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ClinicalTrials.gov: Other terms: heart disease | First posted in the last 14 days

Studies found on ClinicalTrials.gov by a search of: Other terms: heart disease | First posted in the last 14 days

Extended Reality Cognitive and Breathing Training With Eye Tracking for Attention and Stress Regulation in Adolescent Basketball Players

October 09, 2026

Conditions: Healthy Adolescents
Interventions: Behavioral: Cognitive XR; Behavioral: Breathing XR
Sponsors: Riga Stradins University; European Union
Completed

Effects of Isometric Wall Squat Training on Blood Pressure in Adults With Hypertension

October 09, 2026

Conditions: Essential Hypertension
Interventions: Behavioral: Isometric Wall Squat (IWS) Exercise; Other: Standard Hypertension Care
Sponsors: Korea University Guro Hospital
Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults

October 09, 2026

Conditions: Friedreich Ataxia; Cardiomyopathies; Central Nervous System Diseases; Neuromuscular Diseases; Mitochondrial Diseases; Mitochondrial Dysfunction; Genetic Disease
Interventions: Drug: ATI-105; Drug: Placebo
Sponsors: Adjuvia Therapeutics, Inc.; Quotient Sciences
Not yet recruiting

Gastroesophageal Reflux and Respiratory Function in Patients Undergoing Abdominoplasty

October 09, 2026

Conditions: Abdominoplasty; Diaphragm; Respiratory Mechanics; Gastroesophageal Reflux Disease
Interventions: Other: Assessment of anthropometric and sociodemographic data and clinical history; Other: Assessment of Symptoms, Quality of Life, and Physical Activity; Other: Spirometric assessment; Other: Manovacuometry assessment; Other: Ultrasound Assessment of the Diaphragm, Abdominal Core, and Sternocleidomastoid; Other: Assessment of respiratory muscle endurance; Other: Thoracoabdominal kinematics; Other: Body bioimpedance assessment
Sponsors: Universidade Federal de Pernambuco
Not yet recruiting

Coronary Artery Calcium (CAC) Testing in Primary Care

October 09, 2026

Conditions: ASCVD; ASCVD Management; Coronary Artery Calcium; Hyperlipidemia
Interventions: Other: Our Practice Advisory (OPA)
Sponsors: Weill Medical College of Cornell University; Merck Sharp & Dohme LLC
Not yet recruiting

A Phase I Study to Investigate KH-001 in Healthy Males

October 09, 2026

Conditions: Healthy Male Volunteers
Interventions: Drug: KH-001 besylate; Drug: KH-001 besylate placebo
Sponsors: Kadence Bio
Completed

Study of ORJ-001 for the Treatment of IPF

October 09, 2026

Conditions: Idiopathic Pulmonary Fibrosis
Interventions: Drug: ORJ-001; Other: Placebo
Sponsors: Oorja Bio, Inc.
Recruiting

Self-administered Neurostimulation Intervention for Firefighter Traumatic Stress to Reduce Alcohol Use: Pilot Study

October 09, 2026

Conditions: Posttraumatic Stress Symptoms; Heavy Alcoholic Consumption; Alcohol Use Disorder (AUD)
Interventions: Device: Transcutaneous auricular neurostimulation (tAN); Device: Active Sham
Sponsors: University of Cincinnati; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Not yet recruiting

French Observatory on the Management of Cardiogenic Shock 2

October 09, 2026

Conditions: Cardiogenic Shock
Sponsors: French Cardiology Society
Not yet recruiting

The PICCOLETO XIII REVEAL-DCB Cohort A Study

October 09, 2026

Conditions: Coronary Artery Disease; Coronary Stenosis; Coronary Restenosis; Coronary Atherosclerosis; Vascular Remodeling
Sponsors: Fondazione Ricerca e Innovazione Cardiovascolare ETS
Not yet recruiting

Preterm Parturation Study

October 09, 2026

Conditions: Preterm Parturation; Preterm Premature Rupture of Membranes (PPROM)
Interventions: Other: Fetal ultrasound; Other: blood draw; Other: blood draw; Other: vaginal swab
Sponsors: Medical University of Graz
Not yet recruiting

Efficacy and Safety of the Angionix Balloon in Patients With Coronary Artery Disease Undergoing PTCA

October 09, 2026

Conditions: Coronary Artery Disease
Interventions: Device: Angionix Balloon
Sponsors: Yonsei University; NOBAMEDI CO., LTD.
Not yet recruiting

Post-exercise Blood Pressure With Inorganic Nitrate

October 09, 2026

Conditions: Obese Individuals; Central Adiposity
Interventions: Dietary Supplement: Beetroot Juice - Active + Exercise; Dietary Supplement: Beetroot juice placebo + Exercise; Dietary Supplement: Beetroot Juice - Active + No exercise; Dietary Supplement: Beetroot juice placebo+ No exercise
Sponsors: University of Virginia
Not yet recruiting

Exercise Snacks Enabled by an mHealth Intervention Delivered in General Practice to Promote a Sustainable Active Lifestyle in Adults With Obesity

October 09, 2026

Conditions: Obesity; Physical Inactivity; Sedentary Behavior
Interventions: Behavioral: Exercise snacks programme; Behavioral: Conversational agent; Device: Wrist-worn activity tracker; Behavioral: Standardised physical activity advice
Sponsors: Charles University, Czech Republic; University of Hradec Kralove; University of Ostrava
Not yet recruiting

First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy Volunteers

October 09, 2026

Conditions: Healthy
Interventions: Drug: [11C]JMJ-129-d2
Sponsors: National Institute of Mental Health (NIMH)
Recruiting

Effectiveness of Digital Cardiac Rehabilitation on Functional Capacity in Patients With Myocardial Infarction

October 09, 2026

Conditions: Myocardial Infarction; Tele-rehabilitation; FUCTIONAL MOBILITY
Interventions: Procedure: Conventional Treatment group; Procedure: Digital and Conventional treatment
Sponsors: Cairo University
Recruiting

ENDOBARIHEART STUDY

October 09, 2026

Conditions: Obesity & Overweight
Interventions: Other: echocardiography; Radiation: Coronary CT angiography; Biological: blood analysis
Sponsors: Maria Cecilia Hospital
Not yet recruiting

Biomarker Testing to Predict Radiation-Related Heart Disease in Lung Cancer Patients

October 09, 2026

Conditions: Non-Small Cell Lung Cancer; Radiation-Induced Cardiac Disease
Interventions: Diagnostic Test: Serum Pro-N-Cadherin Biomarker Assessment; Diagnostic Test: Echocardiogram
Sponsors: Duke University; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting

Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left Atrial Function Protection

October 08, 2026

Conditions: Paroxysmal Atrial Fibrillation; Pulsed Field Ablation; Catheter Ablation; Left Atrial Function; Cardiology
Interventions: Device: Novel Pulsed Field Ablation System; Device: Radiofrequency Ablation Catheter
Sponsors: Tianjin Medical University General Hospital
Not yet recruiting

UltraTrac Clinical Pilot Study

October 08, 2026

Conditions: Hemodynamic Monitoring
Interventions: Device: Noninvasive Hemodynamic Monitoring System
Sponsors: AcQumen Medical, Inc.; Children's National Research Institute
Not yet recruiting

eCPAP Follow-up at School Age

October 08, 2026

Conditions: Lung Function
Interventions: Other: Extended CPAP (eCPAP)
Sponsors: Cynthia McEvoy; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI); Indiana University
Not yet recruiting

Cardiac Biomarkers in Patients Receiving Immune Checkpoint Inhibitors (PRIME-ICI)

October 08, 2026

Conditions: Cardiotoxicity; Cardiac Biomarkers; Cancer
Sponsors: South Tees Hospitals NHS Foundation Trust
Not yet recruiting

The Effect of Respiratory Muscle Training on Respiratory Parameters

October 08, 2026

Conditions: Hypothyroidism Primary
Interventions: Other: Progressive Muscle Training; Other: Control Group
Sponsors: Cyprus International University; Eastern Mediterranean University
Completed

Finerenone's Impact on Cardiac Electrical Stability in HFpEF

October 08, 2026

Conditions: Heart Failure and Preserved Ejection Fraction; Atrial Fibrillation (AF); Arrythmia
Interventions: Drug: Finerenone; Drug: Placebo
Sponsors: Assiut University
Not yet recruiting

Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy

October 08, 2026

Conditions: Hypertrophic Cardiomyopathy
Interventions: Device: Coronary sinus reducer; Procedure: Placebo procedure
Sponsors: Imperial College London
Not yet recruiting

Trial of Innovative Fat-loss Focused Approaches in Patients With Class I Obesity: a Comparative Study

October 08, 2026

Conditions: Class I Obesity
Interventions: Drug: Tirzepatide; Device: Transcutaneous auricular vagus nerve stimulation
Sponsors: National Medical Research Center for Therapy and Preventive Medicine
Recruiting

Serum Endogenous Estrogens, Estrogen Receptors, and Sirtuin-1 and -3 After Resveratrol Supplementation

October 08, 2026

Conditions: Coronary Artery Disease (CAD); Menopause; Hormones
Interventions: Dietary Supplement: Trans-resveratrol, 1000 mg daily for 90 days; Other: Placebo
Sponsors: InCor Heart Institute
Recruiting

Common Femoral Vein-to-Artery Diameter Ratio for Detection of Elevated Left Ventricular End-Diastolic Pressure: Diagnostic Accuracy Study

October 08, 2026

Conditions: Diagnosis of Elevated LVEDP Using Ultrasound of the Common Femoral Vein to Common Femoral Artery Diameter Ratio
Interventions: Diagnostic Test: Ultrasound Measurement of Common Femoral Vein-to-Artery Diameter Ratio
Sponsors: Burapha University
Recruiting

Tissue Validation of Mammographic Breast Arterial Calcification in Mastectomy Specimens (SIDEMARA)

October 08, 2026

Conditions: Breast Cancer; Vascular Calcification; Coronary Artery Calcification; Atherosclerosis Cardiovascular Disease
Sponsors: Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Not yet recruiting

PrEcision Pacing in HFpEF: the PEP-HFpEF Trial

October 08, 2026

Conditions: Heart Failure and Preserved Ejection Fraction; Heart Failure New York Heart Association Class III; Heart Failure New York Heart Association (NYHA) Class II
Interventions: Device: Individualized myPACE pacemaker programming
Sponsors: Tufts Medical Center
Not yet recruiting

Low-Intensity Monitoring Nursing After Thrombolysis for Acute Ischemic Stroke

October 08, 2026

Conditions: Stroke, Ischemic
Interventions: Procedure: lower frequency of assessment of neurological impairment and vital signs; Procedure: standard frequency of assessment of neurological impairment and vital signs
Sponsors: Shengjing Hospital
Not yet recruiting

Immune Responses and Pulmonary Complications After Cardiac Surgery With Cardiopulmonary Bypass

October 08, 2026

Conditions: Cardiac Surgery Under Extra Corporeal Circulation
Interventions: Other: Blood sample collection; Other: Bronchoalveolar lavage fluid collection
Sponsors: Assistance Publique - Hôpitaux de Paris; Université Paris Cité; Institut National de la Santé Et de la Recherche Médicale, France; MASCOT, F-75006 Paris, France
Not yet recruiting

Echocardiographic Assessment of Valvular Dysfunction in Children With CHD

October 08, 2026

Conditions: Congenital Heart Disease; Valvular Heart Disease
Sponsors: Assiut University
Not yet recruiting

UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease

October 08, 2026

Conditions: Congenital Heart Disease; Cardiac Output; Hemodynamic Monitoring; Pediatric Heart Disease
Interventions: Device: UltraTrac
Sponsors: University of Minnesota
Not yet recruiting

Determination of Optimal Exercise Duration Using Intradialytic Exercises on Dialysis Adequacy, Fatigue, Depression, VO2 Max, Muscle Strength, Physical Functioning, and Quality of Life in Patients Undergoing Hemodialysis

October 08, 2026

Conditions: Hemodialysis
Interventions: Other: Combined Aerobic and Resistance Exercise; Other: Combined Aerobic and Resistance Exercise; Other: Combined Aerobic and Resistance Exercise
Sponsors: Ibadat International University, Islamabad
Not yet recruiting

Elevated Midline Positioning During Diaper Change in Preterm Infants

October 08, 2026

Conditions: Infant, Premature, Diseases; Premature Birth of Newborn; Pain
Interventions: Other: 30-Degree Elevated Midline Positioning; Other: Standard Lateral Position Diaper Change
Sponsors: Akdeniz University
Not yet recruiting

Understanding Spinal Cord Stimulation in Daily Life: Data Collection Via Smartwatch, Patient Questionnaires, and Stimulation Settings

October 08, 2026

Conditions: Persistent Pain Syndrome
Interventions: Device: Wearable-Based Continuous Physiological Monitoring with Implantable Pulse Generator (IPG) Data Correlation
Sponsors: Julia Mahler
Not yet recruiting

Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning

October 08, 2026

Conditions: STEMI; NSTEMI; Chronic Coranary Sindrome; Unstable Angina (UA)
Sponsors: A.O.U. Città della Salute e della Scienza; Ministero dell'Istruzione, dell'Università e della Ricerca
Completed

Suzetrigine in TKA

October 08, 2026

Conditions: Total Knee Arthroplasty (TKA); Total Knee Arthroplasty \(TKA\); Total Knee Replacement; Total Knee Replacement Surgery; Total Knee Replacements; Total Knee Replacement Arthroplasty; Suzetrigine; Pain Management; Pain; Nav 1.8; JOURNAVX; Opioid Cessation; Opioid Consumption, Postoperative; Multimodal Analgesia; Randomized Controlled Trial; Randomized Controlled Study; Randomized Controlled Trials
Interventions: Other: Placebo; Drug: Suzetrigine
Sponsors: Hospital for Special Surgery, New York
Recruiting

ThumpThump Pilot Study

October 08, 2026

Conditions: Preventive Medicine; Hypertension
Interventions: Other: : Implementation strategy to improve hypertension care in geopolitically defined communities
Sponsors: Yale University
Not yet recruiting

RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults

October 08, 2026

Conditions: Cyanotic Congenital Heart Disease; Right Ventricular Outflow Tract Obstruction
Sponsors: Assiut University
Not yet recruiting

Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy

October 08, 2026

Conditions: Postoperative Pain; Cholelithiasis
Interventions: Drug: Labetalol; Drug: Magnesium Sulfate; Drug: Lidocaine
Sponsors: Assiut University
Not yet recruiting

Clinical Trial for the Study of Stress and Exercise Impact on Glucose Levels and Additional Physiological Signals. Stress, Insulin and Exercise Study: a Trial in Argentina

October 08, 2026

Conditions: Type 1 Diabetes (T1D)
Interventions: Procedure: Structured Aerobic Exercise; Procedure: Structured Resistance Exercise; Procedure: Stress Test
Sponsors: National Council of Scientific and Technical Research, Argentina; Hospital Italiano de Buenos Aires; Instituto Tecnológico de Buenos Aires; Universidad Nacional de La Plata
Completed

Medical Management vs Partial Revascularization in Diffuse Multivessel Coronary Artery Disease

October 08, 2026

Conditions: Multi Vessel Coronary Artery Disease
Interventions: Procedure: Partial per cutaneous coronary intervention; Drug: Optimal medical therapy (OMT)
Sponsors: CH. Pervaiz Elahi Institute of Cardiology, Multan
Active, not recruiting

Comparison of Different Anesthetic Techniques on Hearing Outcomes in Neonates After Cesarean Delivery

October 08, 2026

Conditions: Pregnancy; Neonatal Hearing Function
Interventions: Procedure: Combined spinal-epidural anesthesia; Procedure: General Anesthesia (GA)
Sponsors: Second Affiliated Hospital of Wenzhou Medical University
Recruiting

Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy

October 08, 2026

Conditions: Tracheal Extubation; Cough
Interventions: Drug: remifentanil; Drug: Lidocaine %2 ampoule
Sponsors: Pamukkale University
Recruiting

Cardiovascular Risk Assessment and Coronary Calcium Score in Thai MASLD Patients

October 08, 2026

Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD); Cardiovascular Disease (CVD); Coronary Artery Calcification
Sponsors: Watcharasak Chotiyaputta
Recruiting

Stellate Ganglion Neuromodulation for the Treatment of Electrical Storm

October 08, 2026

Conditions: Ventricular Tachycardia (V-Tach) Storm
Interventions: Procedure: Stellate Ganglion Block Injection with Bupivicaine; Other: Sham procedure control
Sponsors: Population Health Research Institute; Hamilton Health Sciences Hospital
Not yet recruiting

Inspiratory Muscle Strength Training in Adults With Type 1 Diabetes

October 08, 2026

Conditions: Type 1 Diabetes
Interventions: Device: High-Resistance Inspiratory Muscle Strength Training; Device: Sham Inspiratory Muscle Strength Training
Sponsors: Florida State University; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Cardiovascular Risk Factors in Mexican Women

October 08, 2026

Conditions: Cardiovascular Risk Factors; Cardiovascular Diseases
Sponsors: Medicaweb, S.A.C.V.
Not yet recruiting

Effects of Hydrogen-rich Water Consumption on Transient Fatigue During an Official Football Match.

October 08, 2026

Conditions: Exercise-Induced Fatigue; Football Performance
Interventions: Dietary Supplement: Hydrogen-Rich Water (HRW); Dietary Supplement: Placebo Water
Sponsors: Palacky University; University of Split
Not yet recruiting

Functional Outcomes in Patients With Cerebral Infarction After Aquatic Physiotherapy and Aerobic Exercise

October 08, 2026

Conditions: Brain Ischemia
Interventions: Behavioral: Aquatic physiotherapy; Behavioral: Aerobic exercises
Sponsors: Lithuanian University of Health Sciences
Not yet recruiting

Study of GI001 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma and B-Cell Acute Lymphoblastic Leukemia

October 07, 2026

Conditions: B-Cell Non-Hodgkin Lymphoma; B-Cell Acute Lymphoblastic Leukemia
Interventions: Biological: GI001
Sponsors: Hematology department of the 920th hospital
Recruiting

High-Intensity Interval Training and Mental Health in Psychiatric Inpatients: A Pilot Study

October 07, 2026

Conditions: Anxiety; Depression; Mental Health; Psychiatric Inpatients
Interventions: Behavioral: High-Intensity Interval Training (1 × 4)
Sponsors: University Hospital of North Norway
Active, not recruiting

Evaluation of the UltraTrac System as a Non-Invasive Monitor of Hemodynamic Parameters

October 07, 2026

Conditions: Hemodynamic Monitoring
Interventions: Device: Noninvasive Hemodynamic Monitoring System
Sponsors: AcQumen Medical, Inc.
Not yet recruiting

Prevalence and Determinants of Therapeutic Non-Compliance in Patients With Chronic Pathologies ( PDTNCCP)

October 07, 2026

Conditions: Adherence, Medication
Sponsors: University of Monastir
Completed

Inspiratory Muscle Training in Hospitalized Patients With Heart Failure Awaiting Advanced Therapies: a Single-center Pilot Feasibility Study

October 07, 2026

Conditions: Heart Failure; Heart Failure New York Heart Association Class III; Heart Failure New York Heart Association Class IV
Interventions: Device: POWERbreathe KH2; Other: Usual Care
Sponsors: NYU Langone Health
Not yet recruiting

AI-based Decision Support in Acute Chest Pain

October 07, 2026

Conditions: Myocardial Infarction; Chest Pain
Interventions: Other: AIDE-CP available
Sponsors: Region Skane; Lund University
Not yet recruiting

Stopping Strep Throat With Antibodies in Healthy Adults.

October 07, 2026

Conditions: Streptococcal Pharyngitis
Interventions: Biological: Streptococcus pyogenes M1 challenge strain; Biological: Intravenous immunoglobulin (IVIG); Drug: Saline (NaCl 0,9 %) (placebo)
Sponsors: Murdoch Childrens Research Institute; University of Melbourne; University of Sheffield; Medical Research Council Unit, The Gambia; Walter and Eliza Hall Institute of Medical Research; London School of Hygiene and Tropical Medicine
Not yet recruiting

Efficacy of Electric Fans in Children During Heat Waves

October 07, 2026

Conditions: Heat Stress; Physiological Stress; Child Development
Interventions: Other: Simulated exposure to indoor overheating without fans; Other: Simulated exposure to indoor overheating with fans
Sponsors: University of Ottawa
Recruiting

Physiological and Molecular Adaptations to Different Training Modalities in National-level Kayak Athletes

October 07, 2026

Conditions: Exercise Training Adaptation
Interventions: Behavioral: High-Intensity Interval Training; Behavioral: Sprint Interval Training; Behavioral: Combined High-Intensity and Continuous Training; Behavioral: Control
Sponsors: National and Kapodistrian University of Athens
Completed

Impact of Dietary Flavanols on Microvascular Function in Young Females During Mental Stress

October 07, 2026

Conditions: Healthy
Interventions: Dietary Supplement: High-flavanol cocoa powder; Dietary Supplement: Low-flavanol cocoa powder
Sponsors: University of Birmingham
Completed

Non-invasive Hemodynamic Optimization of Sepsis in Internal Medicine: a Randomized Study Comparing Therapy Guided by Non-invasive Hemodynamic Indices Versus Standard of Care.

October 07, 2026

Conditions: Sepsis; Septic Shock
Interventions: Diagnostic Test: non-invasive hemodynamic assessment; Other: Treatment per SSC Guidelines
Sponsors: Regione del Veneto - AULSS n. 7 Pedemontana; University Hospital of Pisa
Recruiting

Extended Reality Rehabilitation in Parkinson's Disease

October 07, 2026

Conditions: Parkinson Disease
Interventions: Device: Extended reality balance training
Sponsors: University Hospital, Ghent; University Ghent
Not yet recruiting

Predicting Plaque Growth Using Blood Flow Stress Markers: A Proof-of-Concept Study

October 07, 2026

Conditions: Coronary Artery Disease (CAD)
Interventions: Procedure: PCCTA scan; Other: Endothelial cell isolation from peripheral blood sample
Sponsors: Queen Mary University of London; Barts & The London NHS Trust
Recruiting

Direct In-Scope Suction Versus Standard Flexible Ureterorenoscopy

October 07, 2026

Conditions: Renal Stone Disease
Interventions: Device: Standard flexible ureterorenoscope; Device: Flexible ureterorenoscope with direct in-scope suction
Sponsors: Hitit University
Recruiting

Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina

October 07, 2026

Conditions: Coronary Artery Disease (CAD); Stable Angina Pectoris; Ischaemic Heart Disease (IHD)
Interventions: Other: observational study
Sponsors: Queen Mary University of London
Recruiting

Controlled Ventilation During Anesthetic Emergence

October 07, 2026

Conditions: Emergence From Anesthesia; Mechanical Ventilation
Interventions: Device: Controlled/Full-Support Mechanical Ventilation During Emergence
Sponsors: King Abdulaziz Medical City; King Abdullah International Medical Research Center
Completed

AI-Based Conversational Social Support for Older Adults With Heart Failure

October 07, 2026

Conditions: Heart Failure; Social Frailty; Sarcopenia
Interventions: Behavioral: AI-Based Conversational Social Support; Behavioral: Community Social Participation
Sponsors: Chang Gung University of Science and Technology
Recruiting

Rhythmic Auditory Stimulation in Heart Failure Patients

October 07, 2026

Conditions: Heart Failure; Functional Capacity
Interventions: Behavioral: functional capacity; Behavioral: Fatigue and dyspnea
Sponsors: Necmettin Erbakan University
Active, not recruiting

Physical Activity and Functional Capacity in Patients With Congenital Long QT Syndrome

October 07, 2026

Conditions: Long QT Syndrome; Channelopathies
Interventions: Other: Questionnaires; Diagnostic Test: Cardiopulmonary exercise testing; Diagnostic Test: 24-hour Holter monitoring
Sponsors: University of Sao Paulo
Not yet recruiting

Effect of Omega 3 Fatty Acids on Heart and Liver in Beta Thalassemia Patients

October 07, 2026

Conditions: Thalassemia Majors (Beta-Thalassemia Major)
Interventions: Drug: Omega 3 Fish Oil supplements; Drug: Deferasirox
Sponsors: Ain Shams University
Completed

Testing the Effects of Temperature & Humidity on Children With and Without Asthma in an Environmental Climatic Chamber

October 07, 2026

Conditions: Asthma
Interventions: Other: Controlled Temperature and Humidity Exposure
Sponsors: University of Ontario Institute of Technology; The Hospital for Sick Children
Not yet recruiting

Cardiovascular Pre-participation Screening in Children and Adolescents

October 07, 2026

Conditions: Sudden Cardiac Death; Cardiac Arrhythmias
Interventions: Other: Pre-participation clinical evaluation; Diagnostic Test: Diagnostic Test: Resting 12-lead electrocardiogram; Diagnostic Test: Diagnostic Test: Step test (Harvard step test)
Sponsors: University of Sao Paulo
Not yet recruiting

Cardiovascular History and Hemodynamic Complications After Intubation in ICU

October 07, 2026

Conditions: Hemodynamic Complications
Sponsors: University Hospital, Strasbourg, France
Recruiting

BHF-COLLATE: UK Prospective, Multi-centre, Observational, Cardio-oncology Anthracycline Registry

October 07, 2026

Conditions: Cancer and / or Hematological Malignancy; Anthracycline-induced Cardiotoxicity
Sponsors: South Tees Hospitals NHS Foundation Trust
Not yet recruiting

Volution of Pulmonary Artery Dimensions in Tetralogy of Fallot

October 07, 2026

Conditions: Tetralogy of Fallot (TOF); Congenital Heart Defects
Sponsors: University Hospital, Strasbourg, France
Recruiting

Multicenter Prospective Cohort of Sepsis and ARDS in China

October 07, 2026

Conditions: Sepsis; ARDS
Interventions: Other: Surveys; Other: 6-Minute Walk Test; Other: Blood collection; Diagnostic Test: Pulmonary & Respiratory Muscle Function Testing; Radiation: CT Scan; Other: Blood Collection; Other: Bronchoalveolar Lavage Fluid; Other: HME filter samples
Sponsors: Shanghai Zhongshan Hospital
Recruiting

Testing the Investigational Medication Combination of Azacitidine, Venetoclax, and Quizartinib Compared to the Usual Treatment of Cytarabine, Daunorubicin, and Quizartinib for Patients With FLT3-ITD Mutant Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

October 07, 2026

Conditions: Acute Myeloid Leukemia
Interventions: Drug: Azacitidine; Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Drug: Cytarabine; Drug: Daunorubicin; Procedure: Echocardiography Test; Procedure: Multigated Acquisition Scan; Drug: Quizartinib; Drug: Venetoclax
Sponsors: National Cancer Institute (NCI)
Not yet recruiting

Cryoballoon Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation

October 07, 2026

Conditions: Paroxysmal Atrial Fibrillation (PAF)
Sponsors: Shenyang Northern Hospital; Tianjin Chest Hospital; The First Hospital of Jilin University
Not yet recruiting

Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)

October 07, 2026

Conditions: Traumatic Brain Injury
Sponsors: University of Michigan; Congressionally Directed Medical Research Programs
Not yet recruiting

Early Anticoagulation Therapy After Endovascular Treatment for Acute Ischemic Stroke With Atrial Fibrillation

October 07, 2026

Conditions: Stroke; Atrial Fibrillation (AF)
Interventions: Other: Early Initiation of DOAC Therapy; Other: Antiplatelet Bridging Followed by DOAC Therapy
Sponsors: Hao Yonggang
Not yet recruiting

Multi-center Research Clinical Trial Protocol for Etiology-pathology and Repair Classification of Mitral and Tricuspid Valves

October 07, 2026

Conditions: Heart Valvular Disease
Interventions: Procedure: Valve repair; Procedure: Valve replacement
Sponsors: Keli Huang
Not yet recruiting

Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years

October 07, 2026

Conditions: Hypotension (MeSH: D007022)
Sponsors: Karolinska Institutet
Not yet recruiting

Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance

October 07, 2026

Conditions: Venous Thromboembolism (VTE); Chronic Thromboembolic Pulmonary Hypertension; Right Ventricular Dysfunction; Pulmonary Embolism (PE)
Interventions: Other: Routine clinical care (no study intervention)
Sponsors: Azienda Ospedaliero-Universitaria Careggi; University of Florence; Azienda USL Toscana Centro; Azienda Ospedaliera di Perugia; Cardarelli Hospital, Naples, Italy; Azienda Ospedaliero, Universitaria Pisana; Azienda USL Toscana Nord Ovest; Medical University of Warsaw; Hospital Universitario Ramon y Cajal; A.O.U. Città della Salute e della Scienza - Molinette Hospital
Recruiting

Impact of Lung Cancer Screening With Chest Scans Combined With Coaching on Smoking Cessation in Heavy Smokers

October 07, 2026

Conditions: Lung Cancer (Diagnosis); Smoking Cessation; Lung Neoplasm
Interventions: Behavioral: Image-Based Counseling; Behavioral: Smoking Cessation Coaching; Radiation: Low-Dose Chest Computed Tomography (LDCT)
Sponsors: Hôpital Cantonal de Fribourg; CIPRET Fribourg (Centre d'information pour la prévention du tabagisme)
Not yet recruiting

CArdiovascular Phenotyping in Recreationally Active Saudi Women

October 06, 2026

Conditions: Healthy Active Females; Healthy Adult Female Participants
Sponsors: Imam Abdulrahman Bin Faisal University
Enrolling by invitation

Anorexia Nervosa, Evaluation and MOdification of Attention

October 06, 2026

Conditions: Anorexia Nervosa; Attentional Bias; Psychophysiology; Food; Interoception; Anxiety
Interventions: Other: Attentional Bias Modification Training
Sponsors: Lille University; Groupement des Hôpitaux de l'Institut Catholique de Lille
Not yet recruiting

The CLASP III TR CED Study

October 06, 2026

Conditions: Tricuspid Regurgitation; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases; Tricuspid Valve Insufficiency
Interventions: Device: PASCAL Precision system Treated; Other: Medicare Eligible Untreated Patients
Sponsors: Edwards Lifesciences
Not yet recruiting

Lifestyle, Dietary Patterns, and Cardiometabolic Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease Among People Living With HIV

October 06, 2026

Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD); HIV Infections; Non-Alcoholic Fatty Liver Disease; Liver Cirrhosis
Sponsors: Assiut University
Not yet recruiting

The Influence of the Thoracic Stiffness of CPR Teaching Manikins on the Accuracy of Compression in Cardiopulmonary Resuscitation

October 06, 2026

Conditions: Cardiac Arrest, Sudden; Cardiopulmonary Resuscitation (CPR); Manikins
Interventions: Other: different elasticity coefficients of the manikin device
Sponsors: Tang Ziren
Completed

Hyperoxemia and Oxygen Reserve Index During Neurointerventional Anesthesia

October 06, 2026

Conditions: Hyperoxia; Hyperoxemia; Cerebrovascular Disorders; Intracranial Aneurysms
Interventions: Other: Oxygen Reserve Index Monitoring (Observational)
Sponsors: Fatih Sultan Mehmet Training and Research Hospital
Not yet recruiting

Non-Invasive Assessment of Early Health Determinants in Children and Adolescents

October 06, 2026

Conditions: Cardiometabolic Health Indicators; Child Health
Sponsors: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Not yet recruiting

Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery

October 06, 2026

Conditions: Uterine Fibroids (Leiomyoma); Adenomyosis of Uterus; Endometriosis; Endometrial Cancer; Cervical Cancer; Ovarian Cancer
Interventions: Drug: DEX 0.2 μg/kg/h.; Procedure: SGB; Drug: 0.9% Sodium Chloride (Placebo); Procedure: Sham Stellate Ganglion Block
Sponsors: Catherin Zhang
Recruiting

A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity

October 06, 2026

Conditions: Cardiovascular Risk; Obesity
Interventions: Drug: Zenagamtide; Drug: Placebo
Sponsors: Novo Nordisk A/S
Not yet recruiting

On vs Off-hour PPCI in STEMI Patients

October 06, 2026

Conditions: Acute STEMI; PPCI; Observational Study; Coronary Artery Disease (CAD)
Sponsors: Assiut University
Not yet recruiting

Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders

October 06, 2026

Conditions: ICSI; IVF; Normal Responders; Infertility Assisted Reproductive Technology; Infertile Women Undergoing IVF or ICSI; Infertile Women Undergoing ART; Triggering Ovulation; Oocyte Maturation
Interventions: Drug: Dual trigger (human chorionic gonadotropin plus GnRH-agonist); Drug: hCG trigger
Sponsors: Al-Azhar University; International Islamic Center for Population Studies and Research
Recruiting

A Phase I Study of Allogeneic Myocardium-Derived Mesenchymal Stem Cells (HB1011) in Patients With Ischemic Cardiomyopathy

October 06, 2026

Conditions: Ischemic Cardiomyopathy
Interventions: Biological: HB1011 (Allogeneic Myocardium-derived Mesenchymal Stem Cells); Biological: HB1011 (Allogeneic Myocardium-derived Mesenchymal Stem Cells)
Sponsors: HieraBio Inc.
Recruiting

Virtual Reality During Coronary Angiography

October 06, 2026

Conditions: Coronary Angiography (CAG)
Interventions: Device: Virtual Reality Application
Sponsors: Karamanoğlu Mehmetbey University
Completed

Development of an Improved Method of Measuring Total Body Bone Perfusion Using Total-body PET/CT

October 06, 2026

Conditions: Healthy Volunteers - Male and Female
Interventions: Diagnostic Test: 1-hour Total Body PET/CT scan using the tracer [18F]-sodium fluoride
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust
Recruiting

Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight Gain

October 05, 2026

Conditions: Morbid Obesity
Interventions: Drug: Semaglutide weekly injection; Drug: Placebo
Sponsors: General Committee of Teaching Hospitals and Institutes, Egypt
Not yet recruiting

The Effect of White and Pink Noise in Patients Undergoing Total Hip and Knee Arthroplasty

October 05, 2026

Conditions: Arthroplasty, Replacement, Knee, Hip; Postoperative Nausea and Vomiting; Anxiety; Postoperative Pain After Arthroscopic Knee Surgery; Sleep Quality
Interventions: Behavioral: White Noise Intervention; Behavioral: Pink Noise Intervention
Sponsors: Ataturk University
Not yet recruiting

Effectiveness of Topical Chinese Medicine Ointment Therapy (TCMO) (Ng's Prescription) Eccentric Exercise for Tennis Elbow as Control: a Randomized Controlled Trial.

October 05, 2026

Conditions: Lateral Epicondylitis; TCMO (Ng's Prescription)
Interventions: Other: TCM ointment; Other: Control exercises
Sponsors: Hong Kong Baptist University
Not yet recruiting

Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of Immunosuppression

October 05, 2026

Conditions: Human Papillomavirus Infection; Anal HPV Infection; Human Papillomavirus 16 Infection
Interventions: Diagnostic Test: Anal Self-Sampling for High-Risk HPV Detection
Sponsors: University Hospital, Montpellier
Not yet recruiting

Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve Surgery

October 05, 2026

Conditions: Postoperative Delirium; Heart Valve Diseases
Sponsors: Osman Sila Aydin
Not yet recruiting

AI-Based Wearable Monitoring (Glandy HYPER) for Antithyroid Drug Dose Adjustment in Graves' Disease

October 05, 2026

Conditions: Hyperthyroidism; Graves Disease; Thyrotoxicosis
Interventions: Device: Glandy HYPER (AI-based monitoring software); Drug: Methimazole
Sponsors: THYROSCOPE INC.
Not yet recruiting

EXIT-CVD Project: Evidence Based Exit Strategies for the Cardiovascular Disease Continuum Trough Early Detection, Treatment and Evaluation

October 05, 2026

Conditions: CAD - Coronary Artery Disease
Interventions: Radiation: Photon Counting Computed Tomography (PCCT)
Sponsors: Centro Cardiologico Monzino
Active, not recruiting

Early Feasibility Study of the Edwards APTURE Transcatheter Shunt System

October 05, 2026

Conditions: Heart Failure
Interventions: Device: Edwards APTURE transcatheter shunt system
Sponsors: Edwards Lifesciences
Recruiting

Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers

October 05, 2026

Conditions: Head and Neck Carcinoma; Hypopharyngeal Carcinoma; Laryngeal Carcinoma; Oral Cavity Carcinoma; Oropharyngeal Carcinoma
Interventions: Other: Electronic Health Record Review; Drug: Fentanyl; Device: Laryngoscopy; Drug: Methadone; Procedure: Surgical Procedure; Other: Survey Administration
Sponsors: OHSU Knight Cancer Institute; Oregon Health and Science University
Recruiting

SI-B036-ST-101 in Advanced/Metastatic Solid Tumors

October 05, 2026

Conditions: Locally Advanced /Metastatic Solid Tumors; Locally Advanced / Metastatic Solid Tumors; Metastatic Solid Cancers; Non Small Cell Lung Cancer; Lung Cancer; Melanoma; Ovarian; NSCLC
Interventions: Drug: SI-B036
Sponsors: SystImmune Inc.
Not yet recruiting

Cardiovascular Safety of Atomoxetine in Children With ADHD

October 05, 2026

Conditions: Attention Deficit Hyperactivity Disorder
Sponsors: Assiut University
Not yet recruiting

Effects of Different Exercise Intensities on Lac-Phe Levels in Women With Obesity

October 05, 2026

Conditions: Obesity
Interventions: Behavioral: High-Intensity Interval Training; Behavioral: Moderate-Intensity Continuous Training
Sponsors: Istanbul Gelisim University
Completed

This Will be a Randomized Comparison of the Proteomic Effects of Vicadrostat/Empagliflozin Versus Empagliflozin and Versus Empagliflozin/Spironolactone in Heart Failure Patients With Preserved Ejection Fraction

October 05, 2026

Conditions: Heart Failure With Preserved Ejection Fraction (HFPEF)
Interventions: Drug: empa plus vica; Drug: Comparator: empa 10 plus spironolactone
Sponsors: Baim Institute for Clinical Research
Not yet recruiting

Immediate Versus Criterion-triggered Semaglutide for Suboptimal Clinical Response One Year After Primary Metabolic and Bariatric Surgery

October 05, 2026

Conditions: Morbid Obesity
Interventions: Drug: Semaglutide weekly injection; Drug: Placebo
Sponsors: General Committee of Teaching Hospitals and Institutes, Egypt
Not yet recruiting

Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access

October 05, 2026

Conditions: Obesity; Chronic Kidney Disease; Chronic Renal Disease; CKD
Interventions: Drug: Semaglutide; Behavioral: Virtual Weight Management Coaching
Sponsors: Kristin Clemens
Not yet recruiting

Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities

October 05, 2026

Conditions: Atrial Fibrillation; Sleep Apnea; Primary Aldosteronism
Interventions: Diagnostic Test: Screening on comorbidites
Sponsors: Christina Berr. MD
Recruiting

Video-Assisted Patient Education and Eye Fixation Training in Pterygium Surgery

October 05, 2026

Conditions: Pterygium; Preoperative Anxiety; Postoperative Pain
Interventions: Behavioral: Video-Assisted Patient Education
Sponsors: Ataturk University
Not yet recruiting

Semaglutide Before Primary Metabolic and Bariatric Surgery in Patients With BMI 60 kg/m² or Higher

October 05, 2026

Conditions: Morbid Obesity
Interventions: Drug: Semaglutide weekly injection; Drug: Placebo
Sponsors: General Committee of Teaching Hospitals and Institutes, Egypt
Not yet recruiting

AI-Based Differential Diagnosis and Localization of Tachycardia Using ECG: Multicenter Registry (EP-AI ASSIST)

October 05, 2026

Conditions: Tachycardia; Paroxysmal Supraventricular Tachycardia; Wolff-Parkinson-White Syndrome; Premature Ventricular Contractions; Ventricular Tachycardia
Interventions: Diagnostic Test: AI-based ECG Diagnostic and Localization Algorithm
Sponsors: Inha University Hospital
Recruiting

Engage-PD: a Physical Activity Coaching Program Via Telehealth for People With Parkinson's Disease. A Single-cohort Study in Spain.

October 05, 2026

Conditions: PARKINSON DISEASE (Disorder)
Interventions: Behavioral: Physical Activity Coaching
Sponsors: Hospital Clinic of Barcelona; Columbia University
Not yet recruiting

Indoor Overheating and Physiological Strain in Older Adults With COPD

October 05, 2026

Conditions: Chronic Obstructive Pulmonary Disease (COPD); Heat Stress
Interventions: Other: Simulated indoor thermal environment
Sponsors: University of Ottawa
Not yet recruiting

Evaluating the Therapeutic Potential of Focal Electrically Administered Seizure Therapy (FEAST) in the Treatment of Depression: A Multicenter Randomized Clinical Trial

October 05, 2026

Conditions: Major Depressive Episode (MDE); Unipolar Disorder; Bipolar 1 Disorder
Interventions: Device: Stimulation by the Sigma ECT/FEAST device; Device: Stimulation by Sigmastim ECT 200J device administered in right unilateral (RUL); Device: Stimulation by Sigmastim ECT 200J device administered in bilateral (BT)
Sponsors: Centre Hospitalier St Anne; Neuromodulation Institute
Not yet recruiting

Accelerated (Intensive) Cardiac Training for Heart Failure Patients

October 05, 2026

Conditions: Cardiac Rehabilitation; Heart Failure
Interventions: Other: Early Referral; Other: Standard Of Care (SOC) + Placebo
Sponsors: Washington University School of Medicine
Not yet recruiting

Subcutaneous Implantable Cardioverter-defibrillator (S-ICD) Eligibility Over Time in Arrhythmogenic Cardiomyopathy

October 05, 2026

Conditions: Arrhythmogenic Cardiomyopathy
Interventions: Diagnostic Test: Subcutaneous ICD ECG screening
Sponsors: University of Sao Paulo
Recruiting

Semaglutide 2.4 mg Once Weekly for Recurrent Weight Gain After Metabolic and Bariatric Surgery (RESURGE)

October 05, 2026

Conditions: Morbid Obesity
Interventions: Drug: Semaglutide weekly injection; Drug: Placabo
Sponsors: General Committee of Teaching Hospitals and Institutes, Egypt
Not yet recruiting

The CANadian EXAcerbation of COPD Trial

October 05, 2026

Conditions: COPD; AECOPD
Sponsors: McGill University Health Centre/Research Institute of the McGill University Health Centre; DiaSorin Inc.
Not yet recruiting

Tapered Versus Abrupt Discontinuation of Semaglutide After Treatment of Recurrent Weight Gain or Suboptimal Response Following Metabolic and Bariatric Surgery

October 05, 2026

Conditions: Morbid Obesity
Interventions: Drug: Semaglutide weekly injection; Drug: Placebo
Sponsors: General Committee of Teaching Hospitals and Institutes, Egypt
Not yet recruiting

Exercise Phenotyping Prior to Chemotherapy in Newly Diagnosed Multiple Myeloma (MM-Exercise)

October 05, 2026

Conditions: Exercise Behavior; Multiple Myeloma
Sponsors: Technical University of Munich
Recruiting

Nutritional Assessment in Children With Cardiomyopathy

October 05, 2026

Conditions: Cardiomyopathies; Malnutrition
Sponsors: Assiut University
Not yet recruiting

Molecular Autopsy in Young Individuals With Sudden Cardiac Death

October 05, 2026

Conditions: Tachycardia
Interventions: Genetic: Molecular autopsy by whole exome sequencing; Genetic: Cascade genetic screening by targeted Sanger sequencing
Sponsors: University of Sao Paulo
Recruiting

Optimal Anti-Thrombotic Management Following Percutaneous Left Atrial Appendage Occlusion

October 05, 2026

Conditions: Atrial Fibrillation (AF)
Interventions: Drug: Half-Dose of novel OAC; Drug: Low-dose ASA
Sponsors: Texas Cardiac Arrhythmia Research Foundation
Recruiting

Study to Assess the Efficacy and Safety of Rina-S Plus Standard of Care Compared to Standard of Care Maintenance Treatment After First-line (1L) Platinum-based Chemotherapy in Participants With Ovarian Cancer

October 05, 2026

Conditions: Ovarian Cancer
Interventions: Drug: Rina-S; Drug: Bevacizumab
Sponsors: Genmab
Not yet recruiting

Intra-ovarian CAPA-IVM vs Standard IVM

October 05, 2026

Conditions: Infertility (IVF Patients); Infertility; Infertility Female
Interventions: Procedure: CAPA-IVM; Device: In-House CAPA-IVM Pre-Maturation Medium; Procedure: Minimal-Stimulation OS-IVF
Sponsors: New Hope Fertility Center; Embryotools
Not yet recruiting

Trastuzumab/Pertuzumab With Fulvestrant and Kurmoxilil in HR+/HER2+ Early Breast Cancer

October 05, 2026

Conditions: Breast Cancer
Interventions: Drug: Trastuzumab (or biosimilar); Drug: Pertuzumab; Drug: Kurmoxilil; Drug: Fulvestrant
Sponsors: Hebei Medical University Fourth Hospital
Not yet recruiting

Transcutaneous Auricular Vagus Nerve Stimulation-Enriched Rehabilitation in Individuals With Lipedema

October 05, 2026

Conditions: Lipedema
Interventions: Device: Active taVNS; Device: Sham taVNS; Other: Aerobic Exercise; Other: Complex Decongestive Therapy (CDT)
Sponsors: Istanbul University - Cerrahpasa
Recruiting

Safety and Efficacy Comparison Between CHF5993 100/6 12.5µg pMDI to Seretide Evohaler 125/25µg pMDI in Adolescent Subjects With Asthma

October 05, 2026

Conditions: Asthma
Interventions: Drug: CHF5993 100/6/12.5 μg pMDI HFA-152a; Drug: Seretide Evohaler
Sponsors: Chiesi Farmaceutici S.p.A.
Not yet recruiting

Feasibility Study on the Implementation of a Program to Facilitate the Return Home of Patients With Heart Failure Following Hospitalization, Led by a Coordinated Multidisciplinary Team Based on the "Team-based Care" Model

October 05, 2026

Conditions: Heart Failure
Interventions: Other: Intervention Arm - TEAM-IC
Sponsors: Sant'Innovation; Direction Générale de l'Offre de Soin (DGOS); FeMaSCo-BFC; Agence Régionale de Santé - Bourgogne Franche Comté
Not yet recruiting

Uric Acid to Albumin Ratio for Predicting Contrast Associated Acute Kidney Injury After Cardiac and Non Cardiac Procedures

October 02, 2026

Conditions: Contrast-Induced Nephropathy; Acute Kidney Injury
Sponsors: Assiut University
Not yet recruiting

[11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction

October 02, 2026

Conditions: Heart Failure With Reduced Ejection Fraction; Cognitive Impairment, Mild; Neuroinflammation; Vascular Contributions to Cognitive Impairment and Dementia (VCID)
Interventions: Drug: [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand; Drug: Sacubitril-Valsartan
Sponsors: Stony Brook University; American Heart Association; National Institute on Aging (NIA)
Not yet recruiting

Pudendal Atherosclerosis by IVUS-NIRS in Men With Coronary Artery Disease

October 02, 2026

Conditions: Coronary Artery Disease; Erectile Dysfunction; Atherosclerosis
Interventions: Procedure: Selective Pudendal Angiography; Device: Pudendal IVUS-NIRS Imaging
Sponsors: Hospital Central Militar
Recruiting

A Clinical Study to Assess Safety, Efficacy and Pharmacodynamic Profile of GNT0004 in Duchenne Muscular Dystrophy

October 02, 2026

Conditions: Duchene Muscular Dystrophy
Interventions: Genetic: GNT0004 (1x10e13 vg/kg); Genetic: GNT0004 (3x10e13 vg/kg); Genetic: Placebo
Sponsors: Genethon
Recruiting

Digital Tai Chi Intervention on Physical Fitness, Anxiety, Depression and Stress Among College Students

October 02, 2026

Conditions: Health College Students
Interventions: Device: Virtual Reality-Assisted Tai Chi Training
Sponsors: Xin Liu
Active, not recruiting

Heart Failure Telemonitoring Across French Overseas Departments and Mainland France

October 02, 2026

Conditions: Heart Failure
Sponsors: Satelia; University Hospital Center of Martinique
Completed

A Multiphase Analysis of Next-generation Trail Footwear

October 02, 2026

Conditions: Running; Athletic Performance; Oxygen Consumption; Muscle Fatigue
Interventions: Other: Running footwear
Sponsors: Fernando González-Mohíno Mayoralas
Not yet recruiting

Effects of Physical and Cognitive Fatigue on Reaction Time and Depth Perception in Adolescents

October 02, 2026

Conditions: Fatigue; Reaction Time; Depth Perception
Interventions: Behavioral: Physical Fatigue Protocol; Behavioral: Cognitive Fatigue Protocol; Behavioral: Combined Fatigue Protocol; Other: Control Condition
Sponsors: AslanAhmetKaan
Completed

REFINE-CAC Protocol: Risk Evaluation With AI-CPA + HCS For Patients IN Whom Calcium is confirmEd to Improve Coronary Artery Disease Care

October 02, 2026

Conditions: CAD - Coronary Artery Disease
Interventions: Device: Heartflow Analysis
Sponsors: HeartFlow, Inc.; Avania
Not yet recruiting

Effect of Two Weeks of Low-Dose Apixaban on Platelet Reactivity in Patients With Stable Coronary Artery Disease on Dual Antiplatelet Therapy (Aspirin and Clopidogrel)

October 02, 2026

Conditions: Coronary Artery Disease; High On-treatment Platelet Reactivity (HTPR)
Interventions: Drug: Apixaban
Sponsors: The University of The West Indies
Active, not recruiting

Clinical Predictors and Therapeutic Gaps in CKM Syndrome Among Adults With Type 2 Diabetes

October 02, 2026

Conditions: Type 2 Diabetes Mellitus; Cardiovascular-Kidney-Metabolic Syndrome; Diabetic Kidney Disease
Interventions: Diagnostic Test: clinical and laboratory CKM staging evaluation
Sponsors: Assiut University
Not yet recruiting

The Effect of Telerehabilitation Exercises in Children With Congenital Heart Disease

October 02, 2026

Conditions: Congenital Heart Disease; Telerehabilitation; Functional Inspiratory Muscle Training
Interventions: Other: Inspiratory Muscle Training; Other: Functional Inspiratory Muscle Training
Sponsors: Izmir Democracy University
Not yet recruiting

ABVN Phase 2 - EDS Wearable Device

October 02, 2026

Conditions: Ehlers-Danlos Syndrome; Healthy Subjects
Interventions: Device: ML1101 Stimulus Isolator; Device: Cardiowatch Bracelet
Sponsors: Indiana University; Purdue University; National Institutes of Health (NIH)
Completed

Evaluate the Clinical Efficacy and Safety of Non-Compliant PTCA Balloon Dilatation Catheter

October 02, 2026

Conditions: Coronary Artery Stenosis; Coronary Artery Disease; Coronary Balloon
Interventions: Device: balloon angioplasty
Sponsors: TEDA International Cardiovascular Hospital
Completed

Trial Without Borders IMPLEMENT-CKD: IMPLEMENTation of Evidence-Based SGLT2i to Reduce Global Burden of Cardiovascular and Chronic Kidney Disease

October 02, 2026

Conditions: Implementation Research; Kidney Disease; Cardiovascular Disease; Chronic Illness
Interventions: Other: Implementation of recommendations
Sponsors: The University of Queensland
Not yet recruiting

Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run

October 02, 2026

Conditions: Exercise Physiology; Nutritional Supplementation
Interventions: Dietary Supplement: Caffeine; Dietary Supplement: L-Citrulline; Dietary Supplement: Exogenous Ketone (Beta-Hydroxybutyrate); Other: placebo beverage
Sponsors: St. Louis University
Recruiting

AI-Powered Electrocardiography for Diagnosis and Prognostic Prediction in Cardiovascular Disease (AI-CVD): Multicenter Retrospective Study

October 02, 2026

Conditions: Cardiovascular Diseases; Coronary Artery Disease; Heart Failure; Atrial Fibrillation (AF); Ventricular Hypertrophy
Interventions: Other: Retrospective ECG Data Analysis
Sponsors: Inha University Hospital
Recruiting

Reconsidering Long-Term Apirin in the Elderly in Secondary Prevention of Coronary Artery Disease Norway

October 02, 2026

Conditions: Coronary Arterial Disease (CAD)
Interventions: Drug: Discontinuation of aspirin (ATC-code B01AC06 and N02BA01)
Sponsors: Vestre Viken Hospital Trust; Oslo Universitetssykehus Hospital Trust; Akershus University Hospital Trust; Sorlandet Hospital HF; Helse Stavanger HF; Helse-Bergen HF; St. Olavs Hospital; Norwegian Health Association; Landsforeningen for hjerte og lungesyke (LHL); Bispebjerg Hospital; Odense University Hospital; University of Oslo; University Hospital of North Norway
Not yet recruiting

OPTIMized Diagnosis and Treatment System Based on AI and Multimodal Imaging Fusion for PCI (OPTIMAI-PCI)

October 02, 2026

Conditions: Coronary Artery Disease
Interventions: Device: AI-Based Imaging Fusion Guidance System; Procedure: Standard IVUS-Guided PCI
Sponsors: Zhejiang Hospital
Not yet recruiting

Starry-Sky Projection and Maternal Voice for Sleep After Pediatric Cardiac Surgery

October 02, 2026

Conditions: Congenital Heart Disease (CHD); Postoperative Sleep
Interventions: Behavioral: Starry-Sky Projection; Other: Conventional Lighting; Behavioral: Maternal Voice; Behavioral: Unfamiliar Female Voice
Sponsors: Shanghai Jiao Tong University School of Medicine
Not yet recruiting

Sacubitril/Valsartan Versus Valsartan Alone on Left Atrial Volume Index in Hypertensive Patients

October 02, 2026

Conditions: Hypertension; Left Ventricular Diastolic Dysfunction; Essential (Primary) Hypertension
Interventions: Other: Sacubitril / Valsartan; Other: Valsartan
Sponsors: University of Health Sciences Lahore
Not yet recruiting

Slow-Paced Breathing and Electrical Vagus Nerve Stimulation as Add-on Treatments for Depression

October 02, 2026

Conditions: Depression - Major Depressive Disorder
Interventions: Behavioral: Slow-Paced Breathing; Device: Transcutaneous Auricular Vagus Nerve Stimulation (tVNS); Device: Sham Auricular Electrical Stimulation; Other: Treatment as Usual (TAU)
Sponsors: Elisabeth Balint
Not yet recruiting

Comparison of Fractional FLOW Reserve Outcomes With Drug-Coated Balloon-Based Versus Drug-Eluting Stent-Only Percutaneous Coronary Intervention Strategies

October 01, 2026

Conditions: Coronary Artery Disease; Percutaneous Coronary Intervention; Drug Coated Balloon; Drug Eluting Stents (DES); Fractional Flow Reserve; Coronary Physiology
Interventions: Device: Drug-coated balloon-based intervention; Device: Drug-eluting stent-based intervention
Sponsors: Korea University Guro Hospital; B. Braun Melsungen AG
Not yet recruiting

Cooling During Inpatient Rehabilitation in Persons With MS

October 01, 2026

Conditions: Multiple Sclerosis; Heat Tolerance; Fatigue Symptom
Interventions: Other: Wearing a cooling vest during intensive, active training sessions; Other: Control
Sponsors: Klinik Valens
Recruiting

Impact of Stepwise Pressure-Increasing NC Balloon Post-Dilation on Stent Expansion

October 01, 2026

Conditions: Coronary Artery Disease; Drug Eluting Stents
Interventions: Device: Coronary stent + non-compliant post-dilation balloon
Sponsors: Jilin University
Recruiting

PAH-SDB: Sleep-Disordered Breathing and Outcomes in Pulmonary Arterial Hypertension

October 01, 2026

Conditions: Pulmonary Arterial Hypertension (PAH); Sleep-disordered Breathing (SDB)
Interventions: Diagnostic Test: Standardized Overnight Sleep and Cardiorespiratory Monitoring
Sponsors: Chinese Pulmonary Vascular Disease Research Group; Chinese Academy of Medical Sciences, Fuwai Hospital
Recruiting

Cardioprotection Effect of Linagliptin

October 01, 2026

Conditions: Cardiotoxicity
Interventions: Drug: Doxorubicin; Drug: Empaglifloz 5 mg orally once daily
Sponsors: Tanta University
Not yet recruiting

Evaluation of Safety, Side Effects, and How the Drug, Inhaled CHF10136, Is Absorbed, Modified and Removed From the Body in Healthy Adults and Adults With Asthma

October 01, 2026

Conditions: Asthma; Healthy Volunteers
Interventions: Drug: CHF10136; Drug: CHF10136 matched placebo
Sponsors: Chiesi Farmaceutici S.p.A.
Not yet recruiting

Brave Heart Intervention and Mental Health Outcomes Among Young People in Sierra Leone

October 01, 2026

Conditions: Substance-related Disorders; Mental Health Literacy; Adolescent Health; Substance Use Disorder (SUD)
Interventions: Behavioral: Brave Heart Intervention
Sponsors: Slum and Rural Health Initiative; Grand Challenges Canada
Completed

Postoperative Pacing for Cardiac Efficiency

October 01, 2026

Conditions: Pacing Therapy; Postoperative Care; Pediatric Congenital Heart Surgery; Cardiac Pacing; Postoperative Cardiac Surgery
Interventions: Other: Temporary Atrial Pacing
Sponsors: Robert G. Webster, MD, MPH; Ann & Robert H Lurie Children's Hospital of Chicago
Recruiting

Patient Selection and Long-Term Outcomes of Pace & Ablate Strategy in Atrial Fibrillation

October 01, 2026

Conditions: Atrial Fibrillation (AF); Cardiomyopathy, Secondary; Pacing-Induced Cardiomyopathy; Heart Failure
Sponsors: Insel Gruppe AG, University Hospital Bern; University of Bern; Liverpool Heart and Chest Hospital NHS Foundation Trust; University Hospital, Basel, Switzerland; University Hospital, Geneva; Silesian Centre for Heart Diseases, Zabrze
Recruiting

Dose-Response Effects of Short-Term Ashwagandha on Anaerobic Exercise and Cognitive Function in Resistance-Trained Athletes

October 01, 2026

Conditions: Resistance Exercise Performance; Cognitive Functions; Anaerobic Performance; Dietary Supplementation Athletic Performance
Interventions: Dietary Supplement: Low-dose Ashwagandha Supplement; Dietary Supplement: High-dose Ashwagandha Supplement; Dietary Supplement: Maltodextrin (Placebo)
Sponsors: Jacksonville State University
Completed

Music Intervention to Reduce Anxiety and Prevent Delirium in Older Adults Undergoing Cardiac Surgery

October 01, 2026

Conditions: Postoperative Delirium; Preoperative Anxiety; Cardiac Surgery
Interventions: Other: Music Intervention Group
Sponsors: KU Leuven
Not yet recruiting

Educational Intervention for Self-Care in Patients With Coronary Heart Disease and Type 2 Diabetes

October 01, 2026

Conditions: Coronary Heart Disease (CHD); Diabetes Mellitus, Type 2
Interventions: Behavioral: Experimental
Sponsors: Suleyman Demirel University
Completed

Aspirin 50mg vs 100mg Combined With P2Y12 Inhibitor After PCI

October 01, 2026

Conditions: Coronary Artery Disease; Acute Coronary Syndromes; Chronic Coronary Syndrome; Percutaneous Coronary Intervention
Interventions: Drug: Aspirin; Drug: P2Y12 inhibitor
Sponsors: Jilin University
Recruiting

Focused Ultrasound for Behavioral Health

October 01, 2026

Conditions: Depression; Anxiety; Obsessive Compulsive Disorder (OCD)
Interventions: Device: ATTN201 head-worn focused ultrasound
Sponsors: Attune Neurosciences Inc; University of California, San Francisco; University of Pennsylvania
Not yet recruiting

Preemptive and Postoperative Timing of Real-Time Sonar Guided Caudal Anesthesia for Pediatric Infra-Umbilical Procedures Analgesia

October 01, 2026

Conditions: Preemptive; Postoperative Timing; Real-Time; Sonar; Caudal Anesthesia; Pediatric Infra-Umbilical Procedures; Analgesia
Interventions: Drug: Caudal block immediately following induction of general anesthesia; Drug: Caudal block at the end of surgery
Sponsors: Benha University
Completed

Implementation of Mobile Intensive Care Unit Ultrasound Based Management for Acute Dyspnea

October 01, 2026

Conditions: Acute Dyspnea
Interventions: Diagnostic Test: Ultrasound pre-hospital care
Sponsors: Central Hospital, Nancy, France; Direction Générale de l'Offre de Soins
Not yet recruiting

Validation of an Algorithm for Predicting Awakenings Associated With Trauma-related Nightmares, Based on the Analysis of Physiological Patterns in Military and Former Military Patients Suffering From Post-traumatic Stress Disorder

October 01, 2026

Conditions: PTSD - Post Traumatic Stress Disorder; Trauma-related Nightmares
Interventions: Diagnostic Test: CAUD-PIN (CAUchemar Detection on INdividualized Parameters) - AI-based predictive algorithm forTrauma-related nightmare awakenings
Sponsors: Direction Centrale du Service de Santé des Armées
Recruiting

The Effect of Virtual Reality Application on Pain, Anxiety, and Embarrassment During Colonoscopy

October 01, 2026

Conditions: Colonoscopy
Interventions: Device: Virtual Reality (VR) Intervention Group
Sponsors: Kocaeli University
Enrolling by invitation

Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization

October 01, 2026

Conditions: Molar Incisor Hypomineralisation; Irreversible Pulpitis; Immature Molars
Interventions: Procedure: pulpotomy for MIH affected immature PFMs; Procedure: partial pulpotomy for MIH affected immature PFMs; Procedure: pulpotomy for non-MIH affected immature PFMs; Procedure: partial pulpotomy for non-MIH affected immature PFMs
Sponsors: Alaa Khafagy
Active, not recruiting

Pancreatin Added to Standard Antihyperglycemic Therapy in Patients With Type 2 Diabetes

October 01, 2026

Conditions: Type 2 Diabetes (T2DM)
Interventions: Drug: Pancreatin; Drug: Placebo
Sponsors: Silesian Centre for Heart Diseases; Medical University of Silesia
Recruiting

Right Heart and Lung Blood Flow During Exercise (RIGHT-NET 2.0)

October 01, 2026

Conditions: Right Ventricular Dysfunction; Cardiopulmonary Diseases; Pulmonary Hypertension
Sponsors: IRCCS SYNLAB SDN; University of Pisa; Institute of Clinical Physiology, CNR, Pisa; Fondazione IRCCS Policlinico San Matteo di Pavia; University of Milan; IRCCS Multimedica; University Of Perugia; ASST Grande Ospedale Metropolitano Niguarda; IRCCS Ospedale San Raffaele; University of Padova; Federico II University; University of Molise; University of Trieste; Medical University of Graz; Ohio State University; Jewish General Hospital (Montreal, Quebec, Canada); Universitat Politècnica de Catalunya; University Hospital Heidelberg; Institute of Family Medicine, University of Szeged, Hungary; Medical University of Lodz; Cardio-Thoracic-Vascular Department. University Hospital San Giovanni di Dio e Ruggi d'Aragona. Salerno; CRO "Centro Clinical Trials" IRCCS Ospedale Policlinico San Martino; Umberto I Hospital, Nocera Inferiore; Azienda Sanitaria Universitaria Friuli Centrale; Cardarelli Hospital; Azienda Ospedaliera dei Colli
Not yet recruiting

wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65

September 30, 2026

Conditions: Cardiovascular Diseases (CVD); Coronary Artery Disease; Atheroscleroses
Interventions: Behavioral: Arm 1: wCAR-CARE - Precision Prevention (Arm A); Behavioral: Guideline-directed standard of care
Sponsors: Women's Heart Austria
Not yet recruiting

ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease

September 30, 2026

Conditions: Obesity; Metabolic Dysfunction-associated Steatotic Liver Disease
Interventions: Combination Product: Survodutide; Combination Product: Placebo matching survodutide
Sponsors: Boehringer Ingelheim
Not yet recruiting

INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial

September 30, 2026

Conditions: Acute Respiratory Failure
Interventions: Other: Intubation with a sedative medication only; Other: Intubation with a sedative medication and neuromuscular blockade agent
Sponsors: Vanderbilt University Medical Center; National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

NutrImmune: Precision Nutrition to Improve Immunity in Individuals With Obesity

September 30, 2026

Conditions: Obesity (BMI>30); Immune Abnormalities; Low-grade Inflammation
Interventions: Other: Mixed test meal; Biological: Biological sampling; Behavioral: Questionnaires; Other: Caloric restriction; Other: Balanced-immunity diet
Sponsors: Institut National de la Santé Et de la Recherche Médicale, France; Amsterdam UMC, location VUmc; University of Hohenheim; University of Bern; Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute; Integrative Phenomics; Sorbonne University
Not yet recruiting

Walk Together Efficacy Trial

September 30, 2026

Conditions: Hypertension
Interventions: Behavioral: Walk Together; Behavioral: Hypertension education
Sponsors: University of Texas Southwestern Medical Center; National Institute on Minority Health and Health Disparities (NIMHD)
Not yet recruiting

High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)

September 30, 2026

Conditions: Myocardial Infarction (MI); Perioperative Myocardial Injury; Sepsis; Digestive System Surgical Procedures; Acute Kidney Injury; Postoperative Complication; Heart Injuries
Interventions: Diagnostic Test: High-sensitivity cardiac troponin T (hs-cTnT) surveillance
Sponsors: Bach Mai Hospital; Hanoi Medical University
Not yet recruiting

Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients

September 30, 2026

Conditions: Multiple Trauma; Polytrauma; Hemodynamic Instability; Traumatic Shock; Hemorrhage
Sponsors: Assiut University
Not yet recruiting

Deep Learning-Based Automated Pressure-Strain Loop Analysis

September 30, 2026

Conditions: Heart Failure
Interventions: Behavioral: Sustained Isometric Handgrip Exercise; Behavioral: Semi-Supine Bicycle Exercise
Sponsors: Norwegian University of Science and Technology; St. Olavs Hospital
Not yet recruiting

Point-of-Care Ultrasound for Diagnosing Abdominal Pain in the Emergency Department

September 30, 2026

Conditions: Emergency Medicine; POCUS; Abdominal Pain (AP); Acute Abdominal Pain; Ultrasound
Interventions: Diagnostic Test: Point of care ultrasound
Sponsors: University of Aarhus; Regionshospitalet Horsens
Not yet recruiting

Hemodynamic Effects of Trendelenburg Position and Pneumoperitoneum in Urologic Robotic Surgery

September 30, 2026

Conditions: Pneumoperitoneum, Artificial; Hemodynamics; Prostatic Neoplasms
Interventions: Procedure: Pneumoperitoneum and Trendelenburg Position
Sponsors: Ege University
Completed

COMPARISON OF THE TOPICAL ANAESTHETIC EFFICACY OF VARIOUS AGENTS WITH ANAESTHETIC EFFECTS IN CHILDREN

September 30, 2026

Conditions: Anxiety
Interventions: Other: Vemcaine; Other: Essences and Essential Oils; Other: VISION; Other: ICE; Other: Essences and Essential Oils
Sponsors: Uşak University
Completed

Autonomic and Renal Contributions to Hypertension With ADT

September 30, 2026

Conditions: Androgen Deprivation Therapy; Prostate Cancer; Hypertension; Autonomic Dysfunction; Renal Disease
Interventions: Drug: Gonadotropin Releasing Hormone Agonists (GNRH); Drug: Androgen receptor (AR) inhibitor; Drug: Placebo
Sponsors: Virginia Commonwealth University; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Assessment of the Preventive Effect of Defusing on Traumatic Kindling

September 30, 2026

Conditions: Acute Stress Disorder; Post Traumatic Stress Disorder PTSD
Interventions: Behavioral: Defusing; Behavioral: Psychological First Aid (PFA)
Sponsors: Hospices Civils de Lyon
Not yet recruiting

Clinical Evidence With Biomarker Confirmation for PPMI in PCI Clinical Trials Study

September 30, 2026

Conditions: Peri-procedural Myocardial Infarction; Heart Failure Hospitalization; Mortality; Stable Angina Pectoris; Non ST Elevation Myocardial Infarction (NSTEMI)
Interventions: Diagnostic Test: Biomarker testing
Sponsors: Baim Institute for Clinical Research
Not yet recruiting

Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma

September 30, 2026

Conditions: Childhood Posterior Fossa Ependymoma
Interventions: Procedure: Biospecimen Collection; Procedure: Echocardiography Test; Drug: Fluorouracil; Procedure: Lumbar Puncture; Procedure: Magnetic Resonance Imaging; Procedure: Multigated Acquisition Scan; Radiation: Radiation Therapy; Drug: Tretinoin
Sponsors: Children's Oncology Group
Not yet recruiting

Nurse-Led Self-Management and Breathing Intervention in Type 2 Diabetes

September 30, 2026

Conditions: Type 2 Diabetes Mellitus; Cardiovascular Autonomic Dysfunction
Interventions: Behavioral: Structured Nurse-Led Home-Based Self-Management and Paced-Breathing Program
Sponsors: Aziza Ibrahim Mohamed
Completed

Adaptation, Implementation, and Validation of an Innovative eHealth System for the Self-management, Monitoring, and Specialized Remote Medical Care of Patients With Diabetes in the Municipalities of Palermo (Huila) and Suárez (Cauca).

September 30, 2026

Conditions: Diabetes (DM)
Interventions: Device: Cloudi and Glucometer
Sponsors: Universidad Antonio Nariño; Ministry of Science, Technology, and Innovation, Minciencias; Hospital Universitario San Ignacio
Not yet recruiting

Minicrush Versus Culotte Stenting in Complex Coronary Bifurcation Lesions:The Multicenter T-REX II Registry

September 30, 2026

Conditions: Coronary Artery Disease (CAD); Percutaneous Coronary Intervention (PCI); Bifurcation Coronary Artery Disease
Interventions: Procedure: Percutaneous Coronary Intervention with Minicrush
Sponsors: San Luigi Gonzaga Hospital
Enrolling by invitation

Monitoring Blood Pressure at Home and Pharmacy Telehealth Among People Living With HIV

September 30, 2026

Conditions: Hypertension; Blood Pressure Monitoring
Interventions: Behavioral: Remote Blood Pressure Monitoring + Telehealth
Sponsors: University of Alabama at Birmingham; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

HypnoPain Relief for OA

September 30, 2026

Conditions: Osteoarthritis (OA)
Interventions: Behavioral: HypnoPain Relief (HPR); Other: Neutral Visual Exposure Waitlist Control
Sponsors: Gadjah Mada University
Active, not recruiting

Safety And Field Evaluation of Plasma Lyophilized for Acute and Surgical Management Applications

September 30, 2026

Conditions: Thromboembolic Event; FDP
Interventions: Biological: Freeze-Dried Plasma; Biological: Conventional Plasma
Sponsors: Teleflex; Westat; United States Army Medical Materiel Development Activity
Not yet recruiting

VITAL: Real-World Evaluation of Amlodipine/Valsartan.

September 29, 2026

Conditions: Hypertension; Cardiovascular Diseases (CVD)
Interventions: Drug: Amlodipine / Valsartan
Sponsors: VIVA PHARM LLP
Active, not recruiting

The Effect of Virtual Reality-Assisted Escape Room Experience

September 29, 2026

Conditions: Cardiac Arrest (CA)
Interventions: Behavioral: Virtual Reality-Supported Escape Room Training; Behavioral: Control Intervention
Sponsors: Ege University
Active, not recruiting

Progressive Heat Exposure and Physiological Strain

September 29, 2026

Conditions: Body Temperature Changes; Heat Stress; Heat Exposure; Heat Fatigue; Work Related Stress; Physiological Stress
Interventions: Other: Constant Heat Exposure; Other: Progressively Increasing Heat Exposure
Sponsors: University of Ottawa
Not yet recruiting

Intranasal Dexmedetomidine and Perioperative Myocardial Injury in Patients Having Percutaneous Coronary Interventions

September 29, 2026

Conditions: Coronary Heart Disease; Coronary Artery Disease
Interventions: Drug: Intranasal dexmedetomidine; Drug: Normal Saline
Sponsors: Second Affiliated Hospital, Zhejiang University, School of Medicine
Not yet recruiting

Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study

September 29, 2026

Conditions: Obstructive Coronary Artery Disease; Left Ventricular Hypertrophy
Sponsors: University of Pisa
Recruiting

Active Surveillance and Safety/Efficacy Evaluation of Innovative Devices for Structural Heart Disease Intervention

September 29, 2026

Conditions: Transcatheter Mitral Valve Edge-to-Edge Repair System; Biodegradable Patent Foramen Ovale Closure Device
Sponsors: Shanghai Jiao Tong University School of Medicine; Chinese Academy of Medical Sciences, Fuwai Hospital; Guangdong Provincial People's Hospital; LanZhou University; Shandong Provincial Hospital; Beijing Anzhen Hospital; Sichuan Provincial People's Hospital; Zhongnan Hospital; Shanghai East Hospital of Tongji University; ScienTech Medical; Valgen Medtech; The General Hospital of Northern Theater Command
Recruiting

Heart Failure in Women: Epidemiological and Prognostic Insights

September 29, 2026

Conditions: Heart Failure
Sponsors: Carolina Ortiz Cortes
Recruiting

Predicting Early Circulatory Deterioration After Short-Acting Beta-Blocker Treatment in Intensive Care Patients

September 29, 2026

Conditions: Critical Illness
Interventions: Drug: Esmolol; Drug: Landiolol
Sponsors: Shanghai Zhongshan Hospital
Completed

Aficamten and Patient-Reported Outcomes in Real-World nHCM

September 29, 2026

Conditions: Hypertrophic Cardiomyopathy (HCM)
Interventions: Drug: receiving aficamten
Sponsors: Second Affiliated Hospital, Zhejiang University, School of Medicine
Not yet recruiting

Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With Prediabetes

September 29, 2026

Conditions: Prediabetes
Interventions: Behavioral: Hourly 3-Minute Light Walking Breaks; Behavioral: Hourly Stair-Climbing Exercise Snacks
Sponsors: St. Louis University
Recruiting

A Study to Learn About the Study Medicine Called PF-08653944 in Otherwise Healthy Chinese Adults With Overweight or Obesity

September 29, 2026

Conditions: Overweight; Obesity; Healthy Adults
Interventions: Drug: PF-08653944
Sponsors: Pfizer
Not yet recruiting

Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications

September 29, 2026

Conditions: Type 2 Diabetes Mellitus; Cardiovascular Diseases; Coronary Artery Disease; Heart Failure; Arrhythmias; Arrhythmias Cardiac
Sponsors: Assiut University
Not yet recruiting

Evaluation of Mavacamten-Based Practice in Chinese Adults With Obstructive Hypertrophic Cardiomyopathy

September 29, 2026

Conditions: Obstructive Hypertrophic Cardiomyopathy (oHCM)
Interventions: Drug: Mavacamten
Sponsors: Bristol-Myers Squibb
Not yet recruiting

Comparison of Intraosseous Anesthesia and Inferior Alveolar Nerve Block for Primary Mandibular Molars

September 29, 2026

Conditions: Pain; Dental Caries
Interventions: Other: Inferior Alveolar Nerve Block; Other: intraosseous anaesthesia
Sponsors: Cumhuriyet University
Active, not recruiting

Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery

September 29, 2026

Conditions: Pain, Acute Post-Operative; Dexmedetomidine; Analgesia; Esmolol; Nociceptive Pain; Laparoscopic Hysterectomy
Interventions: Drug: Esmolol hydrochloride; Drug: Dexmedetomidine; Drug: Normal (0.9%) saline
Sponsors: Vasiliki Samartzi
Recruiting

Platelet Indices and Blood Groups in Type 2 Diabetes Vascular Complications

September 29, 2026

Conditions: Type 2 Diabetes Mellitus; Vascular Complications
Sponsors: Assiut University
Not yet recruiting

Safety and Feasibility of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening

September 29, 2026

Conditions: Induced Labor; Cervical Ripening; Cervical Ripening and Induction of Labor; Balloon Catheter for Labor Induction
Interventions: Device: Cervical ripening, labor Induction, uterus and fetal monitoring
Sponsors: Aalto University; West Tallinn Central Hospital
Not yet recruiting

A Prospective Study to Observe Clinical Outcomes in Patients Receiving Antiplatelet or Anticoagulant Therapy for Cancer-Associated Acute Ischemic Stroke

September 29, 2026

Conditions: Acute Ischemic Stroke; Cancer
Sponsors: Xuanwu Hospital, Beijing
Not yet recruiting

A Study of Dual Energy THERMOCOOL SMARTTOUCH™ SF Catheter With TRUPULSE™ Generator in Persistent Atrial Fibrillation

September 29, 2026

Conditions: Atrial Fibrillation
Interventions: Device: Radiofrequency/Pulsed Field Ablation
Sponsors: Biosense Webster, Inc.
Not yet recruiting

Percutaneous Stellate Ganglion Block as First Line Treatment in Patients With Electrical Storm: the STAR 2 Study

September 29, 2026

Conditions: Electrical Storm; VT; VF; Ventricular Arrhythmia; Ventricular Tachycardia (VT); Ventricular Fibrillation
Interventions: Drug: L-PSGB first
Sponsors: Fondazione IRCCS Policlinico San Matteo di Pavia; A.O.U. Città della Salute e della Scienza - Molinette Hospital; University Hospital Padova; Azienda Usl di Bologna; Azienda USL Toscana Centro; Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria; Azienda Sanitaria Locale N.1 dell'Umbria; Azienda Ospedaliera Brotzu; Azienda Ospedaliera di Perugia; Azienda Ospedaliera Niguarda Cà Granda; San Raffaele University Hospital, Italy; Centro Cardiologico Monzino; Ospedale San Donato
Not yet recruiting

Chatbot-based Pain Management for People With Knee Osteoarthritis

September 28, 2026

Conditions: Knee Osteoarthritis
Interventions: Behavioral: The C-MPPM intervention; Behavioral: Online education
Sponsors: The Hong Kong Polytechnic University
Enrolling by invitation

The Effect of Virtual Reality Headsets on Pain, Anxiety, Patient Satisfaction, and Physiological Parameters in Patients Undergoing Open-Heart Surgery

September 28, 2026

Conditions: Pain After Surgery; Pain and Anxiety; Anxiety After Surgery; Anxiety; Open Heart Surgery
Interventions: Behavioral: Virtual Reality Glasses
Sponsors: Dokuz Eylul University
Not yet recruiting

AI-Based Cardiac Analysis Using 12-Lead and 1-Lead ECG

September 28, 2026

Conditions: Heart Failure; Atrial Fibrillation (AF); Electrocardiogram
Interventions: Device: SmartECG-EF
Sponsors: Inha University Hospital
Not yet recruiting

A Legacy Study in Participants With Gastrointestinal Stromal Tumors (GIST)

September 28, 2026

Conditions: Gastrointestinal Neoplasms
Interventions: Drug: Velzatinib
Sponsors: GlaxoSmithKline
Not yet recruiting

Effect of Different-Flow High-Flow Nasal Cannula Versus Traditional Face Mask Oxygenation on Safe Apnea Time in Obese Patients

September 28, 2026

Conditions: Obesity
Interventions: Device: Face Mask; Device: High-Flow Nasal Cannula
Sponsors: The First People's Hospital of Lianyungang
Not yet recruiting

A Cluster-Randomized Controlled Trial

September 28, 2026

Conditions: Hypertension; Stroke; Cardiovascular; Coronary Heart Disease; Ischemic Heart Disease; Dyslipidaemia; Diabete Mellitus; Heart Failure; Cardiovascular Mortality; All Cause Mortality; Major Adverse Cardiac Event (MACE)
Interventions: Behavioral: AI-powered personalized health report with cardiologist consultation and prescription optimization; Behavioral: Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
Sponsors: Second Affiliated Hospital of Nanchang University
Not yet recruiting

Early Postoperative Triple Targeted Therapy in Patients With CHD-PAH in the "Grey Zone"

September 28, 2026

Conditions: Congenital Heart Disease, Pulmonary Hypertension
Interventions: Drug: Control group (ambrisentan plus tadalafil or macitentan plus tadalafil); Drug: Treatment group (ambrisentan plus tadalafil plus treprostinil or macitentan plus tadalafil plus treprostinil)
Sponsors: China National Center for Cardiovascular Diseases
Completed

Biomarkers as Prognostic Factors of Silent, Cerebral Infarctions in Patients Undergoing High-thromboembolic-risk Transcatheter Interventions

September 28, 2026

Conditions: Silent Cerebral Infarct; Biomarkers / Blood; Cardiac Ablation; Cognitive Impairment
Interventions: Procedure: High-thromboembolic-risk transcatheter interventions
Sponsors: Aristotle University Of Thessaloniki
Recruiting

Study of Eye Fatigue From Digital Screens and Its Impact on Visual Performance in People With Normal Vision and Myopia, With and Without Dry Eye Symptoms and Signs

September 28, 2026

Conditions: Myopia; Dry Eye Disease (DED)
Interventions: Device: Eye Exams; Device: Ocular Biometry and Aberrometry; Device: Wearing a Smartwatch; Device: Wearing Visual Correction; Device: Eye-Blinking Tests; Device: Retinal Examination; Device: Assessment of Signs and Symptoms of Dry Eye; Device: Assessment of Digital Eye Strain Symptoms; Device: Contrast Sensitivity Assessment; Device: Digital Eye Strain Task
Sponsors: Essilor International
Not yet recruiting

The Effect of Using a Stress Ball on Pain, Anxiety, and Vital Signs During Breast Biopsy

September 28, 2026

Conditions: Breast Biopsy; Procedural Pain; Anxiety; Vital Signs
Interventions: Behavioral: Using a Stress Ball
Sponsors: TC Erciyes University
Recruiting

AI-Based Personalized Self-Management for Patients With Heart Failure

September 25, 2026

Conditions: Heart Failure
Interventions: Device: Experimental: AI-Based Personalized Self-Management Intervention; Behavioral: Behavioral: AI-Based Personalized Self-Management Intervention
Sponsors: Alexandria University
Not yet recruiting

Supervised Exercise in Women With Breast Cancer

September 25, 2026

Conditions: Breast Cancer; Breast Neoplasms
Interventions: Behavioral: Supervised individualized exercise programme
Sponsors: University of Extremadura
Completed

Spinal Cord Stimulation for Blood Pressure Control in Hypertension

September 25, 2026

Conditions: Hypertension (HTN)
Interventions: Device: Lower Thoracic Spinal Cord Stimulation
Sponsors: University of Calgary
Not yet recruiting

Exercise and Tissue-Specific Insulin Sensitivity in South Asian and Nordic Women With Previous Gestational Diabetes

September 25, 2026

Conditions: Diabetes; Obesity & Overweight
Interventions: Behavioral: Exercise
Sponsors: Oslo University Hospital; University of Oslo
Completed

Myocardial Changes in Pediatric Guillain-Barré Syndrome

September 25, 2026

Conditions: Myocardial Dysfunction; Guillain-Barre Syndrome
Sponsors: Assiut University
Not yet recruiting

Betaine Addition to Water Loading Prior to Running Exercise

September 25, 2026

Conditions: Exercise; Hydration
Interventions: Dietary Supplement: Anhydrous Betaine; Other: Placebo
Sponsors: Poznan University of Life Sciences
Not yet recruiting

Exploring the Effect of the Hypershell Hip Exoskeleton on Fatiguing, Everyday Activities in Older Adults

September 25, 2026

Conditions: Fatigue; Older Adults (65 Years and Older); Exoskeleton Device
Interventions: Other: Performance test; Device: Hypershell assistance (EXO-ON Actuation)
Sponsors: Vrije Universiteit Brussel
Not yet recruiting

Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease

September 25, 2026

Conditions: Structural Heart Abnormality; Valve Heart Disease; Heart Diseases; Cardiovascular Diseases
Interventions: Device: EHR Alert
Sponsors: Pierre Elias; Edwards Lifesciences; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effects of Personalized Cardiac Rehabilitation on miRNAs and Biochemical Biomarkers in Patients With Coronary Artery Disease

September 25, 2026

Conditions: Cardiac Rehab; Coronary Artery Disease
Interventions: Behavioral: Personalized Cardiac Rehabilitation Program
Sponsors: Kutahya Health Sciences University
Not yet recruiting

The Effect of Digitally Enabled District (DED 2.0) Ecosystem on the Completeness and Timeliness of Maternal and Neonatal Services in Primary Health Care

September 25, 2026

Conditions: Digital Health; Maternal Health Services; Prenatal Care; Intensive Care, Neonatal; Postnatal Care
Interventions: Device: Digitally Enabled District (DED)
Sponsors: Summit Institute for Development, Indonesia; Bill and Melinda Gates Foundation
Not yet recruiting

Standardized Large Yellow Tea Extract for Glucose and Lipid Metabolism in Overweight Adults With Hypertriglyceridemia

September 25, 2026

Conditions: Hypertriglyceridemia; Overweight , Obesity
Interventions: Dietary Supplement: Standardized Large Yellow Tea Extract; Dietary Supplement: Placebo
Sponsors: The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial)
Not yet recruiting

PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery

September 25, 2026

Conditions: Postoperative Cognitive Dysfunction (POCD); Cardiac Surgery; Cardiopulmonary Bypass
Sponsors: Ain Shams University
Not yet recruiting

Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy

September 25, 2026

Conditions: Cerebral Palsy
Interventions: Behavioral: Humanoid Robot-Guided Active Play Intervention
Sponsors: University of British Columbia
Not yet recruiting

Real-World Effectiveness and Costs of Yiqi Fumai Lyophilized Injection in Coronary Heart Disease-Related Chronic Heart Failure

September 25, 2026

Conditions: Chronic Heart Failure; Coronary Heart Disease (CHD)
Interventions: Drug: Yiqi Fumai Lyophilized Injection
Sponsors: China Academy of Chinese Medical Sciences
Not yet recruiting

A Comparison of Left Bundle Branch Optimized Cardiac Resynchronization Therapy vs Left Bundle Branch Area Pacing Alone

September 25, 2026

Conditions: Heart Failure; Left Bundle Branch Area Pacing; Cardiac Resynchronization Therapy; Conduction System Pacing
Interventions: Device: LOT-CRT-P (Programming: LBBAP); Device: LOT-CRT-P (Programming: LOT-CRT-P)
Sponsors: PD Dr. Guram Imnadze
Not yet recruiting