naturals; KGK Science Inc.
Recruiting

Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study

October 28, 2026

Conditions: Sepsis
Sponsors: Sir Run Run Shaw Hospital
Recruiting

A Research Study Looking at Kidney and Heart Health in Adults With Type 2 Diabetes and Chronic Kidney Disease Treated With Semaglutide in China

October 28, 2026

Conditions: Cardiovascular Risk; Chronic Kidney Disease
Interventions: Drug: Semaglutide
Sponsors: Novo Nordisk A/S
Recruiting

Phase 2b Efficacy and Safety Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients

October 28, 2026

Conditions: COPD; Chronic Obstructive Pulmonary Disease (COPD); Lung Disease Chronic; Lung Diseases, Obstructive
Interventions: Drug: AERO-001; Drug: AERO-002; Drug: AERO-007
Sponsors: AeroRx Therapeutics Inc.
Recruiting

Virtual Human Twins as Tools for Personalized Clinical Care in Heart Failure With Preserved Ejection Fraction: a Pilot Study

October 28, 2026

Conditions: Heart Failure
Interventions: Other: Data collection for the development and validation of the cardiovascular virtual human twin
Sponsors: Assistance Publique - Hôpitaux de Paris; University of Ghent, Belgium; University of Auckland, New Zealand; University of Maastricht, Netherlands; University of Delft, Netherlands; University of Pisa; Jagielloński University, Poland; Austrian Institute of Technology, Austria; IMEC, Netherlands; ELEM Biotech, Spain; WCR, Netherlands; École Polytechnique Fédérale de Lausanne, Switzerland; Kings College London, UK; University College London Hospitals
Not yet recruiting

LIfestyle MEtabotype Study B (LIME-B)

October 28, 2026

Conditions: Nutritional and Metabolic Diseases; Prediabetes; Type 2 Diabetes
Interventions: Dietary Supplement: βHB drink (ketone ester); Dietary Supplement: Carbohydrate drink
Sponsors: German Institute of Human Nutrition; Freie Universität Berlin, Center for Cognitive Neuroscience Berlin (CCNB); German Center of Diabetes Research (DZD)
Recruiting

Dual-Energy Lattice-Tip Assisted Marshall-Plan Strategy in Redo Persistent Atrial Fibrillation Ablation

October 28, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Procedure: Marshall Plan-Based Ablation Strategy; Procedure: PV re-isolation only; Procedure: Additional Left Atrial Ablation
Sponsors: Karolinska University Hospital
Not yet recruiting

A TwiCs Study of TCM Management Based on Cardiopulmonary Screening in COPD

October 28, 2026

Conditions: COPD With Coronary Artery Calcificatio
Interventions: Behavioral: TCM-Based Health Management Guided by Coronary Artery Calcium Scores
Sponsors: Henan University of Traditional Chinese Medicine
Not yet recruiting

Linvoseltamab Versus Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone (Dara-Vcd) in Adult Participants With Newly Diagnosed Systemic Light Chain Amyloidosis

October 28, 2026

Conditions: Newly Diagnosed Amyloidosis; Amyloidosis Stage I-IIIA
Interventions: Drug: Linvoseltamab; Drug: Daratumumab; Drug: Bortezomib; Drug: Cyclophosphamide; Drug: Dexamethasone
Sponsors: Regeneron Pharmaceuticals
Not yet recruiting

Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Insomnia During the Withdrawal-Rehabilitation Period of Methamphetamine Use Disorder

October 28, 2026

Conditions: Insomnia
Interventions: Device: taVNS; Device: sham-taVNS
Sponsors: The First Affiliated Hospital of Zhejiang Chinese Medical University
Not yet recruiting

Dural Puncture Epidural With 27G vs 26G Needles Versus Standard Epidural for Elective Cesarean Delivery

October 27, 2026

Conditions: Cesarean Section; Anesthesia, Obstetrical; Anesthesia, Epidural
Interventions: Procedure: Standard Epidural Anesthesia; Procedure: Dural Puncture Epidural With 27G Spinal Needle; Procedure: Dural Puncture Epidural With 26G Spinal Needle
Sponsors: Ankara City Hospital Bilkent
Not yet recruiting

Mazdutide for Reducing Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients

October 27, 2026

Conditions: Atrial Fibrillation (AF); Ablation Treatment; Obesity & Overweight; Mazdutide
Interventions: Drug: Mazdutide; Other: Conventional treatment
Sponsors: Beijing Anzhen Hospital
Not yet recruiting

Generative AI and Gamified Simulation-Based Train-the-Trainer Basic Life Support Training for High School Teachers in Vietnam

October 27, 2026

Conditions: Cardiac Arrest; Cardiopulmonary Resuscitation
Interventions: Behavioral: Generative AI and Gamified Simulation-Based Train-the-Trainer BLS Programme; Behavioral: Conventional Instructor-Led Simulation-Based BLS Training
Sponsors: Eastern International University; Burapha University
Not yet recruiting

Efficacy of Propranolol in Traumatic Brain Injury Patients Admitted to the ICU: A Prospective, Randomized, Triple-Blind Study

October 27, 2026

Conditions: Traumatic Brain Injury (TBI) Patients
Interventions: Drug: Propranolol + Placebo
Sponsors: Fundació d'investigació Sanitària de les Illes Balears
Recruiting

Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI

October 27, 2026

Conditions: No Reflow Phenomenon; Reperfusion Injuries, Myocardial; Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction; Coronary Artery Disease (CAD); PCI; Sodium Glucose Co-Transporter 2 Inhibitors; Empagliflozin; Dapagliflozin
Interventions: Drug: Empagliflozin (SGLT2i); Drug: dapagliflozin; Drug: Standard medical treatment
Sponsors: Al-Azhar University
Not yet recruiting

Therapeutic Outcomes of In-Hospital Resuscitation of Patients Admitted to the Internal Medicine Wards

October 27, 2026

Conditions: Survival to Discharge With Good Neurologic Outcome Among in Hospital Cardiac Arrest Patients
Sponsors: Meir Medical Center
Not yet recruiting

Reducing Slow/No-Reflow With Prophylactic High-Dose Intracoronary Adenosine Protocol in ST-Elevation Myocardial Infarction The REFLOW AMI Trial

October 27, 2026

Conditions: ST-Elevation Myocardial Infarction (STEMI)
Interventions: Drug: Adenosine; Other: Standard Treatment only
Sponsors: Prof Muzaffar Ali Zahidi
Recruiting

Cardiac Arrest - Ultrasound Detection of Occult Perfusion

October 27, 2026

Conditions: Cardiac Arrest, Out-Of-Hospital; Hypotension
Sponsors: University of Massachusetts, Worcester; Vanderbilt University School of Medicine; Dartmouth-Hitchcock Medical Center; University of Washington; Truman Medical Center; Icahn School of Medicine at Mount Sinai; MaineHealth; Hennepin Healthcare; University of Florida; University of Tennessee, Chattanooga; University of Kentucky; Maimonides Medical Center; Wake Forest University Health Sciences; University of Arkansas; Christiana Care Health Services; Beth Israel Deaconess Medical Center; Kaweah Delta Health Care District; SBH Health System; Brown University; Prisma Health Richland Hospital; University of Arizona; Boston Medical Center; University of Pittsburgh; Medical College of Wisconsin; State University of New York - Upstate Medical University; Denver Health Medical Center; Case Western Reserve University; Mayo Clinic; Hartford Hospital; advocate christ medical center; Virginia Commonwealth University; Stony Brook University
Recruiting

TRADENT Scoring Balloon Versus Non-scoring Balloon for Lesion Preparation in DCB-Based Coronary Intervention

October 27, 2026

Conditions: Coronary Artery Disease (CAD)
Interventions: Device: TRADENT Scoring Balloon; Device: Conventional Non-Scoring Coronary Balloon
Sponsors: Ulsan University Hospital; KangWon National University Hospital; Korea University Guro Hospital; Hanyang University Seoul Hospital; Kosin University Gospel Hospital; Chonnam National University Hospital; Gyeongsang National University Changwon Hospital
Not yet recruiting

Effects of Mounted vs Unmounted Human-Equine Interaction on Autistic Youth

October 27, 2026

Conditions: Autism Spectrum Disorder
Interventions: Behavioral: Mounted Human-equine Interaction; Behavioral: Unmounted Human-equine Interaction; Behavioral: No-Horse Control
Sponsors: Colorado State University
Completed

Study on the Mechanism of Central Obesity Induced by Sleep Restriction and the Therapeutic Effect of n-3 Polyunsaturated Fatty Acid: a Randomized, Double-blind, Placebo-controlled Trial (COSPA Study)

October 27, 2026

Conditions: Sleep Deprivation
Interventions: Dietary Supplement: n-3 PUFA Supplementation; Dietary Supplement: Placebo Supplementation; Behavioral: Experimental Sleep Restriction
Sponsors: Beijing Anzhen Hospital
Not yet recruiting

Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe Oligozoospermia

October 27, 2026

Conditions: Beta-hCG Positivity; Clinical Pregnancy; Miscarriage; Multiple Pregnancy; Ongoing Pregnancy; Live Birth Rates
Sponsors: Duzce University; T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi
Completed

FINtick - a Prospective Multicenter Study on Tick-borne Infections in Finland

October 27, 2026

Conditions: Tick Borne Encephalitis (TBE); Lyme Borreliosis; Neoehrlichiosis; Tick-Borne Diseases; Anaplasmosis; Babesiosis, Human; Rickettsia Infections; Borrelia Miyamotoi -Infection
Sponsors: Turku University Hospital; Helsinki University Central Hospital; Ålands hälso- och sjukvård ÅHS
Recruiting

Cardiac CT Angiography in Acute Stroke Imaging (SCOPE-CT)

October 27, 2026

Conditions: Acute Ischemic Stroke and Transient Ischemic Attacks
Interventions: Diagnostic Test: Cardiac CT Angiography
Sponsors: Ottawa Hospital Research Institute
Not yet recruiting

Superiority Assessment of Donor-derived Cell-FreE DNA ( Deoxyribonucleic Acid) for Cardiac Allograft REjection Monitoring

October 27, 2026

Conditions: Heart Transplantation
Interventions: Device: non-invasive strategy based of the analysis of circulating dd-cfDNA (AlloSeq cfDNA assay); Procedure: control
Sponsors: Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Investigating the Effects of 24 Hour LEAP2 Infusion in Individuals With Overweight and Obesity

October 27, 2026

Conditions: Obesity & Overweight
Interventions: Biological: Liver-expressed antimicrobial peptide 2; Other: Placebo
Sponsors: University Hospital, Gentofte, Copenhagen
Not yet recruiting

Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion

October 27, 2026

Conditions: Acute Ischemic Stroke; Basilar Artery Occlusion
Interventions: Procedure: Mechanical thrombectomy; Drug: Normothermic saline infusion; Drug: 4°C saline infusion
Sponsors: Guangdong Second Provincial General Hospital; The First Affiliated Hospital of University of Science and Technology of China
Not yet recruiting

Optimizing Care Transitions in CHD

October 27, 2026

Conditions: Congenital Heart Disease (CHD); Mentorship; Transition of Care; Peer Support; Peer Support and Chronic Disease; Adolescent; Young Adults; Parent
Interventions: Behavioral: Peer mentorship
Sponsors: The Hospital for Sick Children; Heart and Stroke Foundation of Canada
Not yet recruiting

Strap To Reduce Apnea in Preterm Infants: A Randomized Crossover Trial

October 27, 2026

Conditions: Apnea of Prematurity; Intermittent Hypoxemia; Bronchopulmonary Dysplasia of Newborn
Interventions: Device: Chinstrap
Sponsors: University of Alabama at Birmingham
Not yet recruiting

Efficacy and Safety of Xinyi Powder in Patients With Allergic Rhinitis and the Lung Deficiency and Cold Syndrome

October 27, 2026

Conditions: Allergic Rhinitis
Interventions: Drug: Xinyi Powder; Drug: Xinyi Powder placebo
Sponsors: Nanjing University of Traditional Chinese Medicine
Terminated

Impact of Significant Surgical Reduction of Adipose Tissue on Plasma Levels and Genetic Expression of Adipokines Associated With Ischemic Heart Disease in Type I Obesity.

October 27, 2026

Conditions: Obesity & Overweight; Obesity Type I and II
Interventions: Procedure: Liposuction
Sponsors: King Edward Medical University
Not yet recruiting

Tenecteplase in Acute Ischemic Stroke Under Different Transfer Models

October 27, 2026

Conditions: Acute Ischemic Stroke
Interventions: Drug: tenecteplase
Sponsors: Fujian Medical University Union Hospital; Zhangzhou Affiliated Hospital of Fujian Medical University
Not yet recruiting

Multimodal Monitoring During General Anesthesia in ENT Surgery

October 27, 2026

Conditions: General Anesthesia
Interventions: Device: Multimodal Anesthesia Monitoring (BIS, SPI, TOF); Other: Standard Anesthesia Monitoring
Sponsors: Barbara Verro; Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Completed

Dapagliflozin in Patients With Non-Obstructive Hypertrophic Cardiomyopathy: A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

October 27, 2026

Conditions: Nonobstructive Hypertrophic Cardiomyopathy
Interventions: Drug: Dapagliflozin 10mg; Drug: Dapagliflozin Placebo
Sponsors: Yonsei University
Not yet recruiting

Testing Settings of NovaResp's cMAP® Software During Home PAP Therapy

October 27, 2026

Conditions: Obstructive Sleep Apnea
Interventions: Device: Dynamic cMAP; Device: Direct cMAP
Sponsors: NovaResp Technologies Inc
Not yet recruiting

A Case-Control Study Revealing Intraocular Microenvironment Characteristics in Patients With Ocular Diseases Based on Multi-Omics Analysis

October 27, 2026

Conditions: Age- Related Macular Degeneration; Diabetic Retinopathy; Retinal Vein Occlusion; Central Serous Chorioretinopathy; Cataract
Interventions: Other: Not applicable- observational study
Sponsors: First Affiliated Hospital of Zhejiang University
Not yet recruiting

MRI-guided Ventricular Tachycardia Ablation in Patients With Structural Heart Disease

October 27, 2026

Conditions: Ventricular Tachycardia (VT); Ischemic Cardiomyopathy; Non-ischemic Cardiomyopathy
Interventions: Procedure: LGE-MRI-integrated EAM-guided catheter ablation; Procedure: Conventional EAM-guided catheter ablation
Sponsors: China National Center for Cardiovascular Diseases
Not yet recruiting

A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty

October 27, 2026

Conditions: Pain (Knee); Pain and Anxiety; TKA
Interventions: Behavioral: Heart rate variability biofeedback; Behavioral: Mindfulness; Behavioral: psychoeducation
Sponsors: Chang Gung Memorial Hospital
Recruiting

Mobile Clinic-Supported, Village Doctor-Led Screening and Integrated Care for Atrial Fibrillation and Heart Failure Comorbidity in Rural China (MOVE-AF HF)

October 27, 2026

Conditions: Atrial Fibrillation (AF); Heart Failure
Interventions: Behavioral: Mobile Clinic-Supported, Village Doctor-Led Screening and Integrated Care Group; Behavioral: Routine Management Group
Sponsors: Jiangsu Taizhou People's Hospital; The First Affiliated Hospital with Nanjing Medical University
Not yet recruiting

Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea With Complete Concentric Collapse

October 27, 2026

Conditions: Obstructive Sleep Apnea
Interventions: Device: Inspire Hypoglossal Nerve Stimulation System
Sponsors: Brigham and Women's Hospital; National Heart, Lung, and Blood Institute (NHLBI); Inspire Medical Systems, Inc.; Massachusetts Eye and Ear Infirmary
Not yet recruiting

The CORE Platform Trial

October 27, 2026

Conditions: Coronary Revascularization; Coronary Artery Disease
Interventions: Procedure: MIDCAB procedure; Procedure: CABG procedure
Sponsors: Copenhagen Trial Unit, Center for Clinical Intervention Research; Copenhagen University Hospital, Rigshospitalet; UMC Utrecht; Universitaire Ziekenhuizen KU Leuven
Not yet recruiting

Neqpiaput Iinruugut (Our Food Is Medicine): A Tribally Driven Food Sovereignty Intervention to Reduce Heart Disease Risk in Alaska Native Adults

October 27, 2026

Conditions: Cardiovascular (CV) Risk
Interventions: Behavioral: Neqpiaput linruugut (Our Food is Medicine)
Sponsors: University of Alaska Fairbanks; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

SGB for Prevention of Postop A-Fib After Cardiac SurgeryTrial

October 27, 2026

Conditions: Atrial Fibrillation; Postoperative Atrial Fibrillation
Interventions: Drug: Stellate Ganglion Block Injection with 10 mL 0.5% Bupivacaine; Drug: Stellate Ganglion Block Injection with 10 mL Normal Saline
Sponsors: The Cleveland Clinic
Not yet recruiting

Diagnosis of ECMO Cannula Infection: Prospective Comparison of Sampling Methods

October 26, 2026

Conditions: ECMO Cannula Infection; Extracorporel Membrane Oxygenation Complication
Sponsors: Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Renal Denervation in Patients With Atrial Fibrillation and Hypertension

October 26, 2026

Conditions: Atrial Fibrillation (Paroxysmal); Hypertension; Heart Failure With Preserved Ejection Fraction (HFPEF)
Interventions: Procedure: Catheter-based renal artery electrical stimulation (as a feasibility assessment for renal denervation)
Sponsors: Pavel Antiperovitch
Recruiting

Haemodynamic Effects of Four Sevoflurane Wash-In Strategies After Tracheal Intubation

October 26, 2026

Conditions: Anesthesia, General; Hypotension
Interventions: Other: End-tidal-controlled sevoflurane wash-in; Other: Low-flow high-concentration wash-in (0.5 L/min, 8% sevoflurane); Other: Low-flow wash-in (1 L/min, 4% sevoflurane); Other: Moderate-flow wash-in (2 L/min, 4% sevoflurane)
Sponsors: Ataturk University
Completed

EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)

October 26, 2026

Conditions: Heterozygous Familial Hypercholesterolemia (HeFH)
Interventions: Drug: Drug: EDIT-401; Other: Placebo
Sponsors: Editas Medicine, Inc.
Not yet recruiting

Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery

October 26, 2026

Conditions: Colorectal Cancer; Colorectal Neoplasms; Postoperative Complications
Interventions: Behavioral: Resistance Training Prehabilitation; Behavioral: Aerobic Training Prehabilitation; Other: Standard Trimodal Care
Sponsors: Semmelweis University
Recruiting

A Clinical Trial to Evaluate the Effects of the NeuEve Dryness Treatment Kit on Vaginal Health, Comfort, and Quality of Life in Postmenopausal Women

October 26, 2026

Conditions: Relieves Vaginal Dryness / Improves Self-Lubrication; Improves Strength & Elasticity of Vagina (Aka Collagen and Elastin); Improves Vaginal Wall Thickness; Reduces Pain During Sex; Reduces Vaginal Odor; Improves Vaginal Microbiome i.e. Increases Lactobacilli; Reduces Vaginal Itching, Improves Vaginal Burning & Discharge; Lowers Vaginal pH to 3.8-4.5; Improves Libido / Sexual Desire; Improves Orgasm / Sexual Satisfaction
Interventions: Dietary Supplement: Intervention
Sponsors: NeuEve; Citruslabs
Not yet recruiting

Cycling Within an Interactive and Immersive Virtual Environment During Critical Illness: a Patient-centred Approach for Lower Limb Rehabilitation

October 26, 2026

Conditions: Critical Illness
Interventions: Behavioral: Basic-Cycle; Behavioral: TV-Cycle; Behavioral: VR-Cycle
Sponsors: KU Leuven; Universitaire Ziekenhuizen KU Leuven
Recruiting

Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia

October 26, 2026

Conditions: Fibromyalgia (FM) OR Fibromyalgia Syndrome; Manuel Therapy; Chronic Widespread Pain; Autonomic Nervous System Dysfunction; taVNS
Interventions: Device: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS); Device: Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS); Other: Manual Therapy Program; Behavioral: Diaphragmatic Breathing and Stretching Exercises
Sponsors: Hasan Kalyoncu University
Not yet recruiting

Visual and Auditory Stimulation in Intensive Care Patients

October 26, 2026

Conditions: Dyspnea; Sleep Quality; Anxiety; Intensive Care Patients
Interventions: Other: The Northern Lights and White Noise
Sponsors: University of Yalova
Not yet recruiting

IMB-Guided Health Education Intervention for Medication Adherence and Blood Pressure Control in Non-adherent Hypertensive Patients

October 26, 2026

Conditions: Hypertension
Interventions: Behavioral: IMB Model-Guided Health Education Intervention; Behavioral: Usual Care
Sponsors: Bahir Dar University
Recruiting

Shiwei Anshen Granules for Chronic Insomnia

October 26, 2026

Conditions: Chronic Insomnia
Interventions: Drug: Shiwei Anshen granules; Drug: Placebo granules
Sponsors: Dongzhimen Hospital, Beijing; Shijiazhuang Pingan Hospital; Beijing Hospital of Traditional Chinese Medicine; Beijing Friendship Hospital; Beijing Fangshan District Hospital of Traditional Chinese Medicine; The Third Affiliated Hospital of Beijing University of Chinese Medicine; Beijing Changping District Hospital; Xiamen Hospital of Traditional Chinese Medicine; Capital Medical University; Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology; Beijing Xuanwu Traditional Chinese Medicine Hospital; Guangdong Provincial Hospital of Traditional Chinese Medicine; Beijing Longfu Hospital; Shunyi Hospital of Traditional Chinese Medicine
Not yet recruiting

Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest

October 26, 2026

Conditions: Out-of-Hospital Cardiac Arrest; Hypoxic-Ischemic Brain Injury; Post-Cardiac Arrest Syndrome
Interventions: Other: Minimal sedation; Other: Standard continuous sedation
Sponsors: University Medical Centre Ljubljana
Recruiting

Blood Pressure Goal in Preterm Preeclampsia

October 26, 2026

Conditions: Hypertensive Disorder of Pregnancy; Preeclampsia
Interventions: Other: Treating BP acutely with intravenous or rapid acting oral medications
Sponsors: Ohio State University
Not yet recruiting

The Effect of Probiotics in Infantile Colic

October 26, 2026

Conditions: Infantile Colic
Interventions: Dietary Supplement: Probiotic: L. reuteri DSM 17938 + BG-R46, total 2 × 10⁸ CFU/day; Dietary Supplement: Placebo: matching oil formulation without L. reuteri
Sponsors: Federico II University
Recruiting

Back Massage Before a Cognitive Task in Healthy Young Adults

October 26, 2026

Conditions: Cognitive Performance in Healthy Adults
Interventions: Other: Classical Back Massage; Behavioral: Passive Rest; Other: No Additional Break
Sponsors: DSW Ideis University; Wroclaw University of Health and Sport Sciences
Not yet recruiting

VR During Chest Tube Removal After CABG

October 26, 2026

Conditions: Coronary Artery Bypass Graft Surgery(CABG); Postoperative Pain Management
Interventions: Device: VR Shinecon G04EA Virtual Reality Headset
Sponsors: Maltepe University
Completed

Effects of Stress Ball Use During Femoral Catheter Removal After Coronary Angiography

October 26, 2026

Conditions: Coronary Angiography
Interventions: Other: Stress Ball Intervention
Sponsors: Maltepe University
Completed

Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and Sepsis

October 23, 2026

Conditions: Pneumonia; Sepsis; Blood Coagulation Disorders
Interventions: Drug: Placebo Tablet(s); Drug: DLBS1033
Sponsors: Universitas Sebelas Maret
Completed

Evaluation of the Effect of Regular Physical Exercise in Breast Cancer.

October 23, 2026

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Interventions: Other: Supervised exercise program
Sponsors: Fundación Investigación E Innovación Biomédica Hospital Universitario Infanta Sofia-Henares; IMDEA Food; Fundación General CSIC; Universidad Politecnica de Madrid
Recruiting

EEG As a Genetic Selection Lever in Autism Spectrum Disorder

October 23, 2026

Conditions: Autism Spectrum Disorder (ASD
Interventions: Other: Collection of routine care data
Sponsors: Centre Hospitalier Régional Metz-Thionville
Not yet recruiting

Effect of High Intensity Aerobic Exercise on Pain Threshold and Blood Pressure in Females With Primary Dysmenorrhea

October 23, 2026

Conditions: Primary Dysmenorrhea
Interventions: Other: High Intensity Aerobic Exercise
Sponsors: Lincoln University College; Lincoln University College Malaysia; Universiti Tunku Abdul Rahman
Completed

Creatine and Muscle Health in Madrid's Walking Footballers.

October 23, 2026

Conditions: Muscle Adaptation; Body Composition; Physical Activity in Adults
Interventions: Dietary Supplement: Monohydrate Creatine supplementation during Walking Football training
Sponsors: Universidad Europea de Madrid; Universidad Politecnica de Madrid; Crown Sport Nutrition
Not yet recruiting

Methadone Administration in Critically Ill Patients in the Intensive Care Unit and Risk of Prolonged QTc and Cardiac Arrythmia

October 23, 2026

Conditions: Patients Treated With Methadone
Interventions: Drug: ICU patients treated with methadone
Sponsors: Meir Medical Center
Not yet recruiting

Individual Variability in Energy Compensation After a 12-Week Supervised Exercise Intervention

October 23, 2026

Conditions: Physical Inactivity; Overweight; Obesity
Interventions: Behavioral: Supervised Aerobic Exercise Programme
Sponsors: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Not yet recruiting

Ceritinib Treatment for Recurrent Meningiomas

October 23, 2026

Conditions: Recurrent Meningioma, Grade I and Grade II
Interventions: Drug: Ceritinib
Sponsors: Kevin Petrecca
Not yet recruiting

Reducing Arterial Inflammation Using Eplerenone and Statins in HIV

October 23, 2026

Conditions: HIV (Human Immunodeficiency Virus); Cardiovascular Diseases (CVD); Arterial Inflammation; Heart Disease
Interventions: Drug: Eplerenone; Drug: Placebo
Sponsors: Massachusetts General Hospital; University of California, Los Angeles (UCLA Health)
Not yet recruiting

Trastuzumab Rezetecan Followed by Pyrotinib, Fulvestrant, and Dalpiciclib in HR-Positive, HER2-Positive Advanced Breast Cancer

October 23, 2026

Conditions: Metastatic Breast Cancer (MBC); HER2-Positive Breast Cancer; Hormone Receptor-Positive Breast Cancer
Interventions: Drug: Fulvestrant; Drug: Pyrotinib; Drug: Dalpiciclib; Drug: Trastuzumab Rezetecan
Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Not yet recruiting

Type 2 Inflammation in Adults With Cystic Fibrosis

October 23, 2026

Conditions: Cystic Fibrosis (CF); Type 2 Inflammatory Disorders
Sponsors: University of Virginia; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health

October 23, 2026

Conditions: Inflammation; Depression Disorder; Mindfulness; Emotional Well-being; Physical Health; Mental Health
Interventions: Behavioral: Mindfulness-based cognitive therapy for perinatal depression; Behavioral: Pregnancy Health Group
Sponsors: Oregon Health and Science University; National Center for Complementary and Integrative Health (NCCIH)
Not yet recruiting

Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium

October 23, 2026

Conditions: Cardiac Surgery With Cardiopulmonary Bypass; Postoperative Delirium
Interventions: Drug: Intranasal insulin-20U; Drug: Intranasal insulin-40U; Drug: Intranasal Saline
Sponsors: Fujian Medical University Union Hospital
Recruiting

Wearable Ultrasound for Cardiac Monitoring During Surgery and in Intensive Care

October 23, 2026

Conditions: Cardiovascular Diseases
Interventions: Device: Wearable Ultrasound Imaging System
Sponsors: China National Center for Cardiovascular Diseases
Not yet recruiting

Complementary Exercise-Based Therapy for Obstructive Sleep Apnea

October 23, 2026

Conditions: Obstructive Sleep Apnea
Interventions: Behavioral: Multimodal Exercise, Respiratory and Cervical-Postural Rehabilitation Program; Device: Continuous Positive Airway Pressure (CPAP)
Sponsors: bioROne
Completed

Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation

October 23, 2026

Conditions: Atrial Fibrillation (AF); Cerebral Vascular Accident (CVA); Heart Failure; Myocardial Infarction (MI)
Interventions: Other: tVNS session on the left earlobe; Other: tVNS "SHAM" session the conchae aurea of the left ear
Sponsors: Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting

Adding Preoperative Radiotherapy Based on Early Treatment Response in Breast Cancer

October 23, 2026

Conditions: Invasive Breast Cancer
Interventions: Radiation: Response-adapted preoperative radiotherapy; Other: Guideline-recommended neoadjuvant systemic therapy; Diagnostic Test: Serial contrast-enhanced breast MRI and breast-specific gamma imaging
Sponsors: Second Affiliated Hospital, Zhejiang University, School of Medicine
Not yet recruiting

Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension

October 22, 2026

Conditions: Resistant Hypertension; Kidney Failure, Chronic; Hemodialysis
Interventions: Drug: Spironolactone
Sponsors: Universitas Sebelas Maret
Completed

Bone Health in Adults With Duchenne Muscular Dystrophy: A Survey on Osteoporosis, Fractures and Treatment.

October 22, 2026

Conditions: Duchenne Muscular Dystrophy (DMD)
Sponsors: Istituto Giannina Gaslini
Recruiting

Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy

October 22, 2026

Conditions: Epilepsy; Hypothalamus; Seizures- Cardiac Dysautonomia; SUDEP
Interventions: Other: MRI scan; Other: electrocardiogram
Sponsors: Centre Hospitalier Universitaire, Amiens
Recruiting

The Development and Optimization of a Cardiac Magnetic Resonance Imaging Protocol in a 3 Tesla Scanner

October 22, 2026

Conditions: Cardiac Failure
Sponsors: Wang . Jiun-Jie
Completed

Integrated Assessment of Immune-Inflammatory and Metabolic Biomarkers for Prediction of Coronary No-Reflow Following Primary PCI in STEMI Patients

October 22, 2026

Conditions: Integrated Assessment; Immune-Inflammatory; Metabolic Biomarkers; Coronary No-Reflow; Primary Percutaneous Coronary Intervention; ST Segment Elevation Myocardial Infarction
Interventions: Diagnostic Test: Assessment of immune-inflammatory and metabolic biomarkers
Sponsors: Sohag University
Recruiting

MCG Algorithm Optimization Study in Patients With Coronary Artery Stenosis

October 22, 2026

Conditions: Coronary Artery Disease
Sponsors: AMCG
Not yet recruiting

Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of Stay

October 22, 2026

Conditions: Suicidal Ideation; Suicidal Behavior
Interventions: Drug: Esketamine; Drug: Midazolam (Intravenous)
Sponsors: University of Sao Paulo
Not yet recruiting

Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve Surgery

October 22, 2026

Conditions: Heart Valve Surgery; Acute Kidney Injury
Interventions: Device: remote ischemic preconditioning
Sponsors: Fujian Medical University Union Hospital
Recruiting

Impact of Telepharmacy on Hemodialysis Outcomes

October 22, 2026

Conditions: Anemia; Hemodialysis
Interventions: Other: Routine Standard Care; Behavioral: Telepharmacy Intervention
Sponsors: Damanhour University
Completed

Replacing Spatial Filtering With Deep-learning Noise Reduction

October 22, 2026

Conditions: Cardiac Disease
Sponsors: Central Hospital, Nancy, France
Not yet recruiting

Superficial Parasternal Block Combined With Rectus Sheath Block for Open Cardiac Surgery

October 22, 2026

Conditions: Cardiac Valve Disease; Coronary Heart Disease
Interventions: Drug: Parasternal and rectus sheath block, ropivacaine 0.25 %
Sponsors: Hôpital du Valais; University of Lausanne Hospitals
Not yet recruiting

Conduction Breakthrough in the Coronary Sinus Post Endocardial Mitral Isthmus Ablation

October 22, 2026

Conditions: Atrial Fibrillation (AF); Atrial Tachycardia; Paroxysmal AF; Persisent Atrial Fibrillation
Sponsors: Sebastien Knecht
Not yet recruiting

Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest

October 22, 2026

Conditions: Cardiac Arrest (CA)
Sponsors: Children's Hospital of Philadelphia; National Heart, Lung, and Blood Institute (NHLBI); University of Utah; Villanova University
Recruiting