Gut Oxygen Therapy for Ischemic-Hypoxic Bowel Disease

June 02, 2026

Conditions: Ischemic Bowel Disease; Hypoxic Events
Interventions: Other: Oxygen 30 %; Other: Air
Sponsors: The Second Hospital of Nanjing Medical University
Recruiting

VR for Cataract Anxiety Lowering Management--A RCT Study

June 02, 2026

Conditions: Cataract and IOL Surgery; VR-based Informed Consent
Interventions: Device: Virtual reality simulation of intraoperative audiovisual experience
Sponsors: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Not yet recruiting

MTM2MTG Pilot Ancillary Study

June 02, 2026

Conditions: Diet, Healthy; HbA1c; Blood Pressure
Interventions: Behavioral: Medically Tailored Groceries
Sponsors: Columbia University
Enrolling by invitation

Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Incretin Receptor Agonists

June 02, 2026

Conditions: Obesity & Overweight
Interventions: Device: transcutaneous auricular vagus nerve stimulation; Device: Sham
Sponsors: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recruiting

The Bone and hEArt Health Consequences of Ovarian agiNg (BEACON) Study

June 02, 2026

Conditions: Ovarian Aging; Adverse Pregnancy Outcomes
Sponsors: Indiana University
Not yet recruiting

Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS)

June 02, 2026

Conditions: Chronic Fatigue Syndrome
Interventions: Device: Hyperbaric oxygen therapy; Device: SHAM treatment
Sponsors: Assaf-Harofeh Medical Center
Not yet recruiting

Effect of Guanxinning Tablet on Coronary Microcirculation After Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction

June 02, 2026

Conditions: STEMI (ST Elevation MI); STEMI - ST Elevation Myocardial Infarction; STEMI; CMD; Coronary Microvascular Dysfunction (CMD)
Interventions: Drug: Guanxinning Tablet(GXNT); Drug: Placebo
Sponsors: Beijing Anzhen Hospital
Not yet recruiting

Bubble CPAP Team-Based Care Strategy Feasibility Trial

June 02, 2026

Conditions: Pneumonia in Children
Interventions: Behavioral: bCPAP team-based care strategy
Sponsors: Yale University; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Variable Intense Training for Ataxia and Locomotion

June 02, 2026

Conditions: Cerebellar Disorders; Cerebellar Degeneration; Cerebellar Atrophy; Cerebellar Lesions
Interventions: Other: High-intensity training in variable contexts; Other: Conventional balance training
Sponsors: Indiana University; Rehabilitation Hospital of Indiana
Not yet recruiting

Mechanical Power for Ventilatory Settings in Operating Room

June 02, 2026

Conditions: Postoperative Respiratory Failure; Abdominal Surgery; Postoperative Pulmonary Complications; Morality
Interventions: Procedure: Mechanical power-guided ventilatory strategy; Procedure: Standard fixed ventilatory settings
Sponsors: University Hospital, Montpellier
Not yet recruiting

Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism

June 02, 2026

Conditions: Primary Aldosteronism
Interventions: Diagnostic Test: Saline Infusion Test
Sponsors: Seoul National University Hospital; Gangneung Asan Hospital; Nowon Eulji Medical Center; Inha University Hospital; Asan Medical Center; Samsung Medical Center; Eunpyeong St. Mary's Hospital; Chungnam National University Hospital; Kangbuk Samsung Hospital; Ajou University School of Medicine; Hallym University Dongtan Sacred Heart Hospital; DongGuk University; Korea University Guro Hospital; Chonnam National University Hospital
Recruiting

Machine Learning for Diagnosis of Occlusive MI in LBBB Patients

June 02, 2026

Conditions: Acute Myocardial Infarction (AMI); Left Bundle Branch Block; Coronary Occlusion/Thrombosis; Chest Pain; Myocardial Infarction
Interventions: Other: Digital 12-Lead ECG Analysis and Invasive Coronary Angiography
Sponsors: Konya City Hospital
Recruiting

PULSed Field Ablation for Atrial Fibrillation Using a Balloon for Early Intervention - Study

June 02, 2026

Conditions: Atrial Fibrillation
Interventions: Procedure: Ablation of atrial fibrillation (AF)
Sponsors: Asklepios proresearch; Atrial Fibrillation Network; Abbott
Not yet recruiting

VOLta Medical AI-software in REal-World During AF Ablation

June 02, 2026

Conditions: Atrial Fibrillation; Atrial Arrhythmia; Arrhythmias, Cardiac
Interventions: Device: Cardiac mapping
Sponsors: Volta Medical
Not yet recruiting

Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)

June 02, 2026

Conditions: Obesity; Metabolic Syndrome; Brown Adipose Tissue
Interventions: Drug: Semaglutide (Wegovy®); Procedure: ¹⁸FDG-PET/CT with cold stimulation; Procedure: Liver MRI (PDFF + MRE)
Sponsors: Hallym University; Hallym University Dongtan Sacred Heart Hospital
Not yet recruiting

KONECT RESILIA Aortic Valved Conduit (AVC) Real-world Study Assessing Safety and Performance

June 02, 2026

Conditions: Aortic Valve Disease
Interventions: Device: Edwards KONECT RESILIA AVC
Sponsors: Edwards Lifesciences
Not yet recruiting

Breathwork and Mindfulness Interventions on Psychological Flexibility: A 4-Arm RCT

June 02, 2026

Conditions: Anxiety; Psychological Flexibility; Stress
Interventions: Behavioral: Box Breathing; Behavioral: Cyclic Sighing; Behavioral: Mindfulness AH Exhalation; Behavioral: Mindful Cyclic Sighing
Sponsors: Valencian International University (VIU)
Not yet recruiting

Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.

June 02, 2026

Conditions: Obesity; Overweight
Interventions: Drug: Tirzepatide; Drug: Semaglutide
Sponsors: Brigham and Women's Hospital
Active, not recruiting

Effects of New Zealand Blackcurrant Supplementation on Exercise and Cognitive Performance in Resistance-Trained Adults

June 02, 2026

Conditions: Resistance Exercise Performance; Cognitive Function; Anaerobic Performance; Dietary Supplementation Athletic Performance
Interventions: Dietary Supplement: Low-dose Blackcurrant Supplement; Dietary Supplement: High-dose Blackcurrant Supplement; Dietary Supplement: Maltodextrin (Placebo)
Sponsors: Jacksonville State University
Completed

Spectral Precise Image Study for Coronary Artery

June 02, 2026

Conditions: Cardiac
Interventions: Device: Non-Interventional Study; Device: Non-Interventional Study
Sponsors: Philips Clinical & Medical Affairs Global; The First Affiliated Hospital of Zhengzhou University
Not yet recruiting

To Compare the Pharmacodynamic and Short-term Clinical Effects of Standard DAPT, DAPT With Half-dose Ticagrelor, and Aspirin-free Half-dose Ticagrelor Monotherapy From the Day of PCI in Chronic Coronary Syndrome (CCS)

June 02, 2026

Conditions: Chronic Coronary Syndrome; Coronary Artery Disease; Percutaneous Coronary Intervention
Interventions: Drug: Aspirin 100 mg + ticagrelor (90 mg load → 45 mg twice daily) ×6 months, then aspirin monotherapy; Drug: Ticagrelor (90 mg load → 45 mg twice daily) monotherapy; aspirin stopped at day 2 after randomisation; continued indefinitely; Drug: Aspirin 100 mg + clopidogrel (300 mg load → 75 mg daily) ×6 months, then aspirin monotherapy
Sponsors: Kaohsiung Veterans General Hospital.
Completed

The Pharmacokinetics and Pharmacodynamics Study of CG-0255 Besylate and Plavix® in Healthy Participants

June 02, 2026

Conditions: Acute Coronary Syndromes (ACS); Recent Myocardial Infarction; Recent Stroke; Peripheral Arterial Disease
Interventions: Drug: CG-0255 Besylate for Injection; Drug: CG-0255 Besylate Capsule; Drug: Clopidogrel
Sponsors: Shanghai CureGene Pharmaceutical Co., Ltd.
Not yet recruiting

Injectable Semaglutide vs Dulaglutide in Individuals at Cardiovascular Risk

June 02, 2026

Conditions: Type 2 Diabetes Mellitus; Obesity; Overweight
Interventions: Drug: Semaglutide; Drug: Dulaglutide
Sponsors: Brigham and Women's Hospital
Active, not recruiting

Deep Sedation vs. General Anesthesia for Pulsed Field Ablation in Atrial Fibrillation

June 02, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Procedure: Standardized Deep Sedation Protocol; Procedure: Standard General Anesthesia
Sponsors: Second Affiliated Hospital of Nanchang University
Not yet recruiting

Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome

June 02, 2026

Conditions: Metabolic Syndrome; Prediabetes
Interventions: Behavioral: Postprandial walking; Behavioral: Brief resistance exercise snacks
Sponsors: Seoul National University
Not yet recruiting

Manual vs Pneumatic Compression to Prevent Radial Artery Occlusion After Transradial Procedures

June 02, 2026

Conditions: Radial Artery Occlusion; Cardiac Catheterization
Interventions: Procedure: Manual Radial Compression; Device: Pneumatic Radial Compression Device
Sponsors: Hospital Clinic of Barcelona
Completed

Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Western Lithuania 2022-2028

June 02, 2026

Conditions: Out-of-hospital Cardiac Arrest (OHCA)
Interventions: Behavioral: Protocol based
Sponsors: Lithuanian University of Health Sciences
Not yet recruiting

High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Phase II Cardiac Rehabilitation

June 02, 2026

Conditions: Coronary Artery Disease
Interventions: Behavioral: High-Intensity Interval Training; Behavioral: Moderate-Intensity Continuous Training
Sponsors: Riphah International University
Not yet recruiting

Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a, for Advanced Pancreatic Ductal Adenocarcinoma

June 02, 2026

Conditions: Advanced Pancreatic Ductal Adenocarcinoma; Metastatic Pancreatic Ductal Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Pancreatic Ductal Adenocarcinoma
Interventions: Procedure: Biospecimen Collection; Procedure: Diagnostic Imaging Testing; Procedure: Echocardiography Test; Procedure: Multigated Acquisition Scan; Drug: Selumetinib; Biological: Trastuzumab Deruxtecan
Sponsors: National Cancer Institute (NCI)
Not yet recruiting

Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study

June 02, 2026

Conditions: Aortic Stenosis; Chronic Coronary Syndrome; Calcific Aortic Valve Disease; Calcific Aortic Stenosis
Interventions: Diagnostic Test: Echocardiography and Cardiac CT
Sponsors: Azienda Ospedaliera "Sant'Andrea"; Politecnico di Milano; Centro Cardiologico Monzino; I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio; University of Bologna
Recruiting

ProGo Menopause Wellbeing Study

June 02, 2026

Conditions: Menopause Related Conditions
Interventions: Dietary Supplement: Salmon protein hydrolysate (SPH) powder formulated into a tablet format; Dietary Supplement: Microcrystalline Cellulose
Sponsors: Hofseth Biocare ASA; Alethios, Inc.
Not yet recruiting

Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department

June 02, 2026

Conditions: Peri-intubation Hypotension; Rapid Sequence Intubation
Interventions: Drug: Adrenaline; Drug: 0.9 % sodium chloride
Sponsors: Marmara University Pendik Training and Research Hospital
Not yet recruiting

Pulsed Field Ablation Versus Radiofrequency Ablation: Effects of Pulmonary Vein Isolation Combined With Left Atrial Posterior Wall Isolation on Postoperative Gastric Motility in Patients With Persistent Atrial Fibrillation

June 02, 2026

Conditions: Persistent Atrial Fibrillation
Interventions: Procedure: Pulsed Field Ablation; Procedure: Radiofrequency Ablation
Sponsors: Xijing Hospital
Not yet recruiting

Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery,

June 02, 2026

Conditions: Anesthesia; Pulmonary Hypertension; Chronic Pulmonary Thromboembolism; Vasopressor
Interventions: Drug: Vasopressin; Drug: Norepinephrine
Sponsors: Fondation Hôpital Saint-Joseph
Not yet recruiting

Recovery Trajectory for Coma and Disorders of Consciousness

June 02, 2026

Conditions: Coma; Disorders of Consciousness; Cardiac Arrest (CA); Traumatic Brain Injuries; Ischemic Stroke; Hemorrhagic Stroke, Intracerebral; Meningitis/Encephalitis; Status Epilepticus
Sponsors: University of California, San Francisco; Zuckerberg San Francisco General Hospital and Trauma Center
Recruiting

Evaluation of Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74 PET/CT Imaging)

June 02, 2026

Conditions: Allogeneic Stem Cell Transplantation; Lung Allograft Transplantation; Interstitial Lung Disease; Acute Lung Injury; Pulmonary Arterial Hypertension; Cardiovascular Diseases
Interventions: Diagnostic Test: 18F-FAPI-74 PET/CT Imaging; Drug: [18F]FAPI-74
Sponsors: National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

High-Flow Nasal Cannula on Exercise Tolerance in Heart Failure Patients Undergoing Cardiac Rehabilitation

June 02, 2026

Conditions: Heart Failure; Exercise Tolerance (Measured in Minutes); Cardiac Rehabilitation
Interventions: Device: High-Flow Nasal Cannula (HFNC)
Sponsors: Universidad de Santiago de Chile
Not yet recruiting

Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study

June 02, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Device: Remapping Procedure
Sponsors: Northwell Health; Boston Scientific Corporation
Recruiting

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

June 02, 2026

Conditions: Sickle Cell Disease; Beta-thalassemia
Interventions: Radiation: Total Body Irradiation; Drug: Alemtuzumab; Drug: Abatacept; Other: Research blood draw
Sponsors: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

The Efficacy and Safety of Inpegsomatropin Injection in Children With Turner Syndrome (TS) and Short Stature

June 02, 2026

Conditions: Turner Syndrome
Interventions: Drug: Inpegsomatropin-Injection; Drug: Givopegsomatropin Solution Injection
Sponsors: Xiamen Amoytop Biotech Co., Ltd.
Not yet recruiting

BIO|STREAM.CSP CLS

June 02, 2026

Conditions: Sinus Node Disease; Atrioventricular Block
Interventions: Device: Left bundle branch area pacing with Closed Loop Stimulation
Sponsors: Biotronik SE & Co. KG
Recruiting

Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions

June 01, 2026

Conditions: Myocardial Infarction; Decompensated Chronic Heart Failure; Acute Heart Failure (AHF); Pulmonary Embolism Acute; Hypertension Emergency; Arrhythmias
Interventions: Biological: Influenza vaccination
Sponsors: Wroclaw Medical University
Recruiting

Stepwise vs Standard Anticoagulation for AF Patients Undergoing CIED Implantation (STEP-AF)

June 01, 2026

Conditions: Non-valvular Atrial Fibrillation (NVAF); Thromboembolism; Cardiac Implantable Electronic Device; Perioperative Bleeding; Hematoma Postoperative
Interventions: Drug: Stepwise Anticoagulation Regimen; Drug: Standard Anticoagulation Regimen
Sponsors: Fu Wai Hospital, Beijing, China; Peking University First Hospital; Fuwai Shenzhen Hospital; Beijing Boai Hospital, China Rehabilitation Research Center
Not yet recruiting

A Phase I Study of INT-210 Capsules in Healthy Adult Subjects (INT-210-I101)

June 01, 2026

Conditions: IBD (Inflammatory Bowel Disease)
Interventions: Drug: INT-210 Capsule; Drug: INT-210 Capsule; Drug: INT-210 Capsule; Drug: INT-210 Placebo
Sponsors: Innatus Therapeutics (Shanghai) Co., Ltd.
Completed

Clinical Study of Chinese Herbal Compound Qidan Xiaoke Granules in Patients After Coronary Revascularization

June 01, 2026

Conditions: Percutaneous Coronary Intervention; Myocardial Revascularization; Coronary Artery Disease
Interventions: Drug: Qidan Xiaoke Granules + Standard Medical Therapy; Drug: Placebo + Standard Medical Therapy
Sponsors: Liu Qiang
Not yet recruiting

Stereotactic Radioablation as First-Line Therapy for Scar-Related Ventricular Tachycardia

June 01, 2026

Conditions: Ventricular Tachycardia, Monomorphic; Cardiomyopathies
Interventions: Radiation: Stereotactic Arrhythmia Radioablation
Sponsors: Southlake Health
Not yet recruiting

Comparison of the Effectiveness of Two Different Methods in Reducing Pain and Anxiety

June 01, 2026

Conditions: Stress; Pain, Acute
Interventions: Behavioral: stress ball; Behavioral: breathing exercises
Sponsors: Celal Bayar University
Completed

Flow-Based Platelet Function (T-TAS) and Early Bleeding After Cardiac Surgery

June 01, 2026

Conditions: Perioperative Bleeding; Coagulopathy During Cardiac Surgery; Platelet Dysfunction; Cardiac Surgery; Acquired Von Willebrand Disease
Interventions: Diagnostic Test: Total Thrombus-formation Analysis System (T-TAS)
Sponsors: Hospital de la Santa creu i Sant Pau - Barcelona
Not yet recruiting

Correlation and Prognostic Value of Body Composition, Cardiac Structure and Function in Patients With Different Heart Failure Subtypes

June 01, 2026

Conditions: Heart Failure
Sponsors: Beijing Anzhen Hospital
Not yet recruiting

A Phase I SAD/MAD and Liver Effect Study of Vitalangio in Venous Thromboembolism Patients .

June 01, 2026

Conditions: Thrombosis; Cardiovascular Diseases
Interventions: Drug: Placebo Comparator: Single dose group; Drug: Experimental: Food effect group; Drug: Active Comparator: Multiple dose group
Sponsors: Peking University First Hospital
Completed

Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study

June 01, 2026

Conditions: Atrial Fibrillation (AF); Tricuspid Regurgitation (TR)
Sponsors: Centro Cardiologico Monzino; Istituto Clinico Humanitas
Recruiting

Changing Outpatient Diabetes Care With Remote-Patient-Monitoring: A Real World Evidence Study With Pre-Post Comparison

June 01, 2026

Conditions: Diabetes; Diabetes Care; Diabetes Type 1; Diabetes Type 2; Remote Patient Monitoring; Digital Health
Interventions: Other: Remote-Patient-Monitoring (RPM)
Sponsors: Steno Diabetes Center Copenhagen
Not yet recruiting

Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD)

June 01, 2026

Conditions: Post Traumatic Stress Disorder
Interventions: Procedure: Stellate ganglion block
Sponsors: sara dichtwald
Not yet recruiting

Effect of Vestibular Rehabilitation on Postural Sway and Energy Expenditure in Children With Spastic Diplegia

June 01, 2026

Conditions: Spastic Diplegia
Interventions: Other: vestibular rehabilitation; Other: conventional physical therapy
Sponsors: Cairo University
Not yet recruiting

Multimodal mAgnetic Resonance imaGIng in Cardiovascular Disease

June 01, 2026

Conditions: Cardiovascular Diseases; Ischemic Heart Disease (IHD); Cardiomyopathy; Myocarditis; Heart Valve Diseases
Interventions: Diagnostic Test: Multi-modal Cardiac Magnetic Resonance
Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)

June 01, 2026

Conditions: AKI - Acute Kidney Injury; Cardiac Surgical Procedures; Cardiopulmonary Bypass
Interventions: Drug: Recombinant Human Brain Natriuretic Peptide (rhBNP); Drug: Normal Saline (Placebo)
Sponsors: China National Center for Cardiovascular Diseases; The First Affiliated Hospital of Xiamen University; Guangdong Provincial People's Hospital; Yantai Yuhuangding Hospital; Second Xiangya Hospital of Central South University; First Affiliated Hospital of Chongqing Medical University; Shenzhen Sun Yat-sen Cardiovascular Hospital
Not yet recruiting

NASVAL-SVT: Nasal Swab Versus Modified Valsalva for Supraventricular Tachycardia

June 01, 2026

Conditions: Supraventricular Tachycardia; Paroxysmal Supraventricular Tachycardia; Atrioventricular Nodal Reentry Tachycardia; Vagal Maneuver
Interventions: Procedure: Nasopharyngeal Swab Insertion; Procedure: Modified Valsalva Maneuver (REVERT Protocol)
Sponsors: Marmara University Pendik Training and Research Hospital
Recruiting

Study of AHB-171 in Chronic Hepatitis B Participants

June 01, 2026

Conditions: Hepatitis B, Chronic
Interventions: Drug: AHB-171; Drug: Placebo matching [Investigational Product]; Drug: Nucleos(t)ide Analogue (NA)
Sponsors: AusperBio Therapeutics Inc.
Not yet recruiting

OPTIMIZE 5.5 - Optimizing Impella 5.5 Outcomes Through Advanced Data Science

June 01, 2026

Conditions: Cardiogenic Shock; Mechanical Circulatory Support; Cardiogenic Shock Post Myocardial Infarction
Interventions: Device: Micro-axial flow pump support
Sponsors: Medical University of Vienna
Recruiting

Neoadjuvant Dalpiciclib + AI → SHR-A1811 for HR+/HER2-Low Breast Cancer

June 01, 2026

Conditions: Breast Cancer; HR Positive/HER2 Low Breast Cancer
Interventions: Drug: Dalpiciclib 125mg; Drug: Aromatase Inhibitor; Drug: SHR-A1811
Sponsors: Tang-Du Hospital
Not yet recruiting

Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in U.S. Healthy Participants

June 01, 2026

Conditions: Healthy Male and Female Subjects
Interventions: Drug: Y-4 tablet; Drug: Pregabalin capsule; Drug: Riluzole tablet
Sponsors: Neurodawn Pharmaceutical Co., Ltd.
Not yet recruiting

RDW and RV-PA Coupling in Acute PE

June 01, 2026

Conditions: Pulmonary Embolism Acute
Interventions: Other: Echo-cardiography
Sponsors: Assiut University
Not yet recruiting

Improving Outcomes After AF Ablation in Obese Patients

June 01, 2026

Conditions: Atrial Fibrillation (AF); Obesity (Disorder)
Interventions: Behavioral: Cardiac Rehabilitation and Lifestyle Modification; Behavioral: Usual Care
Sponsors: National Taiwan University Hospital
Recruiting

A Home-Based Exercise Intervention (CAREFit-BMT) in Improving Heart Function Among Patients With High Risk Acute Myeloid Leukemia Undergoing Stem Cell Transplant

June 01, 2026

Conditions: Acute Myeloid Leukemia
Interventions: Other: Aerobic Exercise; Other: Resistance Training; Procedure: Biospecimen Collection; Other: Electronic Health Record Review; Other: Survey Administration; Other: Interview
Sponsors: University of Washington; National Center for Advancing Translational Sciences (NCATS)
Not yet recruiting

Impact of Continuous Isotonic Saline Nebulisation Combined With Heated Humidification on the Rheology of Bronchial Secretions.

June 01, 2026

Conditions: Excessive Airway Secretions
Interventions: Device: Saline Nebulization; Device: Heated humidification
Sponsors: Cliniques universitaires Saint-Luc- Université Catholique de Louvain; Fisher and Paykel Healthcare; Aerogen
Not yet recruiting

Radial Access Data in Vascular Interventions Registry

June 01, 2026

Conditions: Radial Artery Occlusion; Radial Artery Spasm; Vascular Access Complications; Coronary Artery Disease; Peripheral Arterial Disease
Interventions: Procedure: Radial and Ulnar Artery Access
Sponsors: Mersin Medicalpark Hastanesi
Recruiting

Acute Heart Failure Registry

June 01, 2026

Conditions: Acute Heart Failure (AHF)
Sponsors: Jin Joo Park
Recruiting

Intravascular Ultrasound guidaNce versuS angIoGrapHy Guidance in Patients With ST-segment Elevation Myocardial Infarction

May 29, 2026

Conditions: STEMI; PCI
Interventions: Procedure: Intravascular Ultrasound; Procedure: Coronary angiography guidance
Sponsors: Shanghai Zhongshan Hospital; Shanghai 10th People's Hospital
Not yet recruiting

TRanscatheter Aortic-Valve Implantation Without On-site Cardiac Surgery

May 29, 2026

Conditions: Aortic Stenosis
Interventions: Procedure: Transcatheter Aortic Valve Implantation
Sponsors: University Hospital of Ferrara; Consorzio Futuro in Ricerca
Recruiting

The Return of Cardiovascular Information Trial (RECITE)

May 29, 2026

Conditions: Health Curiosity; Cardiovascular Health Risk Communication
Interventions: Behavioral: Coarse health result information presentation; Behavioral: Granular health risk information presentation
Sponsors: University of Texas Southwestern Medical Center
Not yet recruiting

Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

May 29, 2026

Conditions: Critical Illness; Pediatric Critical Illness; Respiratory Failure; Traumatic Brain Injury; Cardiac Arrest
Interventions: Device: Transcranial Doppler
Sponsors: University of Wisconsin, Madison
Not yet recruiting

An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function

May 29, 2026

Conditions: Congenital Heart Diseases; Cardiac Diseases
Sponsors: Matthias Stuber; Mayo Clinic; University of California, Los Angeles
Not yet recruiting

Optimal PEEP for Postoperative Oxygenation and Lung Aeration (ULTRASVENT-2)

May 29, 2026

Conditions: Postoperative Complications; Respiratory Insufficiency; Pulmonary Atelectasis; Positive-End Expiratory Pressure; Hypoxemia
Interventions: Procedure: Intraoperative Positive End-Expiratory Pressure (PEEP) Regulation
Sponsors: Moscow Multidisciplinary Clinical Center "Kommunarka"
Not yet recruiting

Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

May 29, 2026

Conditions: Post-stroke; Parkinson Disease; Amyotrophic Lateral Sclerosis; Mild Cognitive Impairment (MCI); Multiple Sclerosis; Frailty at Older Adults
Interventions: Device: Dual-task training with Virtual Reality; Device: Cycling training
Sponsors: Marta Mondellini; Istituti Clinici Scientifici Maugeri SpA; Villa Beretta Rehabilitation Center; University of Pisa
Not yet recruiting

Digital Engagement for Lifelong Health

May 29, 2026

Conditions: Life Style, Healthy; Risk Reduction; Health Promotion
Interventions: Other: DELPHI Personalized Digital Prevention Platform; Other: Passive Digital Monitoring Control
Sponsors: Istituto per la Ricerca e l'Innovazione Biomedica; Fondazione Don Carlo Gnocchi Onlus; Universita degli Studi di Palermo; Medilink s.r.l.
Recruiting

Pulmonary Artery Catheters in Cardiac Surgery

May 29, 2026

Conditions: Cardiac Surgery
Interventions: Device: Pulmonary Artery Catheter; Device: No Pulmonary Artery Catheter (No-PAC)
Sponsors: Monash University; Medical Research Future Fund; National Heart Foundation, Australia
Not yet recruiting

A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

May 29, 2026

Conditions: Atherosclerosis; Cardiovascular Diseases; Lipoprotein(a)
Interventions: Drug: Lepodisiran; Drug: Placebo
Sponsors: Eli Lilly and Company
Not yet recruiting

Structured Combined Exercise Program in Postmenopausal Women: Effects on Heart Rate Variability and Menopausal Symptoms

May 29, 2026

Conditions: Postmenopausal; Menopausal Symptoms; Autonomic Nervous System Diseases; Sleep Wake Disorders
Interventions: Behavioral: Structured Combined Exercise Program
Sponsors: Fenerbahce University
Recruiting

To Study and Explore the Predictive Effect of Insulin Resistance-related Indicators on In-stent Restenosis After Coronary Stent Implantation

May 29, 2026

Conditions: Coronary Artery Disease; In-stent Restenosis
Interventions: Other: Observational studies do not design intervention measures
Sponsors: Qilu Hospital of Shandong University
Completed

Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot Study

May 29, 2026

Conditions: Post-Traumatic Stress Disorder
Interventions: Device: Continuous wearable physiological monitoring (EmbracePlus, Empatica); Drug: Ketamine-assisted therapy (independently arranged); Other: Structured pre- and post-session interviews
Sponsors: Adriaan Dirk van der Wart
Not yet recruiting

CAPER-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS

May 29, 2026

Conditions: Coronary; Coronary Artery Disease
Interventions: Drug: Evolocumab; Diagnostic Test: Serial photon-counting coronary computed tomography angiography; Drug: Standard Lipid-Lowering Therapy
Sponsors: West China Hospital
Recruiting

Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment

May 29, 2026

Conditions: Atherosclerotic Cardiovascular Disease (ASCVD)
Interventions: Drug: Lipid-lowering therapy targeting LDL-C Sponsors: Beijing Anzhen Hospital
Not yet recruiting

Evaluation of Cardiac Autonomic Neuropathy in Children and Adolescents With Type 1 Diabetes Mellitus

May 29, 2026

Conditions: Cardiac Autonomic Neuropathy; Diabete Type 1; Pediatrics
Interventions: Device: Holter
Sponsors: Marwa Abouelela Abd Elsalam; Tanta University
Active, not recruiting

Establishment of Disease Characteristics and a Chinese Medicine Prognosis Risk Model Based on a Large-Scale Database After Coronary Revascularization

May 29, 2026

Conditions: Coronary Artery Disease; Postoperative Period; Myocardial Revascularization
Sponsors: Liu Qiang
Not yet recruiting

Clonal Hematopoiesis of Indeterminate Potential and Infarct Severity in ST-Elevation Myocardial Infarction

May 29, 2026

Conditions: ST-elevation Myocardial Infarction (STEMI); Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Interventions: Diagnostic Test: Clonal hematopoiesis assessment and cardiac magnetic resonance imaging
Sponsors: Medical University Innsbruck
Not yet recruiting

Cerebral Microembolization During Transcatheter Aortic Valve Implantation: Comparing Balloon-expandable and Self-expanding Valves

May 29, 2026

Conditions: Aortic Stenosis
Interventions: Device: Balloon-expandable transcatheter aortic valve; Device: Self-expanding transcatheter aortic valve
Sponsors: Ivan Zeljkovic; University Hospital Dubrava; Sisters of Mercy University Hospital
Not yet recruiting

A Comparison of a Medication Adherence Platform (FORTISKAP™) vs. Usual Care in Subjects on Oral Medications for the Treatment of Interstitial Lung Disease, Sarcoid and Pulmonary Hypertension

May 29, 2026

Conditions: Idiopathic Pulmonary Fibrosis (IPF); Sarcoidosis Lung; Pulmonary Hypertension; Usual Interstitial Pneumonia
Sponsors: Cosmos Rx, Inc; National Heart, Lung, and Blood Institute (NHLBI); Sentara Norfolk General Hospital
Not yet recruiting

A Study to Test the Safety and Blood Levels of PMG1016 in Healthy Adults

May 29, 2026

Conditions: Chronic Kidney Disease
Interventions: Drug: PMG1016 Dose 1; Drug: PMG1016 Dose 2; Drug: PMG1016 Dose 3; Drug: PMG1016 Dose 4
Sponsors: Pulmongene Ltd.
Not yet recruiting

Effect of Stress Ball Use on Pain, Anxiety, and Vital Signs During Ultrasound-Guided Tru-cut Biopsy

May 29, 2026

Conditions: Procedural Pain; Anxiety; Tru-Cut Biopsy; Stress Response
Interventions: Behavioral: Behavioral: Stress Ball Application
Sponsors: Istanbul University; Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Completed

Electrophysiological Biomarkers in Accelerated TMS for Depression

May 29, 2026

Conditions: Major Depressive Disorder (MDD)
Interventions: Device: Accelerated bilateral dmPFC-iTBS
Sponsors: Istanbul University - Cerrahpasa
Completed

SGLT2 Inhibitors on Coronary Atherosclerosis Progression Via Perivascular Adipose Tissue in Diabetes

May 29, 2026

Conditions: Type 2 Diabetes Mellitus (T2DM); Coronary Artery Disease; Atherosclerosis
Interventions: Drug: Dapagliflozin (DAPA); Other: Standard Care (Treatment as Usual)
Sponsors: Junjie Yang
Recruiting

A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting

May 29, 2026

Conditions: Diabetes Mellitus, Type 2; Diabetes Melletus; Glucose Metabolism Disorders; Metabolic Disorders; Nutritional and Metabolic Diseases; Endocrine System Diseases; Feeding Behavior; Behavior; Fasting; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptide Receptors; Receptors, G-Protein-Coupled; Receptors, Cell Surface; Membrane Proteins; Proteins; Receptors, Peptide
Interventions: Drug: Orforglipron
Sponsors: Eli Lilly and Company
Not yet recruiting

Uppsala Self-Screening of Cardiovascular Health (U-SCREEN)

May 29, 2026

Conditions: Cardiovascular Diseases; Hypertension; Dyslipidemias; Diabetes Mellitus; Atrial Fibrillation; Chronic Kidney Disease
Interventions: Behavioral: Home-based multimodal cardiovascular screening
Sponsors: Johan Sundström; Region of Uppsala
Recruiting

Effects of Resistance Training on Women With Functional Hypothalamic Amenorrhea

May 29, 2026

Conditions: Amenorrhea; Functional Hypothalamic Amenorrhea (FHA); Low Energy Availability; Relative Energy Deficiency in Sport
Interventions: Other: Resistance Training Program
Sponsors: Catholic University of Murcia
Not yet recruiting

Effects of Repletion of Sodium Chloride on Natriuresis, Blood Pressure, and Neurohormonal Activity in Patients With Chronic Heart Failure With Reduced Ejection Fraction

May 29, 2026

Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: Dietary Supplement: Sodium chloride supplementation; Dietary Supplement: Placebo administration
Sponsors: Wroclaw Medical University
Not yet recruiting

A Phase 3 Study of Extended-release Tacrolimus in Subjects With Pulmonary Arterial Hypertension and Functional Limitations

May 29, 2026

Conditions: Pulmonary Arterial Hypertension; Pulmonary Arterial Hypertension (PAH); Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH); Pulmonary Arterial Hypertension PAH; Pulmonary Arterial Hypertension WHO Group I
Interventions: Drug: VI-0106; Drug: Placebo
Sponsors: VIVUS LLC
Not yet recruiting

Impact of Hyperemic State on Angio-IMR Performance

May 29, 2026

Conditions: Coronary Artery Disease; Microvascular Coronary Artery Disease
Interventions: Diagnostic Test: Angiography-derived IMR
Sponsors: Shanghai Zhongshan Hospital; First Affiliated Hospital, Sun Yat-Sen University; Zhongnan Hospital; The 7th People's Hospital of Zhengzhou
Recruiting

Evaluation of Cardiovascular Risks Among the Participants of the ESC Congress 2025

May 29, 2026

Conditions: Cardiovascular Risk
Interventions: Behavioral: Questionnaire and Physical Exam; Biological: blood draw; Behavioral: Questionnaire and Physical Exam; Procedure: auscultation
Sponsors: European Society of Cardiology
Completed

Isoinertial Training in Patients With COPD

May 29, 2026

Conditions: COPD (Chronic Obstructive Pulmonary Disease)
Interventions: Device: Isoinertial training; Other: Traditional rehabilitation (control group)
Sponsors: Universidad Manuela Beltrán
Recruiting

Efficacy of Early Rhythm Control in AF With TR Patients

May 29, 2026

Conditions: Atrial Fibrillation (AF); Tricuspid Regurgitation (TR)
Interventions: Drug: Anti-arrhythmic drugs for rhythm control; Procedure: DC cardioversion, catheter ablation for rhythm control; Other: Usual care
Sponsors: Samsung Medical Center
Recruiting

Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves

May 29, 2026

Conditions: Heart Failure; Heart Valve Prosthesis
Interventions: Drug: semaglutide; Drug: Dapagliflozin (10mg Tab)
Sponsors: Kafrelsheikh University
Completed

Multidimensional Sleep Health Intervention for Couples

May 29, 2026

Conditions: Blood Pressure; Sleep; Cardiovascular Health
Interventions: Behavioral: Multidimensional Sleep Health Promotion Intervention
Sponsors: Columbia University
Not yet recruiting

Optimal Shock Energy for Electrical Cardioversion of Atrial Fibrillation

May 28, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Procedure: Direct current biphasic electrical cardioversion; Diagnostic Test: blood sampling
Sponsors: Motol and Homolka University Hospital
Not yet recruiting

Construction of a Cohort of Elderly Patients With Atrial Fibrillation in Rural China

May 28, 2026

Conditions: Atrial Fibrillation (AF); Heart Failure; Screening; Progression
Sponsors: Jiangsu Taizhou People's Hospital
Recruiting

Use and Costs of P2Y12 Inhibitors After Acute Myocardial Infarction

May 28, 2026

Conditions: Acute Myocardial Infarction (AMI)
Interventions: Drug: Clopidogrel; Drug: Prasugrel; Drug: Ticagrelor
Sponsors: Brigham and Women's Hospital
Active, not recruiting

Osteoporosis and Sarcopenia Prevention in Middle-Aged Population

May 28, 2026

Conditions: Osteoporosis; Sarcopenia
Interventions: Behavioral: Intervention Group; Behavioral: Control Group
Sponsors: The University of Hong Kong; The Hong Kong Jockey Club Charities Trust; The Family Planning Association of Hong Kong
Not yet recruiting

Percepta for Cognitive Optimization

May 28, 2026

Conditions: Mild Cognitive Impairment (MCI); Memory
Interventions: Dietary Supplement: Percepta; Dietary Supplement: Placebo
Sponsors: Cerebrum DAO Association; Reputable Health
Not yet recruiting

Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on Tissue-resident Regulatory T Cells

May 28, 2026

Conditions: Coronary Artery Disease; Myocardial Infarction (MI); CABG
Interventions: Drug: Interleukin-2 (Aldesleukin); Procedure: Standard care; Drug: Interleukin-2 (Aldesleukin)
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Royal Papworth Hospital
Recruiting

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

May 28, 2026

Conditions: Liver Fibrosis; Hepatic Cirrhosis
Interventions: Drug: AZD2389; Other: Placebo
Sponsors: AstraZeneca
Recruiting

Foot Reflexology and Massage in Neonates Receiving Phototherapy

May 28, 2026

Conditions: Neonatal Hyperbilirubinemia
Interventions: Behavioral: Foot Reflexology; Behavioral: Body Massage; Device: Phototherapy Device
Sponsors: Aydin Adnan Menderes University
Not yet recruiting

Clinical Efficacy and Population Pharmacokinetics of β-lactams in Cirrhotic Patients

May 28, 2026

Conditions: Bacterial Infections
Interventions: Drug: β-lactams
Sponsors: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recruiting

MitrAl Valve Calcium aSsEssmEnt With TrueVue Trans-illumination 3D Rendering.

May 28, 2026

Conditions: Mitral Annular Calcification; Mitral Valve Disease
Sponsors: Centro Cardiologico Monzino
Recruiting

AI-Based Risk Prediction Model for Upper Digestive Tract Cancer

May 28, 2026

Conditions: Gastric Cancer (GC); Premalignant Lesion; Gastric Intestinal Metaplasia; Atrophic Gastritis; Dysplasia Stomach; Esophageal Cancer (EsC)
Sponsors: National Taiwan University Hospital
Not yet recruiting

Effect of Positioning and ACBT on Pulmonary Complications After Cardiac Surgery

May 28, 2026

Conditions: Postoperative Pulmonary Complications (PPCs); Cardiac Surgery With Sternotomy; Atelectasis; Postoperative Pneumonia
Interventions: Behavioral: Structured Position Management Protocol; Behavioral: Active Cycle of Breathing Techniques (ACBT)
Sponsors: Assiut University
Not yet recruiting

Predictors of Transmural Non-Occlusive Mesenteric Ischemia in ICU Patients With Suspected Acute Mesenteric Ischemia

May 28, 2026

Conditions: Non-Occlusive Mesenteric Ischaemia (NOMI); Acute Mesenteric Ischemia
Interventions: Other: Observation
Sponsors: University of Tartu
Recruiting

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

May 28, 2026

Conditions: Depression; Parkinson's Disease (PD)
Interventions: Drug: Psilocybin (drug); Drug: Psilocybin (drug)
Sponsors: Yale University; Michael J. Fox Foundation for Parkinson's Research
Not yet recruiting

Identifying Essential Elements of SAP Supports

May 28, 2026

Conditions: Rheumatic Heart Disease in Children; Heart Disease, Valvular
Interventions: Behavioral: Case Management Supports
Sponsors: Children's Hospital Medical Center, Cincinnati; Uganda Heart Institute
Completed

Optimal Targeted High-definition Transcranial Direct Current Stimulation for Reducing Post-stroke Upper Limb Motor Impairments

May 28, 2026

Conditions: Hemiparetic Stroke
Interventions: Device: High-definition transcranial direct stimulation: sham; Device: High-definition transcranial direct stimulation: optimal; Behavioral: Modified constraint-induced movement therapy
Sponsors: Carle Foundation Hospital; American Heart Association
Not yet recruiting

Pulsed Field Ablation Outcomes With Efficacy and Randomization in Atrial Fibrillation (POWER-AF)

May 28, 2026

Conditions: Atrial Fibrillation (AF); Atrial Fibrillation Ablation; Atrial Fibrillation Recurrent; Pulsed Field Ablation; Radiofrequency Catheter Ablation
Interventions: Procedure: Pulsed field ablation; Procedure: Radiofrequency ablation alone; Device: Pulsed field ablation system
Sponsors: China National Center for Cardiovascular Diseases
Recruiting

REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices

May 28, 2026

Conditions: Heart Failure; Advanced Heart Failure; Left Ventricular Assist Device; LVAD; Cardiac Rehabilitation; Telemedicine; Remote Exercise; Ventricular Assist Device; Exercise Training; Conditioning Therapy; Cardiopulmonary Exercise Test; Six Minute Walk Test; Quality of Life; Telerehabilitation
Interventions: Other: Remote Physical Conditioning Program (Telerehabilitation); Other: Usual care. No Remote Monitoring.
Sponsors: Puerta de Hierro University Hospital; Carlos III Health Institute
Not yet recruiting

High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study

May 28, 2026

Conditions: Pyruvate Kinase Deficiency; Glucose 6 Phosphate Dehydrogenase Deficiency
Interventions: Drug: Vitamin C
Sponsors: University of Utah
Not yet recruiting

Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes

May 28, 2026

Conditions: PARKINSON DISEASE (Disorder); Atypical Parkinsonism; Multiple System Atrophy; Progressive Supranuclear Palsy (PSP); Dementia With Lewy Bodies (DLB)
Sponsors: International Institute of Molecular and Cell Biology in Warsaw; Medical University of Warsaw; Medical Centre for Postgraduate Education
Not yet recruiting

Baduanjin Intervention in Clinical Studies After Coronary Revascularization Surgery

May 27, 2026

Conditions: Percutaneous Coronary Intervention; Myocardial Revascularization; Coronary Artery Disease
Interventions: Behavioral: Standardized Western medical treatment + Standardized Baduanjin rehabilitation training; Behavioral: Standardized Western medical treatment + Aerobic exercise training
Sponsors: Liu Qiang; The Third Affiliated hospital of Zhejiang Chinese Medical University; Zhejiang Provincial People's Hospital; The First Affiliated Hospital of Zhejiang Chinese Medical University
Not yet recruiting

Effect of Hot Spring Therapy on Autonomic Nervous System and Exercise Performance During Altitude Training

May 27, 2026

Conditions: Altitude Training Adaptation; Autonomic Nervous System; Hydrotherapy; Exercise Performance; Altitude Sickness
Interventions: Behavioral: Control Group：Natural Recovery; Behavioral: Hot water immersion group; Behavioral: hot spring immersion group
Sponsors: Macao Polytechnic University
Recruiting

Clinical Information System Impact on Hospitalized Patients With Chronic Disease

May 27, 2026

Conditions: Diabete Mellitus; Kidney Disease; Heart Failure; Coronary Artery Disease; Chronic Lung Diseases
Interventions: Other: Clinical Information System (CIS) / Connect Care Implementation
Sponsors: University of Calgary
Not yet recruiting

Mitigation of Health Effects in Pregnant Women by Reducing Exposure to Heat and Air Pollution

May 27, 2026

Conditions: Sleep Quality
Interventions: Other: Heat intervention; Other: Heat and air pollution mitigation intervention
Sponsors: University of Cyprus; Azienda ospedaliera Garibaldi Catania; University of Catania
Recruiting

Heparin to Prevent Organ Failure in Acute Pancreatitis

May 27, 2026

Conditions: Acute Pancreatitis (AP)
Interventions: Drug: Unfractionated heparin; Other: Standard supportive care
Sponsors: Allied Hospital Faisalabad
Not yet recruiting

Pediatric Solid Organ Transplant Patient Engagement Using an Educational Tablet-Based Game(Mystic Wizard)

May 27, 2026

Conditions: Solid Organ Transplant
Interventions: Behavioral: Mystic Wizard
Sponsors: Stanford University
Not yet recruiting

Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients

May 27, 2026

Conditions: Hemodyalysis
Interventions: Diagnostic Test: Transthoracic ultrasound at rest; Diagnostic Test: Cardiological stress test; Diagnostic Test: Coronary angiography
Sponsors: Centre Hospitalier Departemental Vendee
Not yet recruiting

Effects of Exercise Snacks on Clinical and Health Outcomes

May 27, 2026

Conditions: Prediabetes / Type 2 Diabetes; Sedentary Behaviors; Physical Inactivity
Interventions: Behavioral: Exercise Snacks
Sponsors: Chimei Medical Center
Not yet recruiting

Cerebral Microembolization During Pulmonary Vein Isolation: Comparison of Different Pulsed Field Ablation Systems

May 27, 2026

Conditions: Ablation of Arrhythmia's
Interventions: Device: Pulsed field ablation using PulseSelect system; Device: Pulsed field ablation using Varipulse system; Device: Pulsed field ablation using Farapulse system; Device: Pulsed field ablation using Sphere-9 system; Device: Pulsed field ablation using Sphere-360 system
Sponsors: Ivan Zeljkovic; University Hospital Dubrava; University Hospital Center Sisters of Charity, Zagreb, Croatia
Not yet recruiting

Oral Anticoagulation After Stroke With Prior ICH in Subjects With AF

May 27, 2026

Conditions: Acute Ischemic Stroke; Intracerebral Hemorrhage; Atrial Fibrillation (AF)
Interventions: Drug: Direct Oral Anticoagulants (DOACs); Drug: Antiplatelet Therapy or No Antithrombotic Therapy
Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting

Validation of the Italian SCHFI v.8 and the CC-SCHFI v.3

May 27, 2026

Conditions: Heart Failure
Interventions: Diagnostic Test: Administration of the Italian version of the SCHFI and the CC-SCHFI, plus other self-reported ouctome measures
Sponsors: Centro Cardiologico Monzino; University of Rome Tor Vergata; IRCCS Policlinico S. Donato; A.O. Ospedale Papa Giovanni XXIII; IRCCS Multimedica; Federico II University; Azienda Ospedaliera Universitaria Renato Dulbecco; Azienda Ospedaliera Universitaria Policlinico "G. Martino"; IRCCS Centro Neurolesi Bonino Pulejo
Not yet recruiting

MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery

May 27, 2026

Conditions: Colorectal Cancer; Intraoperative Hemodynamic Management
Interventions: Procedure: Mean Arterial Pressure-Guided Hemodynamic Management; Procedure: Cardiac Index-Guided Hemodynamic Management
Sponsors: Ankara Etlik City Hospital
Not yet recruiting

Azithromycin to Modify Bronchiectasis Exacerbation Risk

May 27, 2026

Conditions: Non-cystic Fibrosis Bronchiectasis; Bronchiectasis Adult; Bronchiectasis; Bronchiectasis With Acute Exacerbation
Interventions: Other: Standard Bronchiectasis Care; Drug: Azithromycin; Drug: Matching Placebo
Sponsors: Assiut University
Not yet recruiting

64Cu-DOTA A2 scFv-Fc2 DM With Positron Emission Tomography for the Imaging of Patients With Locally Advanced or Metastatic PSCA-Expressing Pancreatic Cancer

May 27, 2026

Conditions: Locally Advanced Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8
Interventions: Procedure: Biospecimen Collection; Drug: Copper Cu 64-DOTA-A2DM; Procedure: Positron Emission Tomography; Other: Radioconjugate
Sponsors: City of Hope Medical Center; National Cancer Institute (NCI)
Not yet recruiting

Duchenne Electronic Health Record Study

May 27, 2026

Conditions: Duchenne Muscular Dystrophy (DMD); Becker Muscular Dystrophy; Dystrophinopathy; Dystrophinopathy Symptomatic Female Carrier
Interventions: Other: Observational study with patients who may be treated with various disease-modifying therapies
Sponsors: The Duchenne Registry; Parent Project Muscular Dystrophy
Recruiting

Using Bilateral Stimulation (A Pre-existing Trauma Technique) After Eating to Reduce Anxiety in People Recovering From Eating Disorders

May 27, 2026

Conditions: Eating Disorders; Eating Disorders Symptoms
Interventions: Behavioral: Bilateral Stimulation
Sponsors: San Francisco State University
Completed

The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury

May 27, 2026

Conditions: Acute Kidney Injury (AKI)
Sponsors: Zhongda Hospital; Nanjing First Hospital, Nanjing Medical University; The First Affiliated Hospital of Anhui Medical University
Not yet recruiting

Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection

May 27, 2026

Conditions: Rheumatic Heart Disease
Interventions: Diagnostic Test: AI assisted echocardiography
Sponsors: Children's Hospital Medical Center, Cincinnati; Uganda Heart Institute; Ochsner Health System; Vanderbilt University Medical Center; Children's National Health Center
Not yet recruiting

Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers

May 26, 2026

Conditions: Heart Failure; Hypertension; Kidney Failure
Interventions: Other: Infusion of two different cardiac peptides plus vehicle
Sponsors: Peter Fruergaard Andersen; Region Hovedstadens Apotek; Rigshospitalet, Denmark; University Hospital Bispebjerg and Frederiksberg
Completed

Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda

May 26, 2026

Conditions: Rheumatic Heart Disease
Interventions: Other: The ACT+ Strategy
Sponsors: Children's Hospital Medical Center, Cincinnati; Uganda Heart Institute
Not yet recruiting

Factors of Potentially Dangerous Drug Interactions in Patients With Cardiovascular Diseases and Multimorbidity

May 26, 2026

Conditions: Cardiovascular Diseases, Multimorbidity, Drug Interactions
Sponsors: National Medical Research Center for Therapy and Preventive Medicine; Alloro LLC, Fryazino, Moscow Region, Russia
Active, not recruiting

RAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)

May 26, 2026

Conditions: Chronic Kidney Disease; Type 2 Diabetes
Interventions: Other: Epic-Based Clinician Notification; Other: Usual Care
Sponsors: Baylor Research Institute
Not yet recruiting

Mitigation of Health Effects in Older Adults With Hypertension by Reducing Exposure to Heat and Air Pollution

May 26, 2026

Conditions: Hypertension Arterial; 65 Years Older
Interventions: Behavioral: Heat intervention; Behavioral: Heat and air pollution mitigation intervention
Sponsors: University of Cyprus; FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA; PANCYPRIAN FEDERATION OF LABOUR
Recruiting

Fast Cardiac Bone SPECT-CZT in Transthyretin Cardiac Amyloidosis

May 26, 2026

Conditions: Cardiac Amyloidosis
Interventions: Other: bone scintigraphy
Sponsors: Central Hospital, Nancy, France
Not yet recruiting

Validation of ECG-Based Ventricular Arrhythmia Localization Algorithms in Patients With Repaired Tetralogy of Fallot

May 26, 2026

Conditions: Tetralogy of Fallot (TOF); Ventricular Tachycardia
Interventions: Diagnostic Test: RV and LV pace mapping
Sponsors: Boston Children's Hospital
Not yet recruiting

Development of a Cardiac Signal Analysis Algorithm for Bladder Filling Assessment: Pilot Study

May 26, 2026

Conditions: Urinary Incontinence
Sponsors: University Hospital, Lille
Completed

Cardiometabolic Effects of Low-Fat and Full-Fat Dairy

May 26, 2026

Conditions: Cardiovascular (CV) Risk
Interventions: Other: Full-fat dairy; Other: Low-fat dairy
Sponsors: Penn State University
Not yet recruiting

TAVI in LOW RISK in the REAL WORLD

May 26, 2026

Conditions: Aortic Valve Stenosis
Sponsors: Centro Cardiologico Monzino; Fondazione Poliambulanza Istituto Ospedaliero
Completed

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

May 26, 2026

Conditions: Degenerative Mitral Valve Disease
Sponsors: Cedars-Sinai Medical Center; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women

May 26, 2026

Conditions: Pregnancy; Pregnancy - Prenatal Testing; Hypertension (HTN)
Interventions: Behavioral: Isometric Handgrip Exercise; Behavioral: Control Rest
Sponsors: University of Poitiers; Poitiers University Hospital; Laboratory MOVE, Faculty of Sport Sciences, University of Poitiers, France
Recruiting

Community Support and Mobile Apps to Help Black Women Control High Blood Pressure After Pregnancy

May 26, 2026

Conditions: Hypertensive Disorders of Pregnancy (HDP); Hypertension, Pregnancy Induced; Severe Maternal Morbidity; Postpartum Hypertension
Interventions: Other: Collaborative care; Other: Standard of Care (SOC)
Sponsors: University of Nebraska
Not yet recruiting

Psychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest Alerts

May 26, 2026

Conditions: Mental Health; Stress Disorder, Post Traumatic
Interventions: Behavioral: Structured Debriefing
Sponsors: University Hospital, Aachen; Alexianer Center for Mental Health Care, Aachen; Aachen Institute for Rescue Management and Public Safety (ARS), RWTH Aachen University
Not yet recruiting

Acupuncture for Heel Pain Syndrome: A Multicenter Randomized Controlled Trial

May 26, 2026

Conditions: Heel Pain Syndrome
Interventions: Procedure: Acupuncture; Procedure: Manual Therapy; Other: Sham Acupuncture
Sponsors: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Not yet recruiting

Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans

May 26, 2026

Conditions: Salt Sensitivity of Blood Pressure; High Blood Pressure; Inflammation; Renin-Angiotensin-Aldosterone System
Interventions: Drug: 2-hydroxybenzylamine; Drug: Placebo
Sponsors: Vanderbilt University Medical Center
Not yet recruiting

Children With Surgically Corrected Acyanotic Congenital Heart Disease

May 26, 2026

Conditions: Acyanotic Congenital Heart Disease
Interventions: Other: treadmill walking sessions
Sponsors: Delta University for Science and Technology
Not yet recruiting

Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease

May 26, 2026

Conditions: Aortic Stenosis; Aortic Regurgitation; Mitral Regurgitation; Tricuspid Regurgitation
Interventions: Device: Transcatheter Aortic Valve Replacement; Device: Transcatheter Edge-to-Edge Repair; Device: Transcatheter Tricuspid Valve Annuloplasty; Device: Surgical Aortic Valve Replacement
Sponsors: Beijing Anzhen Hospital
Not yet recruiting

OCT-A Biomarkers for Cognitive Impairment in Patients With Chronic Atrial Fibrillation

May 26, 2026

Conditions: OCT Angiography; Atrial Fibrillation (AF); Mild Cognitive Impairment
Interventions: Diagnostic Test: OCT-angiography
Sponsors: Universitair Ziekenhuis Brussel
Active, not recruiting

An Open-label Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)

May 26, 2026

Conditions: LMNA-Related Dilated Cardiomyopathy
Interventions: Genetic: NVC-001 - Low Dose; Genetic: NVC-001 - Intermediate Dose; Genetic: NVC-001 - High Dose
Sponsors: Nuevocor Pte. Ltd.
Not yet recruiting

Utility of Whole Genome Sequencing in Fetuses With Abnormal Ultrasound Findings

May 26, 2026

Conditions: Prenatal Diagnosis; Fetal Diseases
Sponsors: Women's Hospital School Of Medicine Zhejiang University
Recruiting

Real-Time and Retrospective Emotion Awareness With Cognitive Reappraisal Training

May 26, 2026

Conditions: Anxiety Symptoms; Depressive Symptoms; Emotion Regulation
Interventions: Behavioral: Wearable-Based Real-Time Emotional Awareness and Cognitive Reappraisal Training; Behavioral: Retrospective Emotion Journaling and Cognitive Reappraisal Training
Sponsors: Asia University
Completed

Edaravone Dexborneol for Post-Stroke Epilepsy

May 22, 2026

Conditions: Post-stroke Epilepsy; Post-stroke Seizure
Interventions: Drug: Treatment of edaravone dexborneol sublingual tablets containin edaravone 30 mg plus borneol 6 mg, twice daily (with an interval of ≥6 hours between doses) for three months.; Drug: Placebo
Sponsors: First Affiliated Hospital of Wenzhou Medical University; The Third Affiliated Hospital of Wenzhou Medical University; Ningbo Medical Center Lihuili Hospital; The Central Hospital of Lishui City; Ningbo No.2 Hospital
Not yet recruiting

A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)

May 22, 2026

Conditions: Sarcoma
Interventions: Biological: Ris-Rez; Biological: G-CSF
Sponsors: GlaxoSmithKline
Not yet recruiting

Multi-organ Imaging of Microvascular and Metabolic Function

May 22, 2026

Conditions: Healthy Subjects (HS); Cardiovascular Diseases (CVD)
Interventions: Drug: 18F-FDG; Device: Positron Emission Tomography (PET)
Sponsors: Massachusetts General Hospital
Not yet recruiting

Comparison of Sucking in Premature Infants and Infants With Pierre Robin Sequence

May 22, 2026

Conditions: Premature Infants; Pierre Robin Sequence; Feeding Disorder
Interventions: Other: Succiometry
Sponsors: Hospices Civils de Lyon
Completed

Analysis of Growth Differentiation Factor 15 (GDF-15), Mid Regional proAdrenomedullin (MR proADM), and Persepsin Levels in Patient in Acute Coronary Syndrome Patients With Pneumonia, With or Without Influenza Vaccination

May 22, 2026

Conditions: Acute Coronary Syndromes (ACS); Pneumonia; COPD (Chronic Obstructive Pulmonary Disease)
Interventions: Drug: Vaxigrip; Drug: antibiotic treatments; Procedure: percutaneus coronary intervention
Sponsors: University of Brawijaya
Recruiting

Investigating a Personalized Approach to Anti-Platelet Therapy

May 22, 2026

Conditions: High Risk Bleeding
Interventions: Drug: Genotyping guided therapy for anti-platelet management
Sponsors: Ottawa Heart Institute Research Corporation
Not yet recruiting

Body Composition, Functional Capacity, and Respiratory Muscle Endurance in Obesity With Restrictive Ventilatory Pattern

May 22, 2026

Conditions: Obesity
Interventions: Other: Pulmonary Function, Body Composition, and Functional Capacity Assessment
Sponsors: Biruni University
Not yet recruiting

Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE

May 22, 2026

Conditions: Multivessel Coronary Artery Disease; Hypertension Resistant to Conventional Therapy
Interventions: Device: Renal denervation
Sponsors: Ceric Sàrl
Not yet recruiting

AR Health Education Video for Postoperative Breast Cancer Patients

May 22, 2026

Conditions: Breast Cancer; Anxiety; Depression
Interventions: Behavioral: Augmented Reality Health Education Video; Behavioral: Routine Health Education
Sponsors: Tungs' Taichung Metroharbour Hospital
Recruiting

A Study of Risvutatug Rezetecan in Combination With Ivonescimab in Participants With Advanced Solid Tumors (EMBOLD PanTumour-103)

May 22, 2026

Conditions: Solid Tumors
Interventions: Biological: Ris-Rez; Biological: Ivonescimab
Sponsors: GlaxoSmithKline
Not yet recruiting

Music for Pain and Dementia

May 22, 2026

Conditions: Alzheimer Disease; Dementia; Mild Cognitive Impairment; Peer-bonded Caregiver; Caregiver
Interventions: Behavioral: Drumming session; Behavioral: Music-listening session
Sponsors: Yale University; Renée Fleming Foundation; Yale University School of Medicine, Department of Psychiatry; Howard University; NeuroArts Blueprint Initiative; National Center for Complementary and Integrative Health (NCCIH)
Recruiting

Safety and Feasibility of Transcatheter Injectable Hydrogel in Acute STEMI Reperfusion Injury (REFINE Study)

May 22, 2026

Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: Device: Injectable protein alginate-based hydrogel; Other: No additional intervention
Sponsors: Myomed Technology (Shaoxing) Co., Ltd.
Not yet recruiting

STRATEGY-PE: Real-World Treatment Strategies for Intermediate-High Risk Pulmonary Embolism

May 22, 2026

Conditions: Pulmonary Embolism; Venous Thromboembolism
Interventions: Drug: Anticoagulants; Drug: Thrombolytic Agents; Device: Mechanical Thrombectomy Devices
Sponsors: Nanjing First Hospital, Nanjing Medical University
Not yet recruiting

Analgesia for Perineal Surgeries in High-risk Pediatric Patients

May 22, 2026

Conditions: Analgesia
Interventions: Other: Systemic analgesia; Procedure: Sacral multifidus plane block
Sponsors: Zagazig University
Not yet recruiting

Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting

May 22, 2026

Conditions: Heart Failure; Coronary Arterial Disease
Sponsors: Samson Badalyan
Not yet recruiting

Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.

May 22, 2026

Conditions: Prediabetes / Type 2 Diabetes
Interventions: Diagnostic Test: Oral Fat Load Test
Sponsors: Angelina Passaro; University Hospital of Ferrara; S. Anna Hospital; Azienda USL Ferrara; Università degli Studi di Ferrara
Recruiting

Investigation of the Effects of Whole Body Vibration Application on Muscle Functional Level, Physical Fitness and Respiratory Parameters After Bariatric Surgery

May 22, 2026

Conditions: Obesity & Overweight; Morbid Obesity; Morbid Obesity Requiring Bariatric Surgery
Interventions: Other: Resistance Training; Other: Whole Body Vibration; Other: Control Group
Sponsors: Kirsehir Ahi Evran Universitesi; Istinye University
Not yet recruiting

Diagnostic Study of Structural Heart Disease Based on Cardiac Electromechanical Signals

May 22, 2026

Conditions: Valvular Heart Disease
Interventions: Diagnostic Test: Transthoracic Echocardiography
Sponsors: First Affiliated Hospital Xi'an Jiaotong University; Second Affiliated Hospital of Xi'an Jiaotong University
Not yet recruiting

Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)

May 22, 2026

Conditions: Cardiac Sarcoidosis; Sarcoidosis of the Heart; Sarcoidosis With Myocarditis; Sarcoidosis, Cardiac
Interventions: Other: Exosome Analysis
Sponsors: Mayo Clinic
Not yet recruiting

Assessment of Heart Rate Variability for Predicting Obstructive Sleep Apnea in Patients With Hypertension

May 22, 2026

Conditions: Obstructive Sleep Apnea; Hypertension
Interventions: Diagnostic Test: Polysomnography
Sponsors: Kaohsiung Armed Forces General Hospital
Recruiting

Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES Trial

May 22, 2026

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Behavioral: Avoidance; Procedure: Biospecimen Collection; Behavioral: Cigarette Smoking; Procedure: Eye Movement Measurement; Behavioral: Healthcare Activity; Other: Questionnaire Administration; Behavioral: Refrain from Smoking; Other: Vaping; Drug: Standardized E-Cigarette Nicotine Administration
Sponsors: Ohio State University Comprehensive Cancer Center
Not yet recruiting

Epicardial Fat Tissue and Cardiometabolic Risk in Russian and Asian Populations

May 22, 2026

Conditions: Epicardial Fat Tissue (EFT); Chronic Non-Communicable Diseases (NCDs); Visceral Obesity
Sponsors: National Medical Research Center for Therapy and Preventive Medicine
Recruiting

Radiomics Features Predicting Outcomes of PAD

May 22, 2026

Conditions: Peripheral Artery Disease (PAD)
Interventions: Other: Non interventional study
Sponsors: Zhijun Bao
Active, not recruiting

The Impact of Volume Overload on Obstructive Sleep Apnea in Patients With Congestive Heart Failure

May 22, 2026

Conditions: Heart Failure; Obstructive Sleep Apnea (OSA)
Sponsors: Itshak Amsalem
Recruiting

Dexmedetomidine vs Propofol-lidocaine Mixture in Preventing the Post Operative Emergence Agitation Following Sevoflurane Anasthesia

May 22, 2026

Conditions: Emergence Agitation
Interventions: Drug: Dexmedetomidine; Drug: Propofol; Drug: Placebo
Sponsors: Sohag University
Not yet recruiting

Efficacy and Safety of Qishen Yiqi Dropping Pills in Patients With Severe Pulmonary Hypertension

May 22, 2026

Conditions: Idiopathic Pulmonary Hypertension
Interventions: Drug: Qishen Yiqi Dropping Pills 0.5g Oral Three Times Daily + Targeted Therapy for Pulmonary Arterial Hypertension; Drug: Standard Pulmonary Arterial Hypertension (PAH)-Targeted Therapy Alone
Sponsors: Guangdong Provincial People's Hospital
Recruiting

Evaluation of Cardiovascular Risks Among the Participants of the EAPC Congress 2026

May 22, 2026

Conditions: Cardiovascular Risks
Interventions: Behavioral: Questionnaire and Physical Exam; Behavioral: Questionnaire and Physical Exam; Biological: blood draw
Sponsors: European Society of Cardiology
Completed

AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation

May 22, 2026

Conditions: Atrial Fibrillation (AF); Heart Failure; Cardiac Pacing
Interventions: Procedure: Conduction System Pacing; Procedure: Cardiac resynchronization therapy
Sponsors: University Medical Center Groningen
Not yet recruiting

Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery

May 22, 2026

Conditions: Unilateral Vocal Cord Paralysis; Unilateral Vocal Cord Paresis
Interventions: Other: Intraoperative laryngeal nerve monitor
Sponsors: University of Alberta
Not yet recruiting

Nature-based Outdoor Activities for Promoting Stress Resilience in Employees

May 22, 2026

Conditions: Stress (Psychology)
Interventions: Behavioral: Nature outdoor activities
Sponsors: The Chinese University of Hong Kong, Shenzhen
Completed

A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037)

May 22, 2026

Conditions: Pulmonary Arterial Hypertension
Interventions: Biological: Sotatercept; Drug: Background PAH Therapy
Sponsors: Merck Sharp & Dohme LLC
Not yet recruiting

Oxygen Delivery Index (ODIN) Study

May 22, 2026

Conditions: Heart Failure; Cardiogenic Shock
Interventions: Device: Oxygen Delivery Index (ODIN) Device
Sponsors: NYU Langone Health
Not yet recruiting

Integrating Smart Wearable Device Into Digital Insomnia Treatment Application: Exploration of Combining Emotional and Lifestyle Records

May 22, 2026

Conditions: Insomina; Mood Change
Interventions: Device: Personalized Experience Sampling Method; Device: Non-personalized Experience Sampling Method
Sponsors: National Taipei University of Technology
Enrolling by invitation

Pharmacy-based Opportunistic Atrial Fibrillation Screening Integrated With Emergency Services (NUMAPLUS-FA)

May 22, 2026

Conditions: Atrial Fibrillation (Prevention of Stroke); Arrythmia, Cardiac; Mass Screening; Pharmacies
Interventions: Other: Integrated pharmacy-based AF screening circuit
Sponsors: Centro de Emergencias Sanitarias 061 Andalucía; Andaluz Health Service; University of Seville; Real e Ilustre Colegio Oficial de Farmacéuticos de Sevilla; Andalusian School of Public Health; Andalusian Regional Ministry of Health
Not yet recruiting

A Clinical Study of HRS-7156 in Healthy Participants

May 22, 2026

Conditions: Heart Failure
Interventions: Drug: HRS-7156; Drug: HRS-7156 placebo
Sponsors: Shandong Suncadia Medicine Co., Ltd.
Not yet recruiting

Intraocular Pressure During Static Apnea

May 22, 2026

Conditions: Glaucoma; Intraocular Pressure; Apnea
Sponsors: University Hospital Olomouc; Palacky University; Lensi Turnov s.r.o.
Completed

The Role of CD34+ Stem Cells in the Pathogenesis of Takotsubo Syndrome

May 22, 2026

Conditions: Tako Tsubo Cardiomyopathy; Microvascular Dysfunction; CD34+ Stem Cells; Heart Failure; Cardiac Contractility Recovery
Sponsors: University Medical Centre Ljubljana
Recruiting

Tiprelestat Versus Placebo When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH)

May 22, 2026

Conditions: Pulmonary Arterial Hypertension (PAH)
Interventions: Drug: Tiprelestat (5 mg); Drug: Placebo (1 mL 0.9% saline solution); Drug: Tiprelestat (10 mg)
Sponsors: Stanford University; National Heart, Lung, and Blood Institute (NHLBI); University of Michigan
Not yet recruiting

Opioid-free Anesthesia and Postoperative Delirium

May 22, 2026

Conditions: Postoperative Delirium; Gastrointestinal Tumors
Interventions: Drug: OFA group; Drug: OBA group
Sponsors: Qianfoshan Hospital
Not yet recruiting

Short-Term Inspiratory Muscle Training and Aerobic Exercise in Women With COPD

May 22, 2026

Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Device: Inspiratory Muscle Training; Behavioral: Aerobic Exercise; Device: Placebo Inspiratory Muscle Training
Sponsors: Mehmet İsmail TOSUN
Completed

Gut Leakage' in Dengue

May 22, 2026

Conditions: Dengue; Dengue Hemorrhagic Fever; Intestinal Disease; Ascites; Dengue With Warning Signs; Gut Microbiome
Sponsors: University of Oxford
Not yet recruiting

A Well-Being Intervention for People With IBS

May 22, 2026

Conditions: Irritable Bowel Syndrome
Interventions: Behavioral: Well-Being Intervention
Sponsors: University of Wisconsin, Madison
Not yet recruiting

Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure

May 22, 2026

Conditions: Acute Heart Failure (AHF); Heart Failure; Congestion
Sponsors: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal; Carlos III Health Institute
Not yet recruiting

Periodontal Status in Patients With Oral Lichen Planus

May 22, 2026

Conditions: Oral Lichen Planus; Periodontitis
Sponsors: Catholic University of the Sacred Heart
Not yet recruiting

The CORE - μFR Clinical Trial

May 22, 2026

Conditions: Acute Coronary Syndromes (ACS); NSTEMI - Non-ST-Segment Elevation Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction; Multivessel Coronary Artery Disease
Interventions: Procedure: Angiography-guided PCI; Procedure: μFR based-PCI
Sponsors: University of Roma La Sapienza
Not yet recruiting

The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response

May 20, 2026

Conditions: Thyroid Cancer; Thyroid and Parathyroid Surgery; Hyperthyreosis and Goiter; Surgical Stress Response
Interventions: Other: bilateral ultrasound guided intermediate cervical plexus block with 0,25% levobupivacaine
Sponsors: University Hospital Dubrava
Active, not recruiting

Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)

May 20, 2026

Conditions: Critical Illness; Post Intensive Care Syndrome (PICS); Cardiopathy
Interventions: Other: Tele-rehabilitation; Other: Standard of Care
Sponsors: Fondazione Don Carlo Gnocchi Onlus
Recruiting

Exploratory Study on the Efficacy and Safety of Nebulized hUC-MSC-Derived Exosomes for Non-Acute CIP

May 20, 2026

Conditions: Pneumonitis, Interstitial; Immune Checkpoint Inhibitors (ICIs); Mesenchymal Stem Cells; Exosomes
Interventions: Drug: Nebulized hUCMSC-Exos; Drug: Nebulized normal saline
Sponsors: Zhou Chengzhi
Not yet recruiting

A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenous ABBV-1758 Moves Through the Body of Adult Participants With Alzheimer's Disease

May 20, 2026

Conditions: Alzheimer's Disease
Interventions: Drug: ABBV-1758; Drug: Placebo for ABBV-1758; Drug: ABBV-1758; Drug: Placebo for ABBV-1758
Sponsors: AbbVie
Not yet recruiting

Effects of Remimazolam on Neurocognitive Function in Patients Undergoing Cardiovascular Surgery

May 20, 2026

Conditions: Neurocognitive Disorder; Cardiac Surgery
Sponsors: Chinese Academy of Medical Sciences, Fuwai Hospital
Not yet recruiting

Effects of Multi-component Exercise on Physical Performance and Sleep Quality in Older Adults

May 20, 2026

Conditions: Aging; Sleep Quality; Physical Performance
Interventions: Behavioral: Multi-component Group Exercise Program
Sponsors: Tunghai University; Ministry of Education, Taiwan
Completed

Basic Body Awareness Therapy (BBAT) and Corrective Exercise for Adolescent Hyperkyphosis

May 20, 2026

Conditions: Hyperkyphosis, Adolescent
Interventions: Other: Corrective Exercise and Basic Body Awareness Therapy (BBAT); Other: Corrective Exercise and Autogenic Training
Sponsors: Istanbul University - Cerrahpasa
Not yet recruiting

Cardiovascular Risk in Peripheral Artery Disease Patients Undergoing Endovascular Revascularisation

May 20, 2026

Conditions: Peripheral Arterial Disease; Myocardial Injury; Troponin; NT-proBNP; Echocardiography; Endovascular Procedures; Biomarkers; Cardiovascular Diseases; Myocardial Ischemia
Sponsors: University Medical Centre Ljubljana
Active, not recruiting

Emulation of the EMPEROR-Preserved Trial Using Healthcare Claims Data

May 20, 2026

Conditions: Heart Failure With Preserved Ejection Fraction; Chronic Heart Failure; Type 2 Diabetes Mellitus
Interventions: Drug: Empagliflozin; Drug: Sitagliptin
Sponsors: Brigham and Women's Hospital; Food and Drug Administration (FDA)
Active, not recruiting

A Study of Complement 3 Glomerulopathy (C3G) Patients Treated With Iptacopan Through an Early Access Program in Spain

May 20, 2026

Conditions: Complement 3 Glomerulopathy
Sponsors: Novartis Pharmaceuticals
Not yet recruiting

Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA)

May 20, 2026

Conditions: Asthma (Diagnosis); Persistent Asthma; Moderate Asthma Exacerbation
Interventions: Drug: Anakinra 100 Mg/0.67 Ml Inj Syringe; Drug: Saline Placebo/0.67 Ml Inj Syringe
Sponsors: University of North Carolina, Chapel Hill; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Clinical Feasibility of Cardiac Neuromodulation Therapy for Heart Failure With Preserved Ejection Fraction

May 20, 2026

Conditions: Hypertension (HTN); Heart Failure With Preserved Ejection Fraction (HFpEF; Hypertension, Systolic
Interventions: Device: Moderato Plus device with Cardiac Neuromodulation Therapy
Sponsors: BackBeat Medical Inc
Not yet recruiting

Parasternal and Adductor Canal Blocks in CABG

May 20, 2026

Conditions: Postoperative Pain; Regional Anaesthsia; Pain Management
Interventions: Procedure: parasternal block; Procedure: Parasternal block + Adductor canal block; Other: conventional analgesic regimen
Sponsors: Zonguldak Bulent Ecevit University
Not yet recruiting

Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy

May 20, 2026

Conditions: Hypertrophic Cardiomyopathy (HCM)
Interventions: Drug: Aficamten
Sponsors: Oregon Health and Science University; Saint Lukes Hospital Mid America Heart Institute; Cytokinetics
Recruiting

FEMART-1 Pilot Study

May 20, 2026

Conditions: Sudden Cardiac Arrest; Out-of-hospital Cardiac Arrest (OHCA); Cardiogenic Shock Acute
Interventions: Procedure: Prehospital Ultrasound-Guided Femoral Arterial Sheath Placement
Sponsors: Emergency Medical Service, Prague; General University Hospital, Prague; Emergency Medical Service of the Central Bohemian Region, Czech Republic
Recruiting

Optimising Exercise to Improve Physical and Cognitive Frailty in Mild Cognitive Impairment

May 20, 2026

Conditions: Mild Cognitive Impairment (MCI)
Interventions: Other: Exercise training
Sponsors: Universiti Sains Malaysia; Singapore General Hospital; National Institute of Education, Singapore
Not yet recruiting

Reciprocal Mother-Infant Voice Exposure in the Neonatal Intensive Care Unit

May 20, 2026

Conditions: Maternal Attachment; Breastfeeding; Transient Tachypnea of the Newborn; Neonatal Intensive Care Unit
Interventions: Behavioral: Reciprocal Voice Exposure Group
Sponsors: Biruni University
Completed

Mobile Dual-Task Brain and Balance Intervention for Concussion Recovery

May 20, 2026

Conditions: Mild Traumatic Brain Injury (mTBI); Sports-related Concussion; Heart Rate Variability (HRV); Walking; Oculomotor; Saliva; Exosomal microRNA; Cognitive Function
Interventions: Behavioral: Home-Based Mobile Dual-Task Intervention (BraW-Day™)
Sponsors: Hyunhwa Lee; University of Nevada, Las Vegas
Not yet recruiting

The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients

May 19, 2026

Conditions: Senile Pruritus
Interventions: Drug: Esketamine; Drug: Normal Saline
Sponsors: Tianjin Medical University General Hospital
Not yet recruiting

Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF)

May 19, 2026

Conditions: Atrial Fibrillation (AF); Heart Failure; Catheter Ablation; Guideline Implementation
Interventions: Behavioral: LAP-Triggered Heart Failure Optimization Pathway
Sponsors: Medical College of Wisconsin
Active, not recruiting

Ginger in the Modulation of Inflammatory Cytokines and Oxidative Stress in Patients With Coronary Artery Disease

May 19, 2026

Conditions: Coronary Artery Disease (CAD); Oxidative Stress; Inflammation
Interventions: Dietary Supplement: Ginger; Dietary Supplement: Placebo
Sponsors: Universidade Federal Fluminense; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Rio de Janeiro State Research Supporting Foundation (FAPERJ)
Not yet recruiting

Cardiovascular Outcomes Registry in Cardiogenic SHOCK (COR-SHOCK)

May 19, 2026

Conditions: Cardiogenic Shock Acute; Cardiogenic Shock; Cardiogenic Shock Post Myocardial Infarction
Sponsors: Hospital de Santa Cruz, Portugal
Not yet recruiting

Food-Effect, Single and Multiple Dose Pharmacokinetics, Safety and Tolerability Study of 4-MUST, 128 mg, Tablets in Healthy Volunteers

May 19, 2026

Conditions: Chronic Cholecystitis; Biliary Dyskinesia
Interventions: Drug: 4-MUST
Sponsors: Valenta Pharm JSC
Recruiting

Effects of Accelerated rTMS on Sleep Architecture in Chronic Insomnia Disorder

May 19, 2026

Conditions: Insomnia; Chronic Insomnia; Chronic Insomnia Disorder; Sleep Disturbance
Interventions: Device: TMS
Sponsors: San Francisco Neurology and Sleep Center
Not yet recruiting

Olfactory Cell Transplantation and Intensive Rehabilitation to Repair Chronic Spinal Cord Injury

May 19, 2026

Conditions: Spinal Cord Injury; Neurological Conditions; Rehabilitation Exercise
Interventions: Biological: Olfactory Ensheathing Cell, biological intervention; Other: rehabilitation
Sponsors: Dr Brent McMonagle
Not yet recruiting

Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal

May 19, 2026

Conditions: Heart Failure; Renal Disease, Chronic
Interventions: Drug: Hypertonic sodium chloride 10%; Drug: Sodium Chloride 0.9%; Drug: Furosemide intravenous solution
Sponsors: University of Monastir
Not yet recruiting

Effects of AI-Generated Animated Videos on Dental Anxiety in Children

May 19, 2026

Conditions: Pediatric Dental Anxiety
Interventions: Behavioral: AI-Generated Animated Video Series; Behavioral: Tell-Show-Do (TSD) Technique
Sponsors: Alanya Alaaddin Keykubat University
Recruiting

Crossover vs Accurate Ostial PCI for Medina 0.0.1 and 0.1.0 Left Main Bifurcation Lesions

May 19, 2026

Conditions: Coronary Bifurcation Lesion; Coronary Artery Disease (CAD); Left Main Coronary Artery Stenosis
Sponsors: Istanbul Mehmet Akif Ersoy Educational and Training Hospital; Yalova training and research hospital; Mersin City Hospital; Van Training and Research Hospital; Başakşehir Çam & Sakura City Hospital; Bakirkoy Dr. Sadi Konuk Research and Training Hospital; Trakya University; Sisli Hamidiye Etfal Training and Research Hospital; Istanbul Training and Research Hospital; Medipol University; Samsun Education and Research Hospital; Kocaeli University; Abant Izzet Baysal University; Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital; Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; Bagcilar Training and Research Hospital; Ankara City Hospital Bilkent; Dicle University; Bursa Yuksek Ihtisas Training and Research Hospital; Haseki Training and Research Hospital; Ahi Evran University Education and Research Hospital; Ankara Etlik City Hospital; Izmir Bakircay University; Istanbul Medipol University Hospital; Kutahya City Hospital; Adiyaman University Research Hospital; Adana City Training and Research Hospital; Kosuyolu Heart Hospital; Ege University; Bursa City Hospital; Bilecik Seyh Edebali Universitesi; Siirt Training and Research Hospital; Hitit University
Active, not recruiting

Acute Effects of Caffeine on Repeated Sprint Performance and Energy Distribution

May 19, 2026

Conditions: Healthy Adult Male
Interventions: Other: Cycling Repeated Sprint Test (6 × 10 s); Other: Breath-by-Breath VO₂ Monitoring - COSMED K5; Other: Capillary Blood Lactate Sampling (non-invasive); Other: Heart Rate Monitoring
Sponsors: Trabzon University
Completed

A Clinical Study of Cizutamig in Thyroid Eye Disease

May 19, 2026

Conditions: Thyroid Eye Disease, TED
Interventions: Drug: Cizutamig will be dosed according to the protocol.
Sponsors: Candid Therapeutics
Recruiting

Respiratory and Exercise Responses by Body Roundness Index in Obesity

May 19, 2026

Conditions: Obesity
Interventions: Other: Observational
Sponsors: Biruni University
Not yet recruiting

Acute Kidney Injury : Long-term Renal and Cardiovascular Prognosis and Biomarker-based Risk Assessment

May 19, 2026

Conditions: Renal Injury, Acute
Sponsors: Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients

May 19, 2026

Conditions: Hypotension Drug-Induced; Spinal Aneshtesia; Geriatric; Orthopedic Surgery Patients
Interventions: Other: Lateral Decubitus Positioning; Other: Immediate Supine Positioning
Sponsors: University of Health Sciences Balikesir Hospital Eduation and Research
Not yet recruiting

Computer Interpretation of the ECG Raising Awareness CIERA Trial

May 19, 2026

Conditions: Proficiency in Computer Interpretation of the ECG
Interventions: Other: Flyer; Other: face-to-face lecture; Other: Online lecture
Sponsors: University of Jordan
Completed

Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Chronic Cholecystitis and Biliary Dyskinesia

May 19, 2026

Conditions: Chronic Cholecystitis; Biliary Dyskinesia
Interventions: Drug: 4-MUST; Drug: Placebo
Sponsors: Valenta Pharm JSC
Recruiting

Caffeinated Gum Use and Volleyball Performance

May 19, 2026

Conditions: Volleyball Players; Performance
Interventions: Dietary Supplement: Single-dose caffeinated gum; Dietary Supplement: Partial-dose caffeinated gum; Dietary Supplement: Placebo gum
Sponsors: Ege University
Completed

Low-Intensity Focused Ultrasound Targeting the Stellate Ganglion for Regulating Autonomic Nerve Function and Sleep Quality in Perioperative Patients With Cardiovascular Diseases

May 19, 2026

Conditions: Diagnosed With Cardiovascular Diseases and Scheduled to Undergo Interventional Cardiology Procedures
Interventions: Device: Low-intensity focused ultrasound (LIFU) targeting the left stellate ganglion; Device: Sham low-intensity focused ultrasound targeting the left stellate ganglion
Sponsors: Renmin Hospital of Wuhan University; Yichang Central People's Hospital; Wuhan Central Hospital; Huangshi Central Hospital; Wuhan Third Hospital; Xiangyang Central Hospital; Jingzhou Central Hospital
Not yet recruiting

Strengthening Children's Coordination and Balance in Everyday Life

May 19, 2026

Conditions: Physical Functional Performance; Physical Education and Training/Methods; Postural Balance; Child
Interventions: Other: Exercise; Other: Exercise
Sponsors: University of Applied Sciences for Health Professions Upper Austria; Barmherzige Brüder Linz
Active, not recruiting

A Registry to Assess the Efficacy and Safety of Transcatheter Treatment for Aortic Valve Disease at the IRCCS Policlinico San Matteo Foundation in Pavia (Italy).

May 19, 2026

Conditions: Severe Aortic Stenosis
Interventions: Device: Not applicable, as this is a registry tracking all TAVI procedures performed at IRCCS Policlinico San Matteo
Sponsors: Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting

Exercise Prescription in Children With Hypertrophic Cardiomyopathy

May 19, 2026

Conditions: Hypertrophic Cardiomyopathy Without Obstruction
Interventions: Behavioral: Exercise Prescription
Sponsors: Alder Hey Children's NHS Foundation Trust
Recruiting

Effect of Dexmedetomidine on Hemodynamic Stability in Carotid Endarterectomy: Reduced Norepinephrine Use and Propofol Dosing Via Central Sympatholytic Action

May 19, 2026

Conditions: Steno-occlusive Disease
Interventions: Drug: dexmedetomidine to the standard treatment; Other: Standard anaesthesia with propofol with co-administration of Dexmedetomidine and Propofol with Dexmedetomidine (bolus 0.4 mcg/kg over 10 minutes followed by an continuous infusion with 0.4 mcg/kg/h un
Sponsors: Insel Gruppe AG, University Hospital Bern
Not yet recruiting

Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation

May 19, 2026

Conditions: Chronic Obstructive Pulmonary Disease (COPD); Acute Coronary Syndrome; Fragility Fracture; Minor Stroke
Interventions: Behavioral: Digital Lifestyle Platform; Behavioral: Usual Care (Standard Post-Rehabilitation Care)
Sponsors: Matthias Wilhelm, MD
Recruiting

Effects of Royal Jelly and Propolis on Metabolomic Signatures, Inflammation, and Cardiovascular Risk in Patients With Coronary Artery Disease.

May 19, 2026

Conditions: Coronary Artery Disease (CAD); Oxidative Stress; Inflammation
Interventions: Dietary Supplement: Propolis + Royal Jelly; Dietary Supplement: Placebo
Sponsors: Universidade Federal Fluminense; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Rio de Janeiro State Research Supporting Foundation (FAPERJ)
Not yet recruiting